Publication for CD3D and CD3E

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
hsa	CD3D	CD3d molecule	915			[link]
hsa	CD3E	CD3e molecule	916

Pubmed ID	Priority	Text
17822534	0.98	CD3delta, 62% CD3epsilon and 75% CD3zeta gene transcripts.
	0.96	CD3delta, then CD3epsilon and CD3zeta mRNA.
	0.96	CD3delta and CD3epsilon transcripts observed in infected cells, shown by flow cytometry to express ~95% TCR/CD3+ surface complexes (relative to the uninfected controls).
	0.95	CD3delta and CD3epsilon transcripts are completely lost while the CD3zeta transcripts are still expressed but at a very low level (data not shown).
	0.95	CD3delta, CD3epsilon, and CD3zeta gene transcripts leading to a CD3- surface phenotype after 200 days of in vitro infection; however, the sequence of gene loss has not been investigated.
	0.90	CD3delta, CD3epsilon and CD3zeta genes transcription, going on after early viral genes silencing.
	0.89	CD3delta and CD3epsilon genes are located in a 50 kb cluster on chromosome 11q23, with CD3gamma and CD3delta positioned head-to-head and separated by 1.6 kb.
	0.74	CD3epsilon potentially functions as an insulator by separating CD3gamma and CD3delta genes from a putative locus control region.
	0.66	CD3delta transcripts followed by a slower but also progressive reduction in CD3epsilon and CD3zeta transcripts.
15728236	0.98	CD3delta are overridden, but surface expression of the egamma and edelta dimers is prevented by the CD3e ER retention signal that remains functional.
	0.96	CD3e with either CD3gamma or CD3delta.
	0.92	CD3delta, CD3e, and CD3zeta) are each endowed with ER retention/retrieval signals, and regulation of its targeting to the plasma membrane is therefore especially intriguing.
	0.87	CD3delta may contain at least one cytoplasmic ER retention signal similar to those of CD3gamma and CD3e (triangle) and a di-leucine endocytosis signal (circle).
	0.72	CD3e first dimerizes with either CD3gamma or CD3delta, and the resulting egamma and edelta dimers associate with the TCRalpha and TCRbeta subunits.
22262845	0.97	CD3epsilon and TCRalphabeta, the majority of surface mutants of CD3delta and approximately half those of CD3gamma failed to reach the surface of Jluchi cells (supplemental Fig. S6, A and B).
	0.96	CD3delta and CD3gamma into the TCR complex was less efficient than for CD3epsilon, and only the most highly transfected cells could be analyzed.
	0.95	CD3delta and CD3gamma, CD3epsilon is apparently completely exposed in the complex.
	0.94	CD3delta with either of the CD3epsilon domains in the CD3epsilon homodimer, because the heterodimeric interfaces are distinct from the homodimeric interface (Fig. 2A).
	0.94	CD3epsilon would be precluded by prior heterodimerization of CD3epsilon with either CD3gamma or CD3delta (circled in Fig. 2A).
	0.93	CD3epsilon forms with CD3delta or CD3gamma (Fig. 5D; Refs. and).
	0.92	CD3epsilon as in C colored according to whether the residues are buried in the heterodimeric interfaces with CD3gamma (purple; as in Protein Data Bank code 1SY6), CD3delta (red; as in Protein Data Bank code 1XIW), or both (blue).
	0.92	CD3delta mutants that failed to reach the surface of Jluchi cells (Leu8 and Lys61) and one that reduced expression (Lys41) rescued CD3epsilon expression in 293T cells (supplemental Fig. S6, F and G), indicating that CD3delta folding, and presumably also CD3gamma folding, is extremely sensitive to mutation.
	0.90	CD3delta (blue) and CD3gamma (green) each docked with one of the CD3epsilon monomers in the CD3epsilon homodimer (red and yellow), in the manner observed in the NMR structures of the CD3epsilondelta and CD3epsilongamma heterodimers.
