Publication for STAT1 and IFI44

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
hsa	STAT1	signal transducer and activator of transcription 1	6772			[link]
hsa	IFI44	interferon induced protein 44	10561

Pubmed ID	Priority	Text
17488182	0.98	STAT1, IFIT1, and IFI44, were significantly reduced in expression in patients with melanoma versus healthy controls.
	0.97	STAT1, IFI44, and MX2 in stimulated versus unstimulated cells (calculated using the Pfaffl method) was higher in the melanoma patient samples (Figure 4B).
	0.95	STAT1, IFIT1, IFI44, and MX2 and showed the lowest fold changes for these genes, and the lowest response to IFN-alpha in the Phosflow assay out of the group of patients with melanoma, further indicating that some of these patients are IFN-low-responders.
	0.95	STAT1, IFIT1, IFI44, and MX2 were measured by qPCR.
	0.85	STAT1, IFIT1, IFI44, and MX2.
	0.50	STAT1: n = 13 (H), n = 11 (M); IFIT1: n = 12 (H), n = 12 (M); IFI44: n = 13 (H), n = 11 (M); MX2: n = 12 (H), n = 12 (M).
29526079	0.98	IFI44 did not correlate with the level of STAT1 phosphorylation (Fig. 3B).
	0.97	STAT1 phosphorylation was not significantly associated with IFI44.
	0.95	STAT1 phosphorylation by type I and II IFNs than that of other antiviral ISGs, such as IFI44, IFI27, or myxovirus resistance-1 (Mx1).
	0.95	IFI44 and the level of STAT1 phosphorylation might be attributed to the limited number of patients enrolled.
20088942	0.98	STAT1, STAT3, p44/42, Akt and p38 phosphorylation was determined by western blotting (A).
	0.97	STAT1, STAT3 or p44/42 eliminated the effect of OSM on Ang2 expression (Fig. 3B), whereas blockers of the p38 (10 mum SB-202190) and PI3K/Akt (10 mum LY-294002) pathways did not inhibit OSM-induced Ang2 expression, suggesting the involvement of the JAK/STAT and MAP kinase pathways.
	0.91	STAT1 phosphorylation, of piceatannol (200 mum) on STAT3 phosphorylation, and of U0126 (1 mum) on p44/42 phosphorylation.
31455651	0.98	STAT1/STAT2 leads to the induction of ISGs with antiviral activities, including IFI44.
	0.92	IFI44 decreases the ability of IKKepsilon to phosphorylate IRF-3 (and most probably IRF-7 and STAT1) (Fig. 7A and data not shown) and the ability of IKKbeta to phosphorylate IkBalpha (Fig. 7B).
	0.67	STAT1/STAT2 leads to the induction of ISGs with antiviral activities, including IFI44 (Fig. 8).
22242177	0.98	STAT1 pathway: STAT1, IFI44, IFIT3, OAS1, IFIT1, ISG15, MX1, and USP18.
	0.98	STAT1 signaling cascade, and indeed MX1, IFI44, ISG15, OAS1, and STAT1, which are predicted to be up-regulated with increased Interferon signaling, are shown to have significantly increased hazard ratios in the single gene analysis (Figure 1 and Table 1).
17502666	0.98	IFI44, STAT1, and IRF-7 (Table S1).
23299892	0.98	IFI44 and IFI44L) that are induced downstream of STAT1-STAT2 showed patterns of defective expression in CMC patients compared to healthy controls, supporting a role of the type I IFN pathway in this immunodeficiency (Fig. 5).
30186768	0.98	STAT1, IFI44, IFIT3, OAS1, IFIT1, ISG15, MX1, and USP18, was also shown to predict poor outcomes in glioblastomas post RT.
19594299	0.97	STAT1, GBP1, interferon gamma receptor 2 (IFNGR2), signal transducer and activator of transcription 2 (STAT2), guanylate binding protein 2 (GPB2), chemokine (C-X-C motif) ligand 10 (CXCL10), interferon-induced protein 44 (IFI44), interferon-induced protein 44-like (IFI44L), tumor necrosis factor (ligand) superfamily member 10 (TNFSF10), interferon-induced protein 35 (IFI35), and interferon-induced protein with tetratricopeptide repeats 2 (IFIT2) genes had higher expression in the low BMD group.
	0.97	STAT1, IFI44L, CXCL10, IFI44, GPB1, and GPB2 genes were expressed in higher levels in the low BMD group than in the high BMD group, which is very similar to the IFN-induced gene expression pattern (IFN pathway).
	0.97	STAT1, IFI44L, CXCL10, IFI44, and GPB1.
	0.89	STAT1, IFI44L, CXCL10, IFI44, GPB1, and GPB2.
25947293	0.97	IFI44 (Fig. 4B) but also increased the phosphorylation level of JAK1 induced by poly(dA:dT) (Fig. 4C), indicating that SHP-1/2 is involved in dsDNA-triggered activation of JAK1-STAT1 signaling.
	0.97	STAT1 inhibitor Fludarabine for 1 h prior to tansfection with poly(dA:dT), poly(dG:dC) or ISD for 6 h. The expression levels of IFIT1, IFI44, MX1 and OAS1 were detected by qPCR.
	0.79	STAT1 inhibitor Fludarabine and the JAK1 inhibitor Baricitinib significantly reduced dsDNA-induced expression of IFIT1, MX1, OAS1 and IFI44 (Fig. 1D).
	0.67	STAT1 signaling in B cells, we transfected the synthetic dsDNA analogs, including poly(dA:dT) (B-form DNA), poly(dG:dC) (Z-form DNA) and ISD (interferon stimulatory DNA), into the human B cell line BJAB cells for 6 h. As shown in Fig. 1A, transfection with poly(dA:dT), poly(dG:dC) or ISD could induce considerable expression of IFIT1, MX1, OAS1 and IFI44.
