Publication for SRSF2 and SRSF7

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
hsa	SRSF2	serine and arginine rich splicing factor 2	6427			[link]
hsa	SRSF7	serine and arginine rich splicing factor 7	6432

Pubmed ID	Priority	Text
29317634	0.98	SRSF2 (one sample), and SRSF7 (one sample).
	0.98	SRSF2, SF3A1, and SRSF7) lie between the SF3B1 and BAP1 clusters and may therefore represent intermediate transitional cases or uncommon non-canonical trajectories.
	0.58	SRSF2, SF3A1, and SRSF7) mapped to subclones.
22419818	0.98	SC35/SRSF2 (serine/arginine-rich splicing factor 2) or 9G8/SRSF7 (serine/arginine-rich splicing factor 7).
27768896	0.98	SRSF7, SRSF2 mobility was not influenced either by mCherry-PR50 or mCherry-GR50, suggesting that GR and PR specifically impact the dynamics of proteins they interact with (Figure S7).
15907217	0.97	SC35 and 9G8 had an opposite effect (lanes 3-4).
	0.97	SC35 or 9G8) were immuno-stained, examined and counted using Confocal Laser Scanning Microscopy (see figure 4).
	0.97	SC35 on an ESS2-containing transcript have no effect on 9G8 binding to the same substrate.
	0.96	SC35 and 9G8 together with HIV-1 strongly affected the full length viral RNA splicing pattern, notably resulting in a strong reduction of the genomic RNA and Env mRNA levels.
	0.95	SC35 and 9G8 caused a large accumulation of Tat mRNAs, it is likely that these two SR proteins act by distinct mechanisms.
	0.94	SC35 and 9G8 preferentially enhanced splicing at site A3 necessary for Tat mRNA synthesis (Figure 1).
	0.94	SC35 (Figure 4C) and 9G8 (not shown) SR proteins had less pronounced effects since a majority of the cells coexpressed Gag and one SR protein (Figure 5; 45 to 55 % see bars labelled gag+SC35 and gag+9G8, respectively) or evenly in the case of Gag, Env and 9G8 (Figure 5; see bar labelled gag+env+9G8).
	0.93	SC35 is up-regulated and 9G8 down-regulated in HIV-1 infected cells.
	0.92	SC35 or 9G8 (ratios indicate molar amounts of HIV-1 DNA vs SR-expressing vector).
	0.92	SC35 and 9G8, profoundly affected the HIV-1 splicing pattern (Figure 1), resulting in a drastic decrease of virus production.
	0.91	SC35 or 9G8 inhibited viral protein synthesis, notably that of the structural proteins Gag and Env (Figures 3, 4, 5) and consequently, virion production (Figure 6A).
	0.88	SC35 or 9G8 coding plasmid, a majority of cells expressed Gag and the SR protein (see SC35 and 9G8 bars).
	0.86	SC35 and 9G8 Vpr was hardly detected in virions in agreement with the very low level of Vpr mRNA and protein in cells (Figure 3B lanes 3-4).
	0.82	SC35 and 9G8 had an opposite effect (Figure 3B).
	0.61	SC35 and 9G8, respectively, as compared with control HIV-1 cells (Figure 3A).
	0.61	SC35 or 9G8.
20840771	0.97	SFRS2 and SFRS7.
	0.97	SFRS2, SFRS7 and SFRS10) were significantly enriched for alternate exon usage indicating auto-regulatory organization at the level of transcript splicing.
	0.80	SFRS2, SFRS7, SFRS10, RBM25, U2AF2, SNRPB, PRPF31 and DDX39).
11448987	0.97	SC35, SF2/ASF, SRp20, and 9G8.
	0.95	SC35, p80 Coilin, WT1, 9G8, SF2/ASF, SRp20, SRp30c, and SRp40.
25970345	0.97	SC35, SRp20 or 9G8 did not elicit a similar nuclear sequestration of HIV-1 US RNA (Fig 6), indicating that the response to Tra2beta/Tra2betaDeltaN overexpression is not a general response to SR overexpression but is limited to a least a subset of proteins within the SR family.
	0.85	SC35 (GFP SC35), SRp20 (GFP SRp20), or 9G8 (GFP 9G8).
29433383	0.97	SRSF7, SRSF8, SRSF9, SRSF10, and SRSF11 did not show any significant changes in regulation, but the expression levels of SRSF2 and SRSF3 were significantly down-regulated.