	0.86	CD3delta, formation of a CD3gamma-CD3delta-(CD3epsilon)2 heterotetramer via CD3epsilon homodimerization would nevertheless be precluded by steric clashes between the AB loops of CD3gamma and CD3delta and between the EF loop of each CD3epsilon monomer and the EF loop of the CD3gamma and CD3delta subunit bound to the other CD3epsilon monomer (Fig. 2B).
	0.86	CD3epsilon homodimer is shown in red and yellow, with CD3delta (blue; Protein Data Bank code 1XMW) and CD3gamma (green; Protein Data Bank code 1JBJ) shown docked with the red CD3epsilon monomer in the positions that CD3delta and CD3gamma occupy in the NMR structures of the CD3epsilondelta and CD3epsilongamma heterodimers.
	0.84	CD3epsilon with either CD3gamma or CD3delta creates a clash (circled) that prevents the formation of the small homodimerization interface involving the C-terminal loops of CD3epsilon (box (ii) in Fig. 1B).
	0.61	CD3delta, and CD3epsilon; (ii) TCRbeta, CD3gamma, and CD3epsilon; and (iii) TCRalpha and the two copies of CD3zeta.
	0.58	CD3delta and CD3gamma according to NACCESS (apart from those buried by CD3epsilon) were mutated and tested for expression in Jluchi cells.
22401598	0.97	CD3delta, CD3epsilon, CD3zeta and FcepsilonRIgamma in the PBMCs from 2 patients after treatment.
	0.96	CD3delta, CD3epsilon and CD3zeta genes decreased, and the FcepsilonRIgamma expression level of increased after treatment (Figure 2A, B).
	0.96	CD3delta and CD3epsilon expression levels were significantly increased in comparison with those in the healthy group.
	0.95	CD3delta expression level decreased from 3.95 to 0.63, the CD3epsilon expression level decreased from 19.14 to 2.23, the CD3zeta expression level decreased from 5.91 to 0.54, and the FcepsilonRIgamma expression level increased from 30.89 to 36.60 in the 4 months after treatment (Figure 2B).
	0.91	CD3delta, CD3epsilon, CD3zeta and FcepsilonRIgamma gene expression levels in 2 patients with AA who were in remission.
	0.83	CD3delta, CD3epsilon and CD3zeta returned to the normal range compared to the healthy group, whereas the CD3gamma and FcepsilonRIgamma expression levels did not.
	0.82	CD3delta, CD3epsilon and CD3zeta genes in patients with AA were significantly increased compared to a healthy control group, whereas the FcepsilonRIgamma gene expression level was significantly decreased in patients with AA in comparison with the healthy control group.
	0.76	CD3delta, CD3epsilon and CD3zeta) and the CD3zeta-related FcepsilonRIgamma gene in PBMCs from patients with AA.
	0.65	CD3delta, CD3epsilon, CD3zeta and FcepsilonRIgamma in PBMCs from the AA and healthy groups.
25946140	0.97	CD3E = CD3 Epsilon TCR complex; CD3D = CD3 Delta TCR complex; MMP8 = Matrix Metallopeptidase 8; IL7R = Interleukin 7 Receptor; OLFM4 = Olfactomedin 4; KLRC3 = Killer Cell Lectin-like Receptor subfamily C, member 3.
	0.97	CD3E, CD3G and CD3D.
	0.82	CD3E, CD3D, and KLRC2 (Striking Image) compared to baseline.
	0.57	CD3D, CD3E, and CD3G had decreased levels at week 1 post-transplant (Table 4), but levels increase towards pre-transplant levels at months 3 and 6 in the blood (Fig 1).
26388869	0.97	CD3epsilon, CD3gamma, and CD3delta subunit has been previously determined to be crucial for thymocyte development and T cell activation.
	0.90	CD3epsilon and CD3gamma can be classified to the C2-set, CD3delta adopts the C1-set fold.
20660709	0.97	CD3epsilon makes hydrophobic interactions with both the gamma-methyl of Thr62 and the hydrophobic beta-methylene position of the Gln64 side chain of human CD3delta.
