Publication for VARS1 and VARS2

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
hsa	VARS1	valyl-tRNA synthetase 1	7407			[link]
hsa	VARS2	valyl-tRNA synthetase 2, mitochondrial	57176

Pubmed ID	Priority	Text
31623496	0.97	VARS2 gene contains 30 exons and encodes mitochondrial valyl tRNA-synthetase, which participates in mitochondrial protein synthesis.
30709774	0.96	VARS2 variant (p.R334X) exclusively in the proband's nuclear genome, which maps in the gene encoding the mitochondrial valyl-tRNA synthetase.
31064326	0.95	VARS2, a nuclear gene encoding for valyl-tRNA (Val-tRNA) synthetase, are associated to several forms of mitochondrial encephalopathies or cardiomyoencephalopathies.
28675565	0.93	VARS2 (MIM# 612802), and YARS (MIM# 603623) variants; (ii) microcephaly in patients with AARS, IARS, KARS (MIM# 601421), NARS2 (MIM# 612803), PARS2 (MIM# 612036), QARS, VARS (MIM# 192150), and VARS2 variants; (iii) thinning of the corpus callosum in patients with AARS2 (MIM# 612035), CARS2 (MIM# 612800), EARS2 (MIM# 612799), FARS2 (MIM# 611592), KARS, QARS, TARS2 (MIM# 612805), VARS, YARS, and YARS2 (MIM# 610957) variants; (iv) decreased white matter in patients with KARS and QARS variants; (v) brain stem involvement in patients with DARS2 (MIM# 610956), QARS, and RARS2 (MIM# 611524) variants; (vi) spasticity in patients with AARS, DARS, FARS2, IARS, MARS2, and RARS (MIM# 107820) variants; and (vii) sensorineural hearing loss in patients with CARS2, HARS2 (MIM# 600783), IARS, IARS2 (MIM# 612801), KARS, LARS2 (MIM# 604544), and MARS2 variants.
30940487	0.92	VARS2: valyl-tRNA synthetase, USP37: deubiquitinase) to chaperones (DNLZ, COL4A3BP) to a transmembrane signaling protein (TSPAN15).
30262995	0.87	valyl-tRNA synthetase (VARS2, class I enzyme) has been shown to restore the steady-state levels of tRNAVal resulting from 1624 C>T in Leigh disease.
29314548	0.85	VARS2, encoding the mitochondrial valyl tRNA-synthetase, were first reported in a patient with psychomotor delay and epilepsia partialis continua associated with an oxidative phosphorylation (OXPHOS) Complex I defect, before being described in a patient with a neonatal form of encephalocardiomyopathy.
30755602	0.84	VARS paralogue functions in the cytoplasm and VARS2 paralogue functions in the mitochondria to charge valine tRNAs.
24827421	0.60	VARS2, the gene encoding the mitochondrial valyl tRNA-synthetase.
24639874	0.59	VARS2, the gene encoding the mitochondrial valyl-tRNA synthetase (mt-ValRS), has been found in a child with psychomotor delay, seizures, and facial dysmorphisms.