Publication for TUBA1A and TUBA1B

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
hsa	TUBA1A	tubulin alpha 1a	7846			[link]
hsa	TUBA1B	tubulin alpha 1b	10376

Pubmed ID	Priority	Text
27431206	0.98	alpha tubulin 1A (TUBA1A) and the progenitor cell marker SOX1, all of which are expressed in the human neural stem cell (hNSC) line.
	0.98	TUBA1A, p.R264C TUBA1A was reported to decrease the production of TUBA1A by disturbing protein folding, which might be the reason for the difference in disease severity; that is, the shortage of TUBA1A caused by the p.R264C TUBA1A mutation could be compensated for by other interchangeable alpha tubulin isoforms via region-specific transcriptional regulation.
	0.97	microtubule-associated proteins, alpha tubulin (TUBA1A) mutations have recently been shown to cause abnormal neuronal migration.
	0.84	alpha tubulin (TUBA1A) missense mutations (Patient A, p.N329S; Patient B, p.R264C).
	0.71	alpha tubulin 1A (TUBA1A) in the genomic DNA of the iPSCs showed that the generated iPSCs had missense mutations in TUBA1A (c.986A > G in patient A-derived iPSCs, and c.790C > T in patient B-derived iPSCs); these base substitutions cause the p.N329S mutation and p.R264C mutation, respectively, in the TUBA1A protein.
30126203	0.98	TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA4A, TUBA4B, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB3, TUBB4B, TUBB6, TUBB7P, TUBB8, TUBD1, TUBE1, TUBG1, TUBG2, TUBGCP2, TUBGCP4 and TUBGCP5 is correlated with activity of their promoter chromatin.
	0.96	TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA4A but not TUBA8 and TUBAL3 interacted with the all beta-tubulin isoforms TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6 except TUBB8 (Figure 1A).
	0.95	tubulin alpha1A (TUBA1A), alpha1B (TUBA1B), alpha1C (TUBA1C), alpha3C (TUBA3C), alpha3D (TUBA3D), alpha3E (TUBA3E), alpha4A (TUBA4A), alpha4B (TUBA4B), and alpha8 (TUBA8).
	0.94	TUBA1A (0.5% of cases) and TUBA1B (0.52% of cases) were the least frequently altered tubulin genes.
	0.74	TUBA1A, TUBA1B, TUBA1C and TUBAL3 genes were not deleted in any of the samples (Figure 2).
29167382	0.98	alpha-tubulin (TUBA1A) and DAPI with a single nucleus.
	0.97	alpha-tubulin (TUBA1A).
	0.96	alpha-tubulin (TUBA1A) and Aurora B kinase (AURKB).
29556495	0.98	TUBA1A-TUBA1B mis-annotation (Supplementary Figure 2A) but also reduces the fraction of RNaseR sensitive circRNAs from 23 to 15% (Supplementary Figure 2B).
	0.97	TUBA1A-TUBA1B candidate has a suboptimal mapping quality, indicating as expected that the reads supporting TUBA1A-TUBA1B backsplicing are genomic multimappers.
	0.93	TUBA1A-TUBA1B locus, was earlier recognized as an example of closely related tandem genes where conventional splicing was misinterpreted as backsplicing between the neighboring genes (Gao et al.,).
20148114	0.98	alpha-tubulin (TUBA1A; NM_006009.2) and beta-tubulin (TUBB3; NM_006086.2) from a human fetal brain cDNA library.
	0.93	alpha-tubulin immunoprecipiated with Myc-ARX was detected by rabbit anti-alpha-tubulin antibody (raised against a common immunogen; aa 417 to 441 of TUBA1A, NP_00600.2) (Figure 7).
23358242	0.98	Tub A1A and Tub A1B) is too distant from the binding site of tyrosine.
	0.97	alpha-tubulin isoforms Tub A1A or Tub A1B is anchored by TTL via the acidic residues alphaGlu441 and alphaGlu449.
24275654	0.98	alpha-tubulin isoforms TUBA1A, TUBA1B, TUBA1C, and TUBA4A; or C, beta- or gamma-actin.
	0.98	TUBA1A, TUBA1B, TUBA1C, and TUBA4A; Fig. 2A).
26852918	0.98	alpha-tubulin (TUBA1A) was the loading control for cytosol fraction.
	0.66	TUBA1A (alpha-tubulin) was the loading control.
20974813	0.98	TUBA1A, a human alpha-tubulin isoform (blue text).
29122984	0.98	alpha-tubulin modifications (left) and sequence alignment of the C-terminal tails of human, mouse, fly, and worm TUBA1A orthologs (right).
30874545	0.98	alpha-tubulin, autophagy-related proteins, and Tau were analyzed via the String net (TUBA1A: alpha-tubulin; MAP1LC3A: LC3; MAPT: Tau; SQSTM1; P62; BECN1: Beclin1; ENSG00000258947: Tubulin beta-3 chain).
26493046	0.97	TUBA1A mutants alter the ability of alpha-tubulin to incorporate into the microtubule network
	0.97	TUBA1A was visualised as lines (Fig. 3a,B) and colocalised with the alpha-tubulin cytoskeleton (Fig. 3a,C), suggesting that FLAG-tagged wild-type TUBA1A could incorporate into the microtubule network.