21035159	0.97	STAT1, ISG15, MX1, OAS1, OAS2, IFI44 and IFI44L) in the peripheral blood and lung tissue of both groups.
	0.96	STAT1, MX1, OAS1, OAS2, ISG15 and IFI44 in lung necropsies of IFN-alpha2b injected and SARS-CoV infected ferrets (Fig. 4 ).
	0.76	STAT1, MX1, OAS1, USP18, RSAD2, ISG15 and IFI44 were upregulated in the peripheral blood of IFN-alpha2b-injected and SARS-CoV-infected ferrets.
22367717	0.97	IFI44, IFIT3, IFITM1, LGALS3BP, MX1, STAT1 are upregulated in all studies, regardless of species, microarray, and means of analysis.
	0.96	IFI44, IFIT3, MX1, STAT1) are still significantly elevated in the brain despite treatment.
	0.58	IFI44, IFIT3, MX1, STAT1.
26695443	0.97	STAT1 is itself able to activate and prolong transcription of IFN-inducible genes, including IFI27, IFI44, OAS1 and BST2,, and STAT1 can function as a transcription factor in the absence of tyrosine phosphorylation.
	0.95	IFI44, IFI44L, IFI6, IFIT1, IFIT3, IFITM1, IRF9, MX1, OAS1, OAS2, PARP12, PARP9, SAMD9, STAT1, STAT2, UBE2L6, ZNFX1) at D7 and D14.
	0.91	STAT1-target proteins: IFI44, LCN2, and OAS1 was also increased in residual tumour cells in two out of three models, as compared with untreated or regrowing tumours (Figure 1D).
23918204	0.97	p44/42 MAPK, Stat1 or beta-actin (as internal control).
	0.93	p44/42 MAPK and Stat1(Ser727) is induced and the activation continues for at least 1h (Fig. 7).
30012562	0.97	IFI44, NLRP3, CCL5, STAT1, CCL4, IFI35, IRF9, ISG15, IFNG, and MX1, among others.
	0.97	IFI44, MX1, STAT1).
31798636	0.97	STAT1, STAT2, IFIH1, EIF2AK2, TDRD7, IFI44, PARP12, FLJ20035, PARP14, ISGF3G, XAF1, RSAD2,LY6E, IFI44L, and DDX58) were identified.
	0.95	STAT1, STAT2, IFIH1, EIF2AK2, TDRD7, IFI44, PARP12, FLJ20035, PARP14, ISGF3G, XAF1, RSAD2,LY6E, IFI44L, and DDX58 had high gene significance for SS (Figures 2C, D).
22383882	0.97	STAT1 activates and prolongs the expression of a number of IFN-induced immune regulatory genes like IFI27, IFI44, OAS, and BST2.
31323891	0.96	p44/42 MAPK, phospho-PTEN, STAT3, Akt, STAT1, pTEN, NFkB, IGF-I receptor B, MEK1/2, mTOR, RelB, MET, HER3, and phospho-eIF4B.
32256826	0.96	IFI44, IFIT2 and IFI6), and several pattern recognition receptor-associated genes [IRF7, STAT1 and CXCL10 ], as well as some genes involved in invasion and metastasis of cancer cells [HGF, IGF1, KIT, FN1 and CXCL12 ].
23882263	0.95	IFI44, IFI6, MX1, MyD88, RARRES1, STAT1 and TLR3 and the primers that were used for amplification of the transcripts corresponding to the selected genes are found in Table 2.
24260178	0.95	STAT1-57 genes, there was strong overrepresentation of genes involved in response to virus (e.g., DDX58, DDX60, EIF2AK2, HERC5, IFI35, IFI44, IFI44L, IFIT1, IFITM1, IRF9, ISG15, MX1, MX2, OAS2, OAS3, PLSCR1, STAT1 and TRIM22; P = 8.4x10-16).
25417103	0.95	STAT1, MX1, ISG15, OAS1, IFIT1, IFIT3, IFI44) identifies patients whose cancers are resistant to chemo and RT.
20966397	0.93	p44/42 MAPK activity, but not STAT1.
28129744	0.93	STAT1 (Fig. 4)]; c) IFN signaling related to inflammation [MICB, IRF9, ISG20, STAT1, TAP1, MX2, IFI44, PTPN6 (Fig. 3b)]; d) Cytokine related pathways (28 in total) (Fig. 3c) (IL-13 signaling (STAT1, PTPN6, STAT6, PRKCD] and IL-2 activation (NFKB2, HMGA1, PTPN6 and SYK, among others).
23593264	0.92	ISGF3, IFI44, and GBP1, have not been associated with any disease yet and may be exploited for drug development for scleroderma in the future.
24188121	0.91	interferon-induced protein 44 (IFI44), interferon-stimulated protein 15KD (G1P2), interferon regulatory factor 1 (IRF1), 2'-5'-oligoadenylate synthetase 3 (OAS3), signal transducer and activator of transcription 1 (STAT1), interferon stimulated protein 35 (IFI35), Myxovirus resistance 1 (MX1), interferon-induced protein with tetratricopeptide repeat 4 (IFIT4), interferon-induced protein with tetratricopeptide repeat 1 (IFIT1), and interferon-induced protein with tetratricopeptide repeat 2 (IFIT2).
30374345	0.51	IFI44, HDH2D, Mx1, OAS2, CD40, TRAF2, TRADD,TLR2, TLR3, MyD88, CL22, IL15, C2, CFB, RIPK2, STAT1, STAT2, STAT3, MAPK8, and MAPKAP2, with a highly positive and significant correlation (R > 0.8, p < 0.0001***).