Publication for PRC1 and NUSAP1

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
hsa	PRC1	protein regulator of cytokinesis 1	9055			[link]
hsa	NUSAP1	nucleolar and spindle associated protein 1	51203

Pubmed ID	Priority	Text
26000042	0.98	NUSAP1-PRC1-UBE2C is very useful to develop a new route and identify novel markers and potential drugs for prognosis and therapy of lung adenocarcinoma.
	0.95	NUSAP1-PRC1-UBE2C in lung adenocarcinoma.
	0.94	NUSAP1-PRC1-UBE2C in lung adenocarcinoma.
	0.86	NUSAP1-PRC1-UBE2C in lung adenocarcinoma.
	0.67	NUSAP1_1, PTTG3, PPP1R14B, PRC1, RRM2_1, RRM2_2, TOP2A_1, MKI67_1, ASF1B, AURKA_1, AURKA_2, BUB1, CENPE, FANCI_1, HIST1H2BD_2, KIAA0101, MCM4_1, MCM4_2, CDC2_2, TPX2, MYBL2, ZWINT, UBE2C, KIF20A, CDC20, PAICS_2, CEP55, NUDT1, as shown in Supplementary Figure 1A.
	0.64	NUSAP1 (nucleolar and spindle associated protein 1), PRC1 (protein regulator of cytokinesis 1), UBE2C (ubiquitin-conjugating enzyme E2C) in high lung adenocarcinoma.
	0.50	NUSAP1-PRC1-UBE2C in lung adenocarcinoma is not clear.
20546605	0.98	NUSAP1 (nucleolar and spindle associated protein 1), PRC1 (protein regulator of cytokinesis 1) and CENPF (centromere protein F (mitosin)) which are all necessary for proper mitotic cell division.
23405241	0.97	PRC1, CDC2, CCNB2, SYCP2, PCNA, NUSAP1, TYMS, CDC20, and CDKN3) and 1 downregulated gene (CFD) was >=0.97 (Table 3).
	0.96	PRC1, CDKN3, CCNB2, SYCP2, NUSAP1 and CDC20) were also overexpressed at the protein level, the coding proteins were assessed by IH.
	0.95	PRC1, CDC2, NUSAP1, and CDKN2A were observed in both the cytoplasm and the nucleus, while signals for CCNB2 were only observed in the cytoplasm, and signals for CDC20, PCNA, and MKI67 were only observed in the nucleus (Figure 5, Figure S3).
	0.95	PRC1, SYCP2, NUSAP1, CDKN3, CDC2, CKS2, MKI67, SMC4 and ZWINT) are involved in the M phase of the cell cycle.
	0.95	PRC1, CCNB2, SYCP2 CDKN3, NUSAP1, and CDC20) associated with invasive cervical cancer that could be used either as markers for diagnosis or as therapeutic targets.
	0.88	PRC1, CCNB2, CDC20, CDKN3, NUSAP1, SYCP2, CDKN2A, PCNA, and MKI67 and FIGO staging was conducted on 42 patients with HPV16-positive CC whose progress was followed-up for at least 3.5 years after their diagnosis and initial treatment (Table 1).
	0.80	NUSAP1 (79%), MKI67, SYCP2 and PRC1 (76.9%), and CDC20 (73.1%).
	0.74	PRC1, CKS2, TYMS, RFC4, RRM2, NUSAP1, MCM2, CCNB2, SMC4, and CDC2) were selected according to Delta-score rank.
	0.73	PRC1, SYCP2, NUSAP1, CDKN3) belong to the mitosis pathway.
	0.69	NUSAP1, and CDKN3) and 5 genes that were scantly reported to be associated with CC (PRC1, SYCP2, CCNB2, TYMS, and CDC20).
	0.64	PRC1, and SYCP2 were mostly associated with CC and CDC20, NUSAP1, and CDKN3 were also associated with CIN2/3.
	0.63	PRC1, SYCP2, CDKN3, CDC20, and NUSAP1) and the 3 well-known genes (CDKN2A, MKI67, and PCNA) associated with CC are compared among the 4 groups, including healthy cervical epitheliums (Normal, n = 25), low-grade CIN (CIN1, n = 29), high-grade CIN (CIN2/3, n = 21), and invasive CC (cancer, n = 44).
	0.56	PRC1, SYCP2, NUSAP1, and CDKN3 Expression in Pre-invasive Neoplasias
22839103	0.97	NUSAP1, and PRC1, of which five were annotated to microtubule-based movement), and six genes were annotated to DNA binding (E2F8, HJURP, EXO1, ERCC6L, KIF15, KIF4A, NUSAP1), whereas no genes in the mitotic checkpoint module were annotated to these categories.
28535371	0.97	Prc1 and Ccna2), histone structure (Hist cluster genes), condensins (Smc4, Top2a, Ncaph, Smc2 and Ncapg), centromere assembly (Mis18bp1, Cenpe and Cenpa), mitotic spindle assembly checkpoint at the kinetochore (Spc25, Mad2l1, Nuf2 and Ndc80), attachment of the mitotic spindle to the centromere (Aurkb), spindle microtubule organization (Tpx2 and Nusap1), transport along the microtubule (Kif15, Kif22, Kif11, Kif20a, Kif20b and Kif23), and cell proliferation as an antigen identified by antibody Ki-67 (Mki67).
29234286	0.97	PRC1," "KIF4A," "CENPF," "NUSAP1," "KIF2C," "CEP55," "CDCA8," "CENPA," "CCNB2," "FOXM1," "UBE2C," "CDC45," "KIF15," "BUB1B," and "CDCA3"), interacted with >=5 of the hub genes, were at the hub of the PPI network.