	0.73	SRSF2, SRSF3, SRSF7, SRSF8, SRSF9, SRSF10, and SRSF11) and splicing factors (SYF2, PSF, SRp75, and SF3a) in THP-1 cells post M. tb infection.
22844237	0.97	SC35, SRp20, 9G8, Htra2-beta, PTB and NOVA.
21082031	0.96	SC35 (gene: SFRS2), SRp20 (gene: SFRS3), SRp75 (gene: SFRS4), SRp40 (gene: SFRS5), SRp55 (SFRS6), and 9G8 (SFRS7) constitute the group of "classical" SR proteins.
	0.92	SC35 (SFRS2), Sp20 (SFRS3), SRp75 (SFRS4), SRp40 (SFRS5), SRp55 (SFRS6), and 9G8 (SFRS7).
31576545	0.96	SRSF2, SRSF7, and/or hnRNPF) in EA PCa promotes inclusion of exon 20 in the final transcript of PIK3CD-L and generation of the PIK3Cdelta-L protein (Fig. 5).
	0.60	SRSF2, SRSF7, and HNRNPF, with increased expression in AA PCa compared to EA PCa at both the mRNA and protein levels (data not shown).
20574110	0.95	Sfrs2, Sfrs5, and Sfrs7 bind to the carbohydrate mimic, I-peptide.
	0.58	Sfrs2, Sfrs5, and Sfrs7 as carbohydrate-binding receptors, several other lines of evidence are consistent with the notion that SR proteins are expressed at the cell surface of endothelial cells.
19965769	0.95	SC35, but not that of 9G8, interacted with RNA probe IIB (lanes 1-5).
21183462	0.95	9G8 and SC35 were detected in complexes formed with NRSs 24 and 26, suggesting that both the SLS1 and SLS4 sequences are required for efficient binding of SR proteins.
26431027	0.95	SRSF2, SRSF3, SRSF5, SRSF6 and SRSF7) (black line), plotted with the corresponding standard deviations (grey bars) and compared to SRSF1's binding profiles derived with three different SRFS1 motifs (red and blue lines) in the present RNA-seq dataset.
21609956	0.94	9G8, Tra2alpha/beta, SF2/ASF and SC35 as proteins important for selection of this splice site (Figure 6A and data not shown).
	0.92	9G8, SC35 and Tra2alpha/beta were associated with pathogenic activation of the GC 5'ss in BTK intron 3.
	0.67	9G8, SC35 and Tra2beta in 293 T cells.
25506695	0.94	SRSF2, SRSF3, SRSF4, SRSF5, SRSF6, SRSF7, SRSF9 n = 6; SRSF11 n = 5. (C) Immunoblot analysis of protein lysates from HeLa cells transfected with the indicated expression vectors.
	0.94	SRSF2, SRSF3, SRSF7, and SRSF9 probed with a T7-specific antibody, endogenous SRSF4, 5 and 6 probed with SRSF4-, SRSF5- and SRSF6-specific antibodies and FLAG-tagged SRSF11 probed with a FLAG-specific antibody.
23341853	0.94	SC35) and SFRS7 (9G8).
31879760	0.93	SRSF2 and SRSF7, HNRNPA1 and HNRNPA1L2 have been found enriched in retained introns.
	0.90	Srsf2, Srsf7 and Fus.
	0.89	Srsf2 (7.44 motifs per thousand nucleotides in dIR introns compared to 2.32 in other introns), Srsf7 (2.3 over 0.49).
	0.87	Srsf2, Srsf7 and Tra2a, is among the most affected by dIR itself (dIR = 0.29).
19857271	0.93	SC35, SRp20, SRp40, SRp55, SRp75, SRp30c, 9G8, and SRp54 - have a common structural organization (Figure 1), containing either one or two amino-terminal RNA-binding domains that provide RNA-binding specificity, and a variable-length RS domain at their carboxyl terminus that functions as a protein interaction domain.
29684050	0.91	SRSF2, SRSF3, SRSF5, SRSF7, U1snRNP70, Tra-2beta, hnRNPA2/B1, hnRNPI, hnRNPL, hnRNPH, hnRNPE2 and hnRNPA1.
31775037	0.91	SRSF7, SRSF12, and TRA2beta; (2) mutated TP53 with SRSF3, SRSF12, and TRA2beta; (3) amplified or upregulated PIK3CA with TRA2beta; (4) upregulated HRAS