Publication for NEK2 and PTTG1

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
hsa	NEK2	NIMA related kinase 2	4751			[link]
hsa	PTTG1	PTTG1 regulator of sister chromatid separation, securin	9232

Pubmed ID	Priority	Text
30719129	0.97	PTTG1, CDKN2A, NEK2, CENPF, CDCA5 and RACGAP1.
	0.89	PTTG1, CDKN2A, NEK2, CENPF, RACGAP1, GNA14 and especially the new gene CDCA5 may serve as biomarkers for diagnosis, treatment and prognosis of HCC.
	0.79	PTTG1 (P=0.00462), CDKN2A (P=0.00887), NEK2 (P=0.000828), CENPF (P=0.0304), CDCA5 (P=7.72E-05), RACGAP1 (P= 0.000754).
	0.69	PTTG1, CDKN2A, NEK2, CENPF, CDCA5 and RACGAP1.
26387737	0.96	Nek2A (for mitotic kinases), Securin, Sgo1 (for chromosome segregation), Survivin (for mitotic checkpoint), Geminin, Cdc6 (DNA replication), Skp2 (F-box for S phase), and Ets2 and FoxM1 (for transcription).
	0.90	Securin and Nek2A by Parkin and Cdc20/Cdh1.
	0.86	Nek2A, Cyclin B1, Securin, and Aurora A and B. Importantly, Parkin's interaction with Cdc20/Cdh1 is independent of APC/C. These studies identified a previously unknown ubiquitin ligase complex that plays an important role in mitosis.
31086582	0.95	NIMA related kinase 2 (NEK2), cell division cycle 20 (CDC20), aurora kinase A (AURKA), pituitary tumor-transforming 1 (PTTG1), cell division cycle 25A (CDC25A), SPC24 component of NDC80 kinetochore complex (SPC24), family with sequence similarity 83 member D (FAM83D), cyclin B2 (CCNB2), BUB1 mitotic checkpoint serine/threonine kinase (BUB1), centromere protein W (CENPW), cell division cycle associated 5 (CDCA5), cyclin A2 (CCNA2) and cell division cycle associated 3 (CDCA3) were significantly associated with cell division (P=2.29x10-13) and mitotic nuclear division (P=2.76x10-12; Table I).
	0.56	PTTG1, PRC1, NEK2, SPC24 and AURKA) were significantly involved in cell division (P=8.71x10-6).
25287299	0.94	Nek2A and cyclin A are degraded in prometaphase, immediately after nuclear envelope breakdown, whereas securin and cyclin B are degraded in metaphase.
24074588	0.93	NEK2A are degraded after nuclear envelope breakdown by the APC/CCDC20 complex and therefore evade control by the SAC; (b) Cyclin B and securin are the best-characterized APC/CCDC20 substrates that are degraded only after the SAC is satisfied by proper microtubule attachment to the kinetochores; (c) CDC20, PLK1, and Aurora B are ubiquitylated by the APC/CCDH1 complex after anaphase.
	0.89	NEK2A, cyclin B, securin, CDC20, PLK1, Aurora B and actin were assessed by Western blotting.
	0.74	NEK2A, cyclin B and securin normalized to actin for the experiment shown in panel A are plotted.
16987420	0.93	Nek2, Stathmin 1, Ckap2, Pttg1 (Securin), Cdc20, Mad2l1 (Table 1).
19286556	0.91	Nek2A) and metaphase substrates (cyclin B and securin).
21296579	0.90	NEK2A, and securin or Aurora kinases and cyclins, respectively.
	0.88	NEK2A), SAC proteins (e.g., MAD1, MAD2, securin, and separase), and motor proteins (e.g., dynein1, dynein activator complex dynactin, and KNSL1) (Figure 3).
21336306	0.90	Nek2A, but others are degraded only when the SAC is satisfied (metaphase) such as Cyclin B1 and securin.
32307883	0.83	securin ubiquitination, but only minimally affected Nek2A ubiquitination (Fig 3A).
	0.79	securin is repressed by the MCC, the kinase Nek2A is ubiquitinated.
	0.71	Nek2A or securin by the APC/CCdc20 and the effect of increasing concentrations of the MCC.
	0.57	Nek2A (B-E) or securin (F).
21082037	0.74	PTTG1 and ESPL1 as well as NEK2, BUB1, PLK1 and the progression genes CDC2 and CDC20.
20951947	0.62	Nek2A in addition to cyclin B1 and securin (Figure 5C).