22566957	0.96	CD3epsilon, CD3gamma, and CD3delta: A Potential Role in Structural Stabilization and Redox Sensitive Signaling Attenuation
	0.90	CD3epsilon is in light blue, CD3delta is in yellow, and CD3gamma is in green.
	0.85	CD3epsilon, CD3gamma, and CD3delta.
	0.84	CD3delta and CD3epsilon is highly conserved among species and of similar character as in CD3epsilongamma.
	0.50	CD3epsilon-CD3delta-TCRalpha-CD3zeta-CD3zeta as one cluster and CD3epsilon-CD3gamma-TCRbeta as a second cluster (Call et al.,), (ii) extracellular domain associations involving other in vitro chain association data (Manolios et al.,), TCR crosslinking results (Brenner,; Koning et al.,), and (iii) proximity of one CD3epsilon subunit to the TCR Cbeta FG loop revealed by quantitative T cell surface immunofluorescent antibody binding analysis (Ghendler et al.,).
20298603	0.96	CD3epsilon, CD3gamma or CD3delta.
	0.96	CD3delta, but not in zeta, CD3epsilon or TRIM, does not target for degradation.
	0.93	CD3epsilon always pairs with CD3gamma and CD3delta it can be concluded that the TRIM-containing alphabetaTCR has a stoichiometry of TCRalphabeta CD3epsilon2gammadeltazeta2TRIM2 (Figure 2C).
9236191	0.96	CD3-epsilon transiently expressed in COS cells could only be achieved with OKT3 when either CD3-gamma or CD3-delta were coexpressed.
24205042	0.96	CD3E, CD3D, and TXK.
9500786	0.95	CD3-delta both coimmunoprecipitate with anti-CD3-epsilon, and that degradation of CD3-delta in COS-7 cells is also inhibited by dMNJ.
	0.92	CD3-delta are particularly susceptible to degradation from the ER, whereas CD3-gamma and CD3-epsilon generally exhibit considerably longer half-lives.
	0.85	CD3-delta salvaged from degradation is largely bound to CD3-epsilon.
	0.74	CD3-delta or CD3-gamma allows heterodimers containing CD3-epsilon to be immunoprecipitated by 2C11, a monoclonal antibody that recognizes a conformation-dependent luminal epitope on CD3-epsilon.
20890284	0.95	CD3delta or CD3epsilon caused considerable defects in the assembly of TCRalpha-CD3delta-CD3epsilon, and the double-mutant CD3delta-CD3epsilon dimer had almost no detectable propensity to assemble with TCRalpha (Fig. 5e).
	0.94	CD3delta, CD3epsilon or CD3gamma; delta(TA) or epsilon(TA), mutant CD3delta or CD3epsilon with threonine-to-alanine substitution; gamma(SA), mutant CDgamma with serine-to-alanine substitution.
	0.77	CD3delta and CD3epsilon chains associated with the TCR (Fig. 5c).
	0.68	CD3delta-CD3epsilon-TCRalpha-TCRbeta-CD3gamma-CD3epsilon hexameric complex.
23226274	0.95	CD3delta, CD3epsilon, CD3gamma, TCRzeta could not express detectible levels of TCRbeta on the cell surface.
	0.94	CD3delta-Cub only, or CD3delta-Cub together with an unrelated prey protein did not grow, yeast cells expressing CD3delta-Cub and CD3epsilon-NubG grew and generated many colonies on selective plates.
28368009	0.95	CD3E, CD3D, and CD3G.
	0.88	CD3E, CD3D, and CD3G.
27183595	0.94	CD3delta than CD3gamma and closer to the CD3epsilon subunits than the CD3zetazeta subunits.
	0.86	CD3epsilon per TCR-CD3 complex, independent of the mEGFP tagged CD3 subunit, whereas mEGFP will be present according to the copy number of the tagged subunit: one for CD3delta and CD3gamma, or two for CD3epsilon and CD3zeta.