	0.97	alpha-tubulin, but the puncta did not colocalise with alpha-tubulin (Fig. 3a,F,I,L), suggesting that some of the mutant TUBA1A protein could not incorporate into the microtubule network.
	0.97	TUBA1A R64W protein impaired the ability of the endogenous alpha-tubulin to repolymerise.
	0.92	alpha-tubulin followed the same order as that of FLAG-tagged TUBA1A.
	0.74	TUBA1A was visualised as lines (B) and colocalised with the cytoskeleton of alpha-tubulin (C).
	0.65	TUBA1A (A) and the overall cytoskeleton network of alpha-tubulin (B) of each cell by using the ImageJ KBI Line Extract plug-in and calculated the line density of each cell.
27994461	0.97	Tuba1a, and Tuba1b in GO-treated cells (Figure 5).
	0.97	Tuba1a, and Tuba1b.
	0.97	Tuba1a, and Tuba1b expression in GO-treated cells compared to that of the untreated cells (Student's t-test; *P<0.05).
	0.96	Tuba1a, and Tuba1b).
	0.93	Tuba1a, and Tuba1b mRNA levels compared to that in the control.
21292473	0.97	alpha- and beta-tubulin isotypes TUBA1A, TUBA8, TUBB2B, and TUBB3, all of which putatively co-assemble into neuronal microtubules.
26090378	0.97	Tubulin alpha-1A, tubulin alpha-1B, and tubulin alpha-8 chains (Figures 2(e), 2(f), and 2(g)) contain a nucleotide binding GTP site, ASN_glycosylation, and 1 Tyr-phosphomotif.
28835377	0.97	alpha-tubulin genes (51 in TUBA1A, one in TUBA3E, and eight in TUBA4A), one splicing-affecting intronic deletion in TUBA8, 48 point mutations in beta-tubulin genes (two in TUBB2A, 24 in TUBB2B, 19 in TUBB3, and three in TUBB5), and one exonic deletion in TUBB2B that produce neurological disorders in heterozygous carriers (Supplemental Table S1); all mutations, except for the TUBA8 deletion, appear to act as dominant-negative mutations.
31877708	0.97	TUBA1A, TUBA4A, TUBA1B, TUBA1C, TUBA8, and ERLIN2.
32111740	0.97	alpha-tubulin (TUBA1A) or beta-tubulin (TUBB) were individually tested for interactions with His-tagged SET8 purified from Escherichia coli.
27518565	0.96	alpha-tubulin was demonstrated by incubating SETD2 protein immunopurified using a SETD2-specific antibody with human recombinant alpha-tubulin protein (TUBA1A), followed by co-immunoprecipitation (co-IP) of alpha-tubulin (Figure 1B).
	0.89	alpha-tubulin with the GST-SETD2 fusion constructs incubated with 1mug of recombinant alpha-tubulin (TUBA1A) protein and immunoblotted using alpha-tubulin antibody (upper panel).
20920545	0.96	TUBA1A, TUBA1B, TUBA1C, TUBA4A) and kinesin genes (KIF2C, KIF4, KIF5C, KIF11, KIF18A, KIF20A).
20123021	0.95	tuba1a, tuba1b and tuba1c.
	0.74	Tuba1a and Tuba1b are separated by about 20-50kb, zebrafish tuba1a and tuba1b are only separated by about 3kb.
22036768	0.95	alpha-tubulin (TUBA1A) has been reported to cause defects in neuronal migration and axon tract formation.
22937247	0.95	TUBA1beta and TUBA3 (alpha-tubulin genes expressed in neurons) were greatly underexpressed.
24633327	0.95	TUBA1A/TUBB2A) or without (TUBA1A-DeltaY/TUBB2A) the C-terminal tyrosine (Y) on alpha-tubulin.
23246003	0.93	alpha-tubulin subunit TUBA1A have been shown to result in lissencephaly; mutations in the beta-tubulin subunit TUBB2B cause asymmetric polymicrogyria; and it has been shown that mutations in TUBB3 cause an ocular motility disorder, as well as a broad range of cortical abnormalities.
31315202	0.92	alpha-tubulin in platelets are: alpha1A (TUBA1A), alpha1B (TUBA1B), alpha1C (TUBA1C), alpha3C (TUBA3C), alpha4A (TUBA4A) and alpha8 (TUBA8).
30103319	0.91	TUBA1A, tubulin alpha-1A chain; TUBB2A, tubulin beta-2A chain; TUBA1B, tubulin alpha-1B chain; TUBB4A, tubulin beta-4A chain; SPTAN1, spectrin alpha chain, non-erythrocytic 1; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; CLTA, clathrin light chain A; STXBP1, syntaxin-binding protein 1; KRT10, keratin, type I cytoskeletal 10; CDK4/6, cyclin-dependent kinases 4/6; KRT9, keratin, type I cytoskeletal 9.
31386652	0.82	TUBA1A, TUBA1B, and TUBA1C genes are also adjacent in the genome and contain high sequence homology in both human and mouse.