Publication for VARS1 and AARS2

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
hsa	VARS1	valyl-tRNA synthetase 1	7407			[link]
hsa	AARS2	alanyl-tRNA synthetase 2, mitochondrial	57505

Pubmed ID	Priority	Text
28675565	0.98	VARS (MIM# 192150), and VARS2 variants; (iii) thinning of the corpus callosum in patients with AARS2 (MIM# 612035), CARS2 (MIM# 612800), EARS2 (MIM# 612799), FARS2 (MIM# 611592), KARS, QARS, TARS2 (MIM# 612805), VARS, YARS, and YARS2 (MIM# 610957) variants; (iv) decreased white matter in patients with KARS and QARS variants; (v) brain stem involvement in patients with DARS2 (MIM# 610956), QARS, and RARS2 (MIM# 611524) variants; (vi) spasticity in patients with AARS, DARS, FARS2, IARS, MARS2, and RARS (MIM# 107820) variants; and (vii) sensorineural hearing loss in patients with CARS2, HARS2 (MIM# 600783), IARS, IARS2 (MIM# 612801), KARS, LARS2 (MIM# 604544), and MARS2 variants.
29573043	0.88	VARS (MIM# 192150), and YARS2 (MIM# 610957) variants; (2) failure to thrive in patients with AARS, AARS2 (MIM# 612035), CARS2 (MIM# 612800), EARS2 (MIM# 612799), IARS, LARS (MIM# 151350), MARS, MARS2, SARS2 (MIM# 612804), YARS (MIM# 603623), and YARS2 variants; (3) developmental delay in patients with AARS, FARS2 (MIM# 611592), GARS, IARS, KARS (MIM# 601421), LARS, MARS, MARS2, NARS2 (MIM# 612803), PARS2 (MIM# 612036), QARS, RARS2 (MIM# 611524), SARS2, VARS, and YARS variants; (4) hypotonia in patients with CARS2, EARS2, HARS2 (MIM# 600783), IARS, KARS, LARS, MARS, MARS2, QARS, RARS (MIM# 107820), RARS2, SARS2, TARS2 (MIM# 612805), and YARS variants; (5) abnormal or decreased white matter in patients with AARS, CARS2, DARS (MIM# 603084), DARS2 (MIM# 610956), EARS2, GARS, IARS, KARS, MARS2, NARS2, QARS, RARS, RARS2, and YARS variants; and (6) liver dysfunction in patients with EARS2, FARS2, IARS, LARS, LARS2 (MIM# 604544), MARS, and YARS variants.