32138770	0.94	CD3D, p value = 0.0005 for CD3E; Additional file 1: Figure S3F).
	0.92	CD3E and CD3D in 21.12% B cell population, and CD79A, CD79B, and MS4A1 in 25.32% T cell population (Fig. 4).
21134635	0.94	CD3delta, CD3epsilon, and the zeta chain (CD247); collectively referred to as the TCR-CD3 complex.
32000799	0.93	CD3D, CD3E, MS4A1 and CTLA4, were exclusively overexpressed in the CD-MAT, showing relevant tissue-specific differences and suggesting that MAT in CD patients may constitute a memory immune response reservoir potentially implicated in the pathophysiology of the disease.
11342589	0.92	CD3epsilon and CD3delta chains, and resolved by SDS-PAGE under nonreducing conditions.
	0.85	CD3delta, and CD3epsilon chains were all associated with a pTalpha-containing complex of 100 kD immunoprecipitated from the surface of untransfected SUP-T1 pre-T cells, corresponding to the endogenous pre-TCR.
31921117	0.91	CD3delta or CD3epsilon chain expression has been shown to block the development of TCRalpha/beta T cells in both humans and mice, and human CD3zeta deficiency has been shown to reduce the number of circulating T cells, bearing a non-functional and restricted T-cell repertoire, and thereby causing severe combined T and B immune deficiency (SCID).
	0.86	CD3D, CD3E, and CD3Z gene defects cause severe combined T- and B-cell immunodeficiency.
20478055	0.90	CD3D, CD3E, CD3G or THY1 genes were found to be significantly associated with disease in this study.
	0.88	CD3-epsilon (CD3E), CD3-delta (CD3D) and CD3-gamma (CD3G), lie within 50 kb of each other in this region, forming part of the T-cell-receptor (TCR) complex.
	0.83	CD3E, CD3D, CD3G, IL10RA, THY1 and IL18.
	0.80	CD3E, CD3D, CD3G, IL10RA, THY1 and IL18, as risk factors for CD using a 2-phase candidate gene approach directed at chromosome 11q.
	0.59	CD3D, CD3E, CD3G, THY1 and IL18 were analysed for allelic, genotypic and carrier status association with disease individually and results are summarised in Table 2.
27832160	0.90	CD3D, CD3E, ZAP70, BCL11B, LCK, and RPL22.
	0.69	CD3 delta (CD3D) and epsilon (CD3E) are chains of the CD3 complex.
19013269	0.90	CD3delta (light green), and CD3epsilon (orange).
17923503	0.89	CD3epsilon pairs with either CD3gamma or CD3delta.
23046125	0.88	CD3epsilon nor the strand D in CD3delta is a regular beta strand.
	0.84	CD3epsilon, CD3gamma and CD3delta) each comprise a single extracellular Ig-like domain followed by a short stalk region, referred to as a connecting peptide (CP), a transmembrane (TM) helix, and a cytoplasmic tail.
31064990	0.88	CD3epsilon with CD3gamma, one dimer of CD3epsilon with CD3delta, and one CD3zeta homodimer.
	0.75	CD3delta, or CD3epsilon TCR subunits via a flexible glycine serine linker.
23932713	0.88	CD3epsilon is stable by itself, it could not retain the alpha-chain in the membrane or stabilize it against degradation as efficiently as CD3delta and epsilon together (Figures 5D-G and S5C-F).
29967623	0.86	CD3D, CD3E, and CD3G, which were consistent with the KEGG results.
	0.66	CD3D/NFATC2/CD3E/LCK/CD3G panel, and FASLG/CD8A/PRF1/granzyme B panel.
	0.66	CD3D, CD3E, and CD3G) were involved in hematopoietic cell linage pathway (Figure 4A).
	0.66	CD3D, LCK, CD3E, NFAT, ZAP70, GADS, FYN, ITK, P38, and IFNgamma) were mapped to T cell receptor signaling KEGG pathway (Figure 6A).
