Publication for EIF3D and EIF3I

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
hsa	EIF3D	eukaryotic translation initiation factor 3 subunit D	8664			[link]
hsa	EIF3I	eukaryotic translation initiation factor 3 subunit I	8668

Pubmed ID	Priority	Text
27210288	0.98	eIF3b and i fit well into the solenoid-shaped density (Figure 3E), suggesting that (b,i) or (b,g,i) subcomplexes are distally bound to the eIF3 PCI-MPN subunits, consistent with cryo-EM reconstructions of eIF3 in isolation and bound to the 40S ribosomal subunit.
	0.98	eIF3 subunits in crude lysates (L) or immunoprecipitate (IP) with eIF3b primary antibody from either WT or EIF3H KO (DeltaeIF3h) HEK293T cells.
	0.97	eIF3i and eIF3h can assemble into eIF3 complexes independently of each other.
	0.96	eIF3i and eIF3h may play, if any, in eIF3 assembly.
	0.92	eIF3 from lysates of either WT or EIF3H KO cell lines using an antibody for native eIF3b (Figure 4A).
20816988	0.98	eIF3b and eIF3i, and significant fragments of subunits eIF3c, eIF3d, eIF3e, eIF3f, eIF3h, and eIF3m. Notably, the predicted size of the eIF3 complexes in peak 3 (~300-400 kDa) is not consistent with all of the identified subunits being present in a unique complex.
	0.97	eIF3b within the complex, and is proximal to eIF3d and eIF3f.
	0.96	eIF3d, eIF3e, eIF3f, eIF3h, eIF3l, eIF3k and eIF3m. Interestingly, whereas the minimal eIF3/IIIabc RNA complex purified here has only weak contacts, at most, between the IIIabc domain and eIF3b, the minimal eIF3 complex contains the C-terminal two-thirds of eIF3c, and significant fragments of the non-conserved subunits eIF3e, eIF3f, eIF3h and eIF3l (Fig. 4d).
31897202	0.98	EIF3D, EIF3E, EIF3I and EIF3M promote the formation of colon neoplasms.
27924037	0.97	eIF3b neither module forms in vivo, whereas eIF3d knock-down results in severe proliferation defects with no impact on eIF3 integrity.
	0.97	eIF3b, g and i are required for a stable formation of the eIF3 holocomplex, whereas eIF3d is dispensable for stable complex formation.
	0.97	eIF3d subunits further appear to form a stable dimer prior to their joining the remainder of the complex, similar to the eIF3g:eIF3i and eIF3k:eIF3l dimers.
	0.86	eIF3b revealed again that two partial subcomplexes can form: 1) the YLC module with eIF3j alone and 2) the YLC module with eIF3j, eIF3d and the octamer lacking both its right leg (3k and l) and a part of the left leg (3h).
26344199	0.97	eIF3d, consistent with the latter's cross-linking with positions -8 to -17 on mRNA and because the only other unassigned subunit, eIF3g, constitutes part of the eIF3b/eIF3i/eIF3g module.
	0.90	eIF3d, and eIF3b sequence
	0.82	eIF3b/eIF3i/eIF3g module, and eIF3d.
30416377	0.97	eIF3b, eIF3c, eIF3d, eIF3e, eIF3f, eIF3g, eIF3h, eIF3i, eIF3j, eIF3k, eIF3l, and eIF3m. eIF3a, eIF3c, eIF3e, eIF3k, eIF3l, and eIF3m, which contain a PCI (proteasome, COP9/signalosome, eIF3) domain, and eIF3f, and eIF3h, which have an MPN (Mpr1-Pad1-N-terminal) domain, make up the octameric structural core of eIF3.
	0.96	eIF3b, eIF3d, eIF3g, and eIF3i, have a stable but flexible connection with the octameric structural core.
31118081	0.97	eIF3d and eIF3k (P = 0.001, P = 0.001) and increased levels of eIF3b, eIF3c, eIF3l and eIF3m compared to HCs (P < 0.001, P < 0.001, P = 0.004, P = 0.009, Additional file 4: Figure S1).
	0.90	eIF3b, eIF3c, eIF3d, eIF3k, eIF3l and eIF3m between RPs and CPs and found that among the six eIF3 subunits, only the expression of eIF3d was significantly altered between RPs and CPs, with the former having a lower level (P = 0.002, Fig. 1a).
20462454	0.97	eIF3b and the non-core subunit eIF3d.
21173787	0.97	EIF3D, EIF3E, EIF3F, EIF3H, EIF3I, EIF4A1, EIF4A3, EIF4B, EIF4EBP1, EIF5, EIF5B).
22585861	0.97	EIF3D (64 lines), EIF3G (57 lines), and EIF3I (54 lines).
26399914	0.97	EIF3D and EIF3G are all associated with Liver Failure, Acute Hepatitis; EIF3E, EIF3F and EIF3K are associated with Liver Neoplasms; EIF3H is associated with Carcinoma Hepatocellular; EIF3I is associated with clonorchiasis.
26593424	0.97	eIF3d/eIF3I (Figures S2A-S2E).
27256380	0.97	eIF3b, eIF3d, and eif3G) in human 293T cells .
28138064	0.97	eIF3b, eIF3d and eIF3g:in all possible combinations of 1,2, 3 and 4 of the subunits.
23766293	0.96	eIF3d (9-mer), plus eIF3d and eIF3b (10-mer) or with all eIF3 subunits except eIF3j (12-mer) (Supplementary Materials and Methods).
	0.89	eIF3b and eIF3d may contribute to additional contacts near the lower portions of domain III and the pseudoknot regions of the IRES (Figure 3).
24189219	0.95	eIF3b and eIF3g) or have being involved in direct binding to mRNA (eIF3d).
29401259	0.94	eIF3d and the WD40 beta-propeller domain of eIF3b are bound to the solvent-exposed side of 40S (Figures 1 and 2A).
	0.72	eIF3d, eIF3b and eIF3i.
27545843	0.87	eIF3D, eIF3G, eIF3I and eIF3K).
30515407	0.84	EIF3D (x7.2, FDR=0.02), EIF3E (x3.9, FDR=0.0004), EIF3F (x76.9, FDR=0.0009), EIF3G (x12, FDR<0.0001), EIF3H (x6.2, FDR<0.0001), EIF3I (x2.4, FDR=0.02), EIF3J (x25.3, FDR<0.0001), EIF3K (x3.5, FDR=0.003), EIF3L (x5.1, FDR<0.0001), EIF3M (x6.6, FDR<0.0001), EIF4A3 (x24.9, FDR=0.009), EIF4E (x-3.4, FDR=0.001), EIF4G1 (x-2.4, FDR=0.02), EIF4G2 (x-2.1, FDR=0.004), EIFG3 (x-2.66, FDR=0.003), and EIF5B (x2.8, FDR=0.005).
25539953	0.82	eIF3b, eIF3g and eIF3i subunits, resembling the budding yeast eIF3 core; a second module (ii), formed by subunits eIF3c, eIF3d, eIF3e, eIF3k and eIF3l; and a third smaller module (iii), formed by subunits eIF3f, eIF3h and eIF3m .
15790418	0.74	eIF3b, eIF3d, eIF3g, eIF3i, eIF3j) harbours a cryptic PCI domain that has eluded our detection.
18638512	0.68	eIF3b, eIF3d and eIF3f within a binary 40S-eIF3 complex.