Publication for Slitrk5 and Slitrk1

Species Symbol Function* Entrez Gene ID* Other ID Gene
coexpression
CoexViewer
mmu Slitrk5 SLIT and NTRK-like family, member 5 75409 [link]
mmu Slitrk1 SLIT and NTRK-like family, member 1 76965

Pubmed ID Priority Text
21315458 0.98 Slitrk1 overexpression in neurons and the analyses of the Slitrk5 and 6 null mice, suggest that multiple Slitrk members play key roles in promoting neurite outgrowth.
0.94 Slitrk5 had the broadest expression amongst the various tumors analyzed, whereas gliomas mainly express Slitrk1-3.
0.92 Slitrk1 mRNA expression was highest in the frontal lobe and Slitrk5 was expressed in both occipital and frontal lobes.
0.53 Slitrk1, Slitrk5 and SAPAP3 knockout mice.
22286174 0.97 Slitrk5-/- mice have impaired corticostriatal synaptic transmission with altered postsynaptic composition of glutamate receptors and Slitrk1-/- mice have elevated anxiety-like behavior supports the idea that multiple Slitrk family members may participate in inhibitory and/or excitatory synapse development.
20418887 0.96 Slitrk1 gene belongs to a new family of six members (Slitrk1-Slitrk6) encoding one-pass transmembrane proteins that contain two extracellular leucine-rich repeat domains, similar to Slit proteins, and a carboxy-terminal domain that is similar to Trk neurotrophin receptors.
0.85 Slitrk5 may lead to behavioral phenotypes similar to the involvement of SLITRK1 in Tourette's syndrome.
19936227 0.96 Slitrk1 through Slitrk5 are expressed broadly throughout the brain, the expression of Slitrk6 is highly restricted to thalamic nuclei.
21605970 0.96 Slitrk1 and Slitrk5 may point to a common pathway to neuropsychiatric disorders through disruption of Slitrk gene function in the CNS.
31745231 0.96 Slitrk1, Slitrk4 and Slitrk5) may differentially compensate for the effect of Slitrk2 loss.
27273464 0.91 Slitrk1 leads to increased anxiety-like behaviour, Slitrk5 mutant mice display obsessive compulsive-like behaviors, and Slitrk3 mutant mice exhibit increased susceptibility to seizures.
24821223 0.77 SLITRK5 and SLITRK1, have been shown to be associated with TS and OCD, the former in a mouse model and the latter in a TS genetic study .
27646291 0.50 SLITRK1 should be seen as contributing to construct validity of Slitrk5 null mice as a model of OC-spectrum behavior.



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