31817155	0.86	CD3E, and CD247 (CD3Z) were all more expressed in DS samples, whereas CD4, CD3D, and CD3G were not differentially expressed between DS and NDS.
	0.73	CD3D and CD3E, which are part of the T-cell receptor/CD3 complex, that couples antigen recognition to several intracellular signal-transduction pathways; CD7, found on thymocytes and mature T cells and playing an essential role in T cell interactions; CD40LGT, expressed on the surface of T cells, regulating B cell function by engaging CD40 on the B cell surface; CD74 that associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response; CD79B, the B lymphocyte antigen receptor, a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig), necessary for expression and function of the B-cell antigen receptor; CD83, involved in the regulation of antigen presentation; CD96 that plays a role in the adhesive interactions of activated T and NK cells during the late phase of the immune response, as well as function in antigen presentation.
9547330	0.86	CD3-delta, CD3-epsilon, CD3-zeta) are responsible for signal transduction.
29977931	0.84	CD3E, CD3D, IFNG, VAV1, TNF, B2M, CXCR3, CCR5, CCL5, CXCL9, CXCL10, CXCR4, GNG2, IL1B, IL12B, IL2RB, IL2RA, IL2RG, STAT1, CD8A, CD86, PTPRC, PIK2CG, CD44, and HLA-DPA1 and 1 downregulated protein EGF.
	0.69	CD3D, CD3E, and CD3G, which are compositions of CD3 complex of TCR, interacted with each other to affect the assembly of TCR membrane complex and disturb T-cell responsiveness, especially CD3E.
	0.64	CD3D, TNF, VAV1, and CD3E in previous studies.
26997265	0.83	CD3delta and CD3epsilon are depicted light blue, dark blue and red respectively.
23885256	0.80	CD3delta contact the TCR, whereas CD3epsilon projects away from the receptor.
32020855	0.76	CD3E, CD3G, CD3D, CD79B, CD79A.
22500808	0.74	Cd3d, Cd3e, Cd3z (Cd247), T-cell-specific signaling components Itk and Lat, recombinase Rag1, mutagenic DNA polymerase Dntt, and the surrogate alpha chain (pTalpha) Ptcra.
	0.59	Cd3e and Cd3d were already marked by focal H3K4me2.
18320063	0.73	CD3delta,CD3epsilon and CD3zeta [CD247]).
	0.57	CD3epsilon forms non-covalently-bound alternate dimers with CD3gamma and CD3delta, TCRalpha forms disulfide-linked dimers with TCRbeta, and CD3zeta is expressed in the form of disulfide-linked homodimers.
24244363	0.73	Cd3-delta, CD3-epsilon and CD3-zeta.
25848820	0.73	CD3D, CD3E, CD3G, CD247 (CD3zeta), CD8A, CD27, CD52, CD96, PYHIN1, SLAMF6, and IL12RB1).
9120393	0.65	CD3-delta, and CD3-epsilon, pTalpha, and RAG-1 transcripts, and has partially rearranged the TCR-beta locus strongly suggested that committed T cell precursors were present.
29976994	0.63	CD3delta, CD3epsilon and CD3zeta) without intrinsic enzymatic activity, but functionally associated to cytoplasmic tyrosine kinases.
21078154	0.62	CD3delta, CD3epsilon, CD3zeta), protein-tyrosine kinases (e.g., Fyn, Lck, ZAP-70), protein-phosphotyrosine phosphatases (CD45, and others), etc.
23096155	0.62	CD3e, CD3delta, CD247), LAT, TCR signaling molecules (protein kinase c theta (PRKCQ), protein tyrosine phosphatase receptor type C (PTPRC), C-SRC tyrosine kinase (CSK), SYK, lymphocyte-specific protein tyrosine kinase (LCK)), integrins CD2, CD44, integrin alpha L, M and X (ITGAL, ITGAM, ITGAX) and cyclin D3 (CCND3) (Supplementary Figure S2B, Table 1 and Supplementary Table S5).