Publication for PRC1 and MELK

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
hsa	PRC1	protein regulator of cytokinesis 1	9055			[link]
hsa	MELK	maternal embryonic leucine zipper kinase	9833

Pubmed ID	Priority	Text
31068579	0.98	MELK, PRC1, and RACGAP1, are analyzed by real-time PCR.
	0.96	melk, racgap1, prc1, and hmgb1) related to cell cycle, we checked their expression patterns, and found their expression kinetics were similar to CD168/HMMR+ MSCs, enriched on the top right of the plot (Fig. 4b).
	0.96	melk, prc1, and racgap1.
	0.95	melk, hmmr, racgap1, prc1, and hmgb1.
	0.94	melk, prc1, and racgap1.
30158955	0.97	MELK, (H) NDC80, (I) PRC1, (J) RACGAP1, (K) SPAG5, (L) TPX2.
	0.73	MELK, NDC80, PRC1, RACGAP1, SPAG5, and TPX2) (Figure 4D).
31566930	0.96	MELK, PRC1, STIL, and TPX2 have been identified as candidate genes.
	0.87	PRC1, MELK, STIL, and TPX2.
29699511	0.96	PRC1, MELK, KPNA2, CDC20, CDC2 and UBE2S, overlapped in signatures developed for ER-positive and mixed breast cancer subtypes.
31883309	0.96	PRC1, MELK, KIF15 and FOXM1) were generated by taking the intersection of them (Figure 2C).
31949481	0.96	PRC1, SPAG5, AURKA, TPX2, BUB1, MELK and CCNA2 were up regulated in PLAU+FOXM1+ subgroup in comparison with PLAU-FOXM1- subgroup, which participate in diverse aspect of physiological and pathological process, such as NF-kB pathway, cytoskeletal signaling, adheren junctions remodeling, chromosome remodeling, cell cycle, calcium channel, DNA repair and TGF-beta signaling pathways.
28190297	0.95	PRC1 depletion down-regulated the mitotic-related genes including KIF4A, BUB1B, AURKB, NEK2, NUSAP1, MELK and TOP2A in AGS instead of HGC27 cells.
26000042	0.94	MELK, MCM4_1, CCNB1, CENPE, CEP55, RRM2_2, CDC20, NME1, MCM4_2, NCAPG_2, MLF1IP, CDC2_2, PTTG3, BUB1, CDCA8; EGFR_1 upstream SLC2A1, CCNB2, HMMR, KIF11, NUSAP1_1, PRC1, FANCI_1, HIST1H2BD_2, TPX2, MYBL2, UBE2C, PAICS_2, NUDT1; EGFR_1 downstream BIRC5_1, RRM2_1, KIF20A, KIAA0101, MKI67_1, AURKA_1, KIF4A, SFXN1, AURKA_2, KDELR2_1, PPP1R14B, ZWINT, CDC25C, DSP, ASF1B, MCM2, CENPM, ALDOA, KDELR2_2, as shown in Supplementary Figure 2.
	0.67	MELK, MCM2, MLF1IP, NME1, NCAPG_2, NUSAP1_1, PTTG3, PPP1R14B, PRC1, RRM2_1, RRM2_2, TOP2A_1, MKI67_1, ASF1B, AURKA_1, AURKA_2, BUB1, CENPE, FANCI_1, HIST1H2BD_2, KIAA0101, MCM4_1, MCM4_2, CDC2_2, TPX2, MYBL2, ZWINT, UBE2C, KIF20A, CDC20, PAICS_2, CEP55, NUDT1, as shown in Supplementary Figure 1A.
19851466	0.94	MELK, NDC80, NUSAP1, ORC6L, PRC1) were also found in the gene-signature derived from the merged data sets adjusted by ComBat.
23506640	0.94	MELK, MLF1IP, PRC1, RACGAP1 and STK6.
29670361	0.93	MELK, NCAPG, PRC1, TOP2A, ZBTB41, and ZNF148) were significantly upregulated in cancer tissues.
	0.91	MELK, NCAPG, NUSAP1, PRC1, and TOP2A, was detected from the PPI network by Molecular Complex Detection.
26100469	0.90	MELK, MAD2L1, MYBL2, BIRC5, PTTG1, AURKA, PRC1, CKS2, CDCA8, MKI67, UBE2C, DUSP4, CENPF and CDC2) are found in at least 10 signatures, which indicates the great disparity across gene signatures.
21859839	0.88	MELK, PRC1, PTTG1, and TOP2A negatively correlate with patient survival (www.probesetanalyzer.com ).
32256749	0.77	PRC1), KIF20A, Rac GTPase-activating protein 1 (RACGAP1), PTTG1, ubiquitin-conjugating enzyme (UBE2C), maternal embryonic leucine zipper kinase (MELK), NUSAP1, cytoskeleton-associated protein 2 like (CKAP2L) and TK1.
31861475	0.72	MELK have been identified in glioblastoma multiforme (GBM), such as the c-JUN/MELK and MELK/PRC1 cascades, which support the survival of cancer stem cells (CSCs).
31933519	0.71	MELK, DTL, PRC1, MCM6, RUNDC1, DIAPH3, MMP9, ORC6, CDC42BPA, and DCK HCC had significant poor survival compared with patients with lower expression of those genes (Figure 4B to S).
29122991	0.70	MELK in a network with strong enrichment for key genes of the GEP-defined PR subgroup (DEPDC1, EZH2, FOXM1, NEK2, CCNB1, TOP2A, PRC1, CCNB2, and BIRC5).
	0.54	PRC1, CCNB1, CCNB2, MKI67, TOP2A, CDK1, NEK2, GTSE1) were also found to be elevated in newly-diagnosed MM patients with high MELK expression (Online Supplementary Table S1), and nine genes of the proposed network plus input genes are among the top 50 overexpressed genes of the GEP-defined PR subgroup (DEPDC1, EZH2, FOXM1, NEK2, CCNB1, TOP2A, PRC1, CCNB2, and BIRC5) (Figure 6E).
29312619	0.67	MELK (2.97), PRC1 (2.96), TOPBP1 (2.93), and STIL (2.92) were the 10 genes that had the highest combined effect sizes.
31681566	0.51	PRC1, CCNB2, AURKA, MELK, CDC20, TOP2A, and PTTG1) in NSCLC.