Publication for PTTG1 and DEPDC1

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
hsa	PTTG1	PTTG1 regulator of sister chromatid separation, securin	9232			[link]
hsa	DEPDC1	DEP domain containing 1	55635

Pubmed ID	Priority	Text
29122991	0.97	pituitary tumor transforming gene 1 (PTTG1) and DEP domain containing 1a (DEPDC1A) overexpression has been reported in proliferative MM, and linked to poor prognosis.
29844366	0.96	DEPDC1, MCM2, CDK1, PTTG1, CDC20, PLK1, KPNA2 and AURKA) that are overexpressed in E2F high PDX and 13 mRNA (RHBDL2, DLEU7-AS1, TMEM63A, IGSF9, NEIL1, BDKRB2, PDZK1IP1, ERN2, CTSE, VSIG2, BCL2L15, LOC100505633 and TXNIP) that were, on the contrary, down-regulated in the same PDX were selected (for each transcript the raw p-values were < 0.002, FDR adjusted p-values < 0.05, t-test score > 6 and <=-6 and the fold change were >1.2 and <=-1.2)(see Supplementary Figure 4).
26445238	0.95	PTTG1 include DEPDC1 and the histone demethylase EZH2.
	0.95	Depdc1, which has previously been implicated in MM, was decreased by 38 % (p = 0.0055, t test) in the PTTG1-kd cells.
	0.92	DEPDC1 expression may be a mechanism whereby PTTG1 regulates cell proliferation in myeloma.
	0.91	DEPDC1 (Dishevelled, EGL-10, Pleckstrin domain containing 1) was significantly up-regulated in PTTG1 high patients.
	0.90	Pttg1 knockdown in myeloma cells leads to a 40 % reduction in DEPDC1 expression.
	0.81	Pttg1 in 5TGM1 cells decreased cellular proliferation, without affecting cell cycle distribution or viability, and decreased expression of Ccnb1, Birc5 and Depdc1 in vitro.
23704896	0.74	PTTG1, NUSAP1, DEPDC1, HELLS, CCNB1, KIF4A, and RRM2, that may be involved in tumorigenesis and in the processes of invasion and progression of disease.