Publication for CYP4F3 and CYP4F2

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
hsa	CYP4F3	cytochrome P450 family 4 subfamily F member 3	4051			[link]
hsa	CYP4F2	cytochrome P450 family 4 subfamily F member 2	8529

Pubmed ID	Priority	Text
21187935	0.98	CYP4F2 and CYP4F3 genes in CD pathogenesis.
	0.97	CYP4F2 & CYP4F3 genes in the region of significant linkage adds further support to our observations that they may be important candidate genes for CD.
	0.95	CYP4F2 & CYP4F3 genes are located in a cluster on chromosome region 19p13.2.
	0.93	CYP4F3 (5) and CYP4F2 (10) genes, were genotyped.
	0.93	CYP4F2 gene was more strongly associated with CD than CYP4F3.
	0.90	CYP4F2 and CYP4F3 genes in IBD pathogenesis comes from observations by Curley et al (2006) who found associations between the genes and celiac disease, a disease that bears an inflammatory phenotype similar to CD.
	0.87	CYP4F3 and CYP4F2 that are known de-activators of LTB4 .
	0.75	CYP4F3 (expressed mainly in neutrophils) and CYP4F2 (expressed largely in the liver and kidney) enzymes.
	0.68	CYP4F3 enzyme is the major LTB4 omega-hydroxylase with higher detoxification potential as compared to CYP4F2.
25370453	0.98	CYP4F2 and CYP4F3 are reported to be between 81-93% similar.
	0.95	CYP4F2 is part of a cluster of CYP4F genes on chromosome 19p13.
	0.92	CYP4F family, but in the liver CYP4F2 is the principle enzyme to omega -oxidize LTB4 to 20-OH LTB4, a far less potent eicosanoid metabolite.
	0.90	CYP4F2 may be regulated in a different manner than other CYP4F family members.
18662666	0.97	CYP4F2, one of four CYP4F P450s found in human liver and kidney.
	0.96	CYP4F primary structure revealed multiple amino acid differences (only 46% similarity) between CYP4F2 and the other CYP4F P450s amongst residues 67-114 (Fig. 1B), which comprise a region of the protein encoded by exon 3 of the corresponding structural gene.
	0.96	CYP4F2 levels and total immunoreactive CYP4F content among the 29 subjects, suggesting that the regulation of CYP4F2 protein expression in liver is not coordinate with that of CYP4F3b, CYP4F11, and/or CYP4F12.
	0.96	CYP4F2, and does not recognize the other major CYP4F P450 proteins expressed in human liver and kidney.
	0.94	CYP4F2, one of four major CYP4F P450 enzymes found in human liver and kidney.
	0.91	CYP4F+ IgG (panel B) or anti-CYP4F2 peptide IgG (panel C).
	0.90	CYP4F P450s predicts, however, that our original polyclonal CYP4F2 antibodies reacted not only with their immunogen but also with the other CYP4F subfamily members now known to be expressed in human liver and kidney.
	0.90	CYP4F2 peptide antibodies and other CYP4F subfamily members was no longer observed, regardless of the amount of these other proteins subjected to immunoblotting.
	0.86	CYP4F gene subfamily members expressed in liver and kidney, namely CYP4F2, CYP4F3b, CYP4F11 and CYP4F12.
	0.82	CYP4F P450 expressed in human liver and kidney, namely CYP4F2.
	0.81	CYP4F2 and the other CYP4F P450s are found within this particular region, especially at residues 96-100 (Fig. 1B), which is why CYP4F2 residues 89-102 and 89-101 (peptides A and B, respectively; Fig. 1A) were employed first as peptide immunogens.
	0.78	CYP4F+ IgG, which is directed against multiple antigenic sites on CYP4F2, is a potent inhibitor of reactions catayzed by this enzyme.
	0.75	CYP4F enzyme was expressed at very low levels in subjects N and J (lanes 7 and 9, respectively) while CYP4F2 levels in subject R (lane 10) were below detection.
	0.75	CYP4F gene subfamily members, an antibody produced against purified hepatic CYP4F2 recognizes not only its cognate immunogen but also CYP4F3b, CYP4F11, and CYP4F12 on Western blots (see Fig. 2)..
	0.71	CYP4F2 and total immunoreactive CYP4F (quantitated using anti- CYP4F+ IgG), suggesting that hepatic CYP4F2 expression is regulated in a manner different than that of CYP4F3b, CYP4F11, and/or CYP4F12.
	0.61	CYP4F inducers (e.g., statins) contributed to the marked interindividual variation observed in hepatic CYP4F2 levels.
28620303	0.97	CYP4F genes - CYP4F2, CYP4F11, and CYP4F12 and their effect on mRNA expression.
	0.92	CYP4F2 Variants and Hepatic mRNA Expression of the CYP4F Gene Cluster
	0.91	CYP4F2, CYP4F3, CYP4F8, CYP4F11, and CYP4F12 are almost identical, suggesting that this cluster of five genes may have evolved by gene duplication.
	0.89	CYP4F2, CYP4F11, and CYP4F12 were associated with mRNA expression in the CYP4F gene cluster.
	0.89	CYP4F2 rs2108622 in the CYP4F gene cluster do not appear to affect warfarin dose requirement.
	0.87	CYP4F2-CYP4F11 Region on Hepatic mRNA Expression of the CYP4F Gene Cluster
	0.81	CYP4F2 variants and hepatic mRNA expression of the CYP4F gene cluster are summarized in Table 2.
	0.57	CYP4F gene cluster, we conducted a comprehensive investigation looking at the effects of CYP4F2, CYP4F11, and CYP4F12 polymorphisms on the hepatic expression levels of CYP4F2, CYP4F8, CYP4F11, and CYP4F12 mRNA in a Caucasian population.