32046048	0.96	PRC1, ASPM, NUSAP1, UBE2C, CDC20, CCNA2, and KIF20A (Figure 3).
	0.95	NUSAP1, PRC1, TOP2A, and UBE2C were also obtained via data mining of the GSE14520 dataset from the Oncomine database.
	0.90	PRC1, ASPM, NUSAP1, UBE2C, CDC20, CCNA2, and KIF20A.
23874428	0.96	NUSAP1, PRC1, SMC4, SYCE2, TFDP1, CDC42 and ARHGEF9 (CDC42 regulator) that show over-expression in lung adenocarcinoma.
	0.55	NUSAP1, PRC1, SMC4 and SYCE2 genes are involved in cell division.
20015288	0.96	NUSAP1, and PRC1 (data not shown).
26743006	0.96	NUSAP1, HMMR, CIT, ANLN, SKA3, BIRC5, PRC1) and the 6-gene Panel B (CREB1/FoxA1 downregulated genes identified in abl cells: AZGP1, CRISPLD2, EPHX2, HSPB8, PTRF, MFGE8).
30353018	0.96	NUSAP1, PBK, PRC1, RAD51AP1, STMN1 and TOP2A (Fig. 3A).
31001331	0.94	PRC1, and NUSAP1) detected in HPA database that showed almost negative staining in normal tissue but rather high expression in HCC tissue.
	0.94	PRC1, and NUSAP1 are overexpressed in HCC but are almost undetectable in non-tumorous livers.
	0.89	PRC1, and NUSAP1 have the potential to be liver biopsy-based markers for screening HCC high-risk patients with cirrhosis.
	0.82	PRC1, CCNB2, and NUSAP1 proteins expression in normal and HCC tissues from the HPA database.
	0.54	PRC1, CCNB2, and NUSAP1 were associated with HCC onset, progression, and prognosis, and exhibited higher expression in HCC compared with normal livers in the HPA database.
29670361	0.94	NUSAP1, PRC1, and TOP2A, was detected from the PPI network by Molecular Complex Detection.
	0.85	nucleolar and spindle associated protein 1 (NUSAP1), protein regulator of cytokinesis 1 (PRC1), and topoisomerase (DNA) II alpha (TOP2A).
29381681	0.93	NUSAP1-PRC1-SLC2A1-UBE2C) require the expression of ING3 (Figure 3A).
23756599	0.92	NUSAP1, PDE4B, PRC1 and thus warrant follow-up studies.
	0.83	NUSAP1, our meta-analysis of human PA array data has identified the up-regulation of genes encoding other proteins playing a critical role in mitosis, mitotic spindle checkpoint and dynamics, or cytokinesis such as BUB1, CCNB1, CDC2, KIF4, KIF11, PRC1, in gonadotroph adenomas (Supplementary Table 2).
28542306	0.92	NUSAP1, CENPF, PRC1, ASPM, DTL), and 14 more CCP genes were upregulated in the MPNST vs. NF gene signature (FOXM1, TK1, CDC20, BUB1B, PBK, CDKN3, ASF1B, CEP55, DLGAP5, RAD51, KIF11, KIF20A, PTTG1, CDCA8).
21151591	0.91	NUSAP1, ORC6L, TSPYL5, RUNDC1, PRC1, RFC4, RECQL5, CDCA7, DTL; Table 1).
30933975	0.90	NUSAP1, nucleolar and spindle associated protein 1; NTC, non-targeting control; PRC1, protein regulator of cytokinesis 1; RNA-seq, RNA sequencing; RRM2, ribonucleotide reductase regulatory subunit M2; RT-qPCR, reverse transcription quantitative polymerase chain reaction; SA-beta-gal, senescence-associated-beta-galactosidase; sgRNA, single guide RNA; SMC4, structural maintenance of chromosomes 4; TACC3, transforming acidic coiled-coil containing protein 3; TK1, thymidine kinase 1; TMPO, thymopoietin; TOP2A, DNA topoisomerase II alpha; WT, wild type; YAP, Yes-associated protein.
26992853	0.85	PRC1), microtubule spindle (KIF11, NUSAP1, NUMA1) etc.
29159069	0.82	NUSAP1, PRC1, PRKCA, PSMA1, SMC4, TOP2A, TSPO, TUBA1B, TUBB, and UBE2C) (Fig. 3C).
26975490	0.76	NUSAP1, CENPF, ASPM, BUB1B, RRM2, DLGAP5, BIRC5, KIF20A, PLK1, TOP2A, TK1, PBK, ASF1B, C18orf24, RAD54L, PTTG1, CDCA3, MCM10, PRC1, DTL, CEP55, RAD51, CENPM, CDCA8, and ORC6L) and 15 housekeeping genes using quantitative RT-PCR.
19851466	0.72	NUSAP1, ORC6L, PRC1) were also found in the gene-signature derived from the merged data sets adjusted by ComBat.
29445374	0.61	PRC1, DLGAP5, NUSAP1, and KIF20A), transcription regulation (e.g., HIST1H1B and HIST1H3B), or lymphoid activation (e.g., PBK) were upregulated in PBMCs from patients with FPF.
30847042	0.54	PRC1 (Protein Regulator of cytokinesis 1), SYCP2 (SC protein-2), NUSAP1 (nucleolar-spindle-associated protein 1), CDKN3 (Cyclin-dependent kinase inhibitor 3) that belong to the mitosis pathway.