Publication for APOL1 and APOL6

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
hsa	APOL1	apolipoprotein L1	8542			[link]
hsa	APOL6	apolipoprotein L6	80830

Pubmed ID	Priority	Text
24901046	0.98	ApoL1 and ApoL6 has indeed been proposed to be a BH3-only protein.
	0.96	ApoL1 and ApoL6 have been described to behave as proapoptotic BH3-only proteins.
	0.94	ApoL1 and ApoL6.
	0.93	ApoL1 and ApoL6, have been previously identified as BH3-only proteins.
	0.93	ApoL1 and ApoL6 also kill mammalian cells when overexpressed, and it has been proposed that all members of the family could share this ability with these two proteins.
	0.91	Apolipoprotein L1 and apolipoprotein L6 have been recently described as novel pro-death BH3-only proteins that are also capable of regulating autophagy.
	0.89	ApoL1 and ApoL6 was prevented when their BH3 motif was deleted.
	0.86	ApoL1, and its BH3-like domain is very similar to those of ApoL1 and ApoL6.
	0.82	ApoL1 and ApoL6, ApoL2 did not regulate autophagy.
26215860	0.98	APOL1 and APOL6 are toxic to human cells when overexpressed, introducing the possibility that its retention comes at a fitness cost that often outweighs its benefits.
	0.87	APOL1 and APOL6 ablated the associated cytotoxicity, suggesting that both are BH3-only pro-death proteins.
24119848	0.98	APOL1 to APOL6 gene region remains unknown.
26147622	0.98	APOL6) with apol1 MO did not rescue the edema formation of apol1 morphants (S1 Fig).
29679756	0.98	APOL1 to APOL6 gene region is still unknown and justifies further investigation.
25980612	0.97	APOL1, APOL6, TNFRSF10A, TNFRSF10D, IFI16, CD164, FCGR3A and TRIM5alpha) caused >90% reduction of p24 release by the Delta3 virus (Additional file 2: Figure S2).
	0.97	APOL1, APOL3, APOL6) were generally very potent inhibitors.
	0.93	APOL1, APOL3, APOL6 and TNFRSF10D), two additional candidates (OAS1 and IFI16) reduced the MFI of eGFP by more than 50% (Additional file 2: Figure S2 and Additional file 1: Table S1).
	0.91	APOL1, APOL6, TNFRSF10A, TNFRSF10D and CD164) achieved >90% inhibition (Figure 3E, Additional file 2: Figure S2 and Additional file 1: Table S1).
	0.79	APOL1, APOL3 and APOL6 but achieved a similar reduction in infectious virus production (Figure 3F, Additional file 2: Figure S2 and Additional file 1: Table S1).
	0.50	APOL1, APOL6, TNFRSF10A, TNFRSF10D, CD164, OAS1, CD3E and FCGR3A inhibit HIV-1 in a dose-dependent manner (Figure 4).
25561239	0.97	ApoL1 is inducible by p53 in p53-induced cell death, and overexpression of ApoL6 induces the release of cytochrome c and Smac/DIABLO from mitochondria and activation of caspase-9 via a mitochondria-mediated pathway.
	0.95	ApoL1 and ApoL6) share structural and functional similarities with Bcl-2 family proteins that play crucial roles in regulating apoptosis.
26196674	0.97	ApoL6 triggers apoptosis, which suggests that the antiviral effect of ApoL proteins may correlate with cell sensitization to apoptosis.
	0.77	ApoL6 BH3 domain with the hypothetical BH3 domain of murine ApoL proteins.
22569246	0.96	ApoL1 and ApoL6 are crucial regulators of cellular homeostasis, death and survival, and disruption of functions of these proteins may present significant clinical complications from cancer to kidney failure.
	0.94	ApoL6:ApoL1 could promote apoptosis through the inhibition of autophagic signals.
25853332	0.96	APOL6 genes are evolutionary divergent from the APOL1-4 gene cluster; it is predicted that the 3 domain organization is conserved in all the APOL family members.
	0.95	APOL6 was shown to induce apoptosis, and APOL1 can initiate autophagic cell death under certain circumstances.
29110758	0.95	APOL1, APOL3, APOL6 and TNFRS10D.
19722834	0.94	apoL gene family is split between a 127 kb cluster containing apoL-I-IV and a second cluster, containing apoL-V and apoL-VI, both of which are found on chromosome 22.
	0.93	ApoL-VI can induce apoptosis, whereas apoL-I causes autophagy when overexpressed in cancer cells, indicating a possible role for apoL proteins in host-cell death.
18632255	0.94	APOL6-APOL5-APOL3-APOL4-APOL2-APOL1-telomeric.
22573336	0.92	APOL1 locus, as well as in the APOL2-APOL6 region.