Publication for IL6ST and ANKRD55

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
hsa	IL6ST	interleukin 6 cytokine family signal transducer	3572			[link]
hsa	ANKRD55	ankyrin repeat domain 55	79722

Pubmed ID	Priority	Text
31945409	0.97	ANKRD55 and IL6ST at the risk locus on chromosome 5q11.2 in CD4+ T cells.
	0.93	IL6ST/ANKRD55, and JAZF1 in CD4+ T cells.
	0.93	IL6ST, which encodes the common cytokine receptor gp130, and ANKRD55 whose function remains unknown:and appears to do so via both intergenic (cg23343972) and intronic (cg21124310, cg10404427) CpGs.
	0.91	IL6ST and ANKDR55 in CD4+ T cells (Fig 4, C), and CIT confirmed that DNAm at 4 of these sites (cg21124310, cg10404427, cg23343972, and cg15431103) likely regulates transcription of both ANKRD55 and IL6ST.
	0.91	ANKRD55 and IL6ST is limited to RA and MS.
	0.64	ANKRD55, JAZF1, ORMDL3, FCRL3, IL6ST, C11orf10, TAX1BP1, and GSDMB as genes with potential to confer perturbed immune function via this mechanism in RA.
23382691	0.97	IL6ST-ANKRD55, ABCF2-SMARCD3, SUV420H1, and SMARCB1-DERL3).
	0.97	IL6ST-ANKRD55 (p = 1.3x10-2 for G0N) and ABCF2-SMARCD3 (p = 2.7x10-2 for G2N).
	0.97	IL6ST-ANKRD55 for galactosylation; IKZF1 for fucosylation; and SMARCB1-DERL3 for the addition of bisecting GlcNAc.
	0.96	IL6ST-ANKRD55, ABCF2-SMARCD3, SUV420H1-CHKA and SMARCB1-DERL3).
	0.94	IL6ST-ANKRD55 was significantly associated (6.88x10-11<p<2.39x10-9) with six IgG glycosylation traits, including FA2 and FA2G2 in total and neutral fractions (IGP3, IGP13, IGP43, IGP53) and the percentage of agalactosylated and digalactosylated structures in total neutral IgG glycans (IGP55, IGP57) (Figure 2).
27216775	0.97	ANKRD55/IL6ST, BLK, and PTPN22 as susceptibility genes in European populations.
23840476	0.96	ANKRD55-IL6ST (rs6859219), C5orf30/GIN1 (rs26232) and CCR6 (rs3093023); and replicate the association at PXK-FAM107A (rs13315591), although the evidence for this locus has reduced and thus needs to be further investigated in an independent population.
22661644	0.95	ANKRD55/IL6ST, BLK and PTPN22 showed association with RA susceptibility, irrespective of the serological status, the latter three markers remaining significantly associated with anti-CCP negative RA, after correction for multiple testing.
23121884	0.94	ANKRD55/IL6ST) and rs10488631 (IRF5) genotypes or proxies were not available in UKRAG.
29382131	0.93	IL6ST-ANKRD55, IKZF1, ABCF2-SMARCD3, SUV420H1, SMARCB1-DERL3 and SYNGR1-TAB1-MGAT3-CACNA1I.
21068098	0.91	ANKRD55/IL6ST, C5orf13, CCL21, CCR6, CD2/CD58, CD28, CD40, CTLA4, IL2/IL21, IL2RA, IL2RB, KIF5A, PRKCQ, PTPRC, RBPJ, REL, SPRED2, TAGAP, TRAF1/C5 and TRAF6) are part of immune response pathways, with pathways related to Th cell activation being most over-represented.
21390051	0.88	ANKRD55-IL6ST loci showed evidence of independent, second signals of association, consistent with previous reports.