	0.50	CYP4F2 and CYP4F3B have been shown to catalyze the initial O-demethylation of the anti-parasitic prodrug pafuramidine by human liver and intestinal microsomes.
17500592	0.97	CYP4F2, CYP4F3, CYP4F8, CYP4F11, and CYP4F12.
	0.88	CYP4F2, CYP4F3, CYP4F11, and CYP4F12) or in tracheal tissue (CYP4X1), which are tissues where other xenobiotic CYP450 genes are known to function.
26653675	0.97	cytochrome P450 4F family isoform 2 enzyme (CYP4F2) has exhibited appreciable tocopherol-omega-hydroxylation activity.
25813407	0.96	20-HETE synthase in humans is CYP4F2 followed by CYP4A11.
	0.94	CYP4F2, and CYP4F3.
31480463	0.96	CYP4F2, CYP4F3, CYP4F8, CYP5F11, CYP4F12, and CYP4F22, are located on the same chromatid of chromosome 19.
	0.79	CYP4F2, CYP4F3, CYP4A11, and CYP4Z1, has been reported in various types of cancer.
24216999	0.96	CYP4F2 and CYP4A22 mRNA, which represent the main CYP isoforms producing 20-HETEs.
26233909	0.96	CYP4F2, CYP4F3A, and CYP4F3B enzymes appear to be the primary P450 omega-hydroxylases involved in the inflammatory response, therefore understanding how these CYP4F genes are regulated during inflammation may provide insight into mechanisms involved in the activation and progression of inflammatory diseases.
27451096	0.96	CYP4F2 is the predominant 20-HETE synthase in humans followed by CYP4A11.
29023376	0.96	CYP4F subfamily consists of seven human forms: CYP4F2 (liver and kidney), CYP4F3A (bone marrow and neutrophiles), CYP4F3B (liver and kidney), CYP4F8 (prostate), CYP4F11 (liver, kidney, heart, and skeletal muscle), CYP4F12 (gastrointestinal tract, heart, and kidney), and CYP4F22 (skin).
31510945	0.95	Cytochrome P450 family 4 subfamily F member 2 (CYP4F2) as a member of CYP450 superfamily, is located on human chromosome 19p13.11.
	0.79	CYP450 superfamily, CYP4F2 plays a pivotal role in the metabolism of exogenous and endogenous compounds.
22798501	0.95	CYP4F2 and CYP4F3 in eight different human cancer tissue samples (breast, colon, kidney, liver, lung, ovary, prostate and thyroid).
31514409	0.94	CYP4F2, and CYP4F3 are responsible for generating 20-HETE through omega-hydroxylation.
	0.82	CYP4F2) was confirmed to reduce 20-HETE production in vitro, and increase urinary 20-HETE excretion, and rs1126742 (F434S, CYP4A11) was first reported to reduce 20-HETE synthase activity.
23466098	0.94	CYP epoxygenases (CYP2J2 and CYP2C8), sEH (EPHX2), and CYP omega-hydroxylases (CYP4F2 and CYP4A11) are associated with the development of cardiovascular disease.
30280198	0.93	CYP4 gene expression profile in HCC and correlated the CYP4 mRNA expression levels of CYP4 subfamilies as well as the CYP4F2 protein expression level with clinicopathologic values, including prognostic factors.
	0.84	CYP4F2, cytochrome P450 family member 2; HCC, hepatocellular carcinoma.
24138531	0.93	CYP4F2 and CYP4F11
29236081	0.93	cytochrome P450 enzymes, CYP2C9 and CYP4F2, and their variants could predict approximately 15% of the variation in warfarin dose response in Caucasian populations.
25138712	0.92	CYP4F2 and CYP4F3B are involved in metabolism of the antiparasitic prodrug pafuramidine (DB289), and CYP4F enzymes are responsible for metabolism of ebastine (H1-antihistamine prodrug) in small intestine.
	0.73	CYP4F (CYP4F2/3+CYP4F11+CYP4F12) was the most abundant subfamily (48.1% of total immunoquantified CYP1-4 proteins), followed by CYP3A (CYP3A4+CYP3A5) (41.2%), CYP2J (6.9%), CYP2C(9/19) (2.0%), and CYP2D (0.2%) (Fig. 4B).
	0.59	CYP4F2/3, CYP4F11, and CYP4F12, together with cynomolgus CYP1A, CYP2A, CYP2B6, CYP2C9/19, CYP2C76, CYP2D, CYP2E1, CYP3A4, and CYP3A5 content, revealed that CYP4F (CYP4F2/3, CYP4F11, and CYP4F12) was the most abundant subfamily in small intestines, representing 48.1% of total immunoquantified CYP1-4 proteins, followed by CYP3A (41.2%), CYP2J2 (6.9%), CYP2C9/19 (2.0%), CYP1A (1.6%), and CYP2D (0.2%).
26114549	0.90	CYP4F3 is involved in promoting colon inflammation, while the increased expression of CYP4F2 would mediate disease resolution.
23688133	0.88	CYP4F2 that reportedly did not have affinity for other CYP4F enzymes, and found that CYP4F2 enzyme content varied widely in human liver (ranging from 0-80 pmoles/mg microsomal protein) with an average of 18 +- 20 pmol/mg (n= 29).
29772747	0.82	CYP4F2 and CYP4F3 were tested.
22503544	0.51	CYP epoxygenases (CYP2J2, CYP2C8), sEH (EPHX2), and CYP omega-hydroxylases (CYP4A11, CYP4F2) have been associated with cardiovascular disease susceptibility in several epidemiologic studies.
20130494	0.50	CYP4F2 genes encode cytochrome P450 enzymes that are primarily responsible for metabolizing arachidonic acid into 20-HETE, a potent vasoconstrictor.