Publication for STAT1 and UBE2L6

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
hsa	STAT1	signal transducer and activator of transcription 1	6772			[link]
hsa	UBE2L6	ubiquitin conjugating enzyme E2 L6	9246

Pubmed ID	Priority	Text
29857509	0.98	STAT1 and STAT2) and two ubiquitination-related enzymes (UBA7 and UBE2L6).
	0.98	STAT1, STAT2, UBA, and UBE2L6 in Participating in Apoptosis Induced by Furosine
	0.98	STAT1/STAT2/UBA7/UBE2L6 SiRNAs, respectively, the apoptosis rates were lower than the control/ NC group/ single staining group (p < 0.05).
	0.98	STAT1 and STAT2 in the cell nucleus increased, the fluorescence signal of UBA7 in the cell nucleus weakened, and the one of UBE2L6 seemed to exhibit no obvious change, when comparing them with the control.
	0.98	UBE2L6) in the furosine treatment groups were expressed significantly higher than the control, and the protein levels of the six factors (STAT1/2, P-STAT1/2, UBA7, UBE2L6) in the furosine treatment groups were expressed significantly higher than the control, suggesting that furosine activated the phosphoralation of STAT1 and STAT2 and expressions of UBA7 and UBE2L6, which were the downstream sponsor of STAT1 and STAT2, in a dosage-dependent manner.
	0.98	STAT1/2, UBA7, and UBE2L6 at protein level; (B) Furosine up-regulated expressions of STAT1/2, UBA7, and UBE2L6 at mRNA level; (C) Furosine up-regulated expressions of Caspase-3/9, Bax, and Bcl-2 at protein level; (D) Selection of high-efficient SiRNA fragment in HepG2 cells.
	0.97	STAT1/STAT2/UBA7/UBE2L6 + furosine (100 mg/L), there seemed to be no obvioius up-regulation of apoptosis rates compared with the STAT1/STAT2/UBA7/UBE2L6 SiRNAs groups.
	0.97	STAT1/2, UBA7, UBE2L6, Caspase-3, Bcl-2, Bax, and Caspase-9 affected by furosine.
	0.96	STAT1, STAT2, P-STAT1, P-STAT2, UBA7, and UBE2L6 in the whole cells increased significantly (p < 0.05) with the treatment of furosine, in a dose-dependent manner, when compared with the control (Figure 3A,B).
	0.96	STAT1 and STAT2 entered into the cell nucleus with the aim of regulating the expression of several apoptotic proteins after the stimulation of furosine; UBA7 usually locates in the whole cell, and it tended to translocate into cell cytosol and degradate proteins in apoptosis course in the furosine treatment group; UBE2L6 always locates in cell cytosol and still participates in protein degradation in cytosol, so its location seemed to display no change with the treatment of furosine.
	0.95	STAT1, STAT2, UBA7, and UBE2L6, etc.
	0.92	STAT1 and STAT2) and two ubiquitination-related enzymes (UBA7 and UBE2L6).
	0.89	STAT1, STAT2, P-STAT1, P-STAT2, UBA7, and UBE2L6 proteins in the whole HepG2 cells increased significantly (p < 0.05) with the treatment of furosine.
	0.56	STAT1, STAT2, UBA7, and UBE2L6, which might play a key role in participating cell apoptosis induced by furosine.
26695443	0.98	STAT1, STAT2, UBE2L6, ZNFX1) selected from the IFN/STAT1 signature was measured 3 (D3) and 7 days (D7) following AC treatment in 9 TNBC that respond to AC and 5 TNBC and 1 HER2-positive non-responder PDXs by qPCR (Figure 3).
	0.86	STAT1, STAT2, UBE2L6, ZNFX1) at D7 and D14.
24833526	0.97	UBCH8 and of other IFN/STAT1 targets (ISG15 and STAT1 itself) in the IFNalpha-treated cells (Fig. 2B).
	0.95	STAT1-dependent transcription of the UBE2L6 gene and a subsequent accumulation of UBCH8 in cells.
	0.76	STAT1 and STAT3 are not degraded upon induction of UBCH8 or SIAHs is consistent with other E3 ubiquitin ligases catalyzing STAT1 turnover.
31877408	0.97	STAT1, GBP2, and UBE2L6, all of which were found to be upregulated DEGs in this study (Figure S4).
28635624	0.96	UBE2L6, a ubiquitin gene, and STAT1 were trans-regulated by the same T1D SNPs located in the 12q24 locus, as also confirmed in peripheral blood.
29643425	0.96	STAT1, TAP1, BST2, UBE2L6, PHF11 & IFI16.
24013639	0.94	STAT1, UBE2L6 and UPP1).
17935622	0.93	UBCH8 and HERC5, the anti-viral interferon-inducible genes PKR (EIF2AK2), MX1, and RIG1, signaling proteins in the JAK-STAT pathway including JAK1, ERK1 and STAT1 and IRF3, which plays a major role in the innate anti-viral response.
30336493	0.93	UBE2L6 (p = 0.004), FCGR1B (p = 0.012), GBP1 (p = 0.013), IL1B (p = 0.015), MYD88 (p = 0.018), TLR8 (p = 0.02), IRF7 (p = 0.028), STAT1 (p = 0.032), SERPING1 (p = 0.036), and IFIT2 (p = 0.037)) were included in the subsequent analyses.
29040650	0.89	UBE2L6, and HERC5 gene expression via activation of signal transducer and activator of transcription-1 (STAT1) protein.
	0.60	UBE2L6, and HERC5, and whether such effect was mediated by further downstream STAT1 activation.
	0.55	STAT1-mediated upregulation of UBA7, UBE2L6, and HERC5 as a potential mechanism in the ISG15-dependent reduction in neurogenesis by IFN-alpha.
24391741	0.88	Stat1 and Ube2l6 were elevated only in hippocampal neurons and Psmb9 in prefrontal cortical neurons (Figure 1A).
15287976	0.85	STAT1 and UBE2L6.
29686423	0.81	STAT1, XAF1, CTNNB1 and UBE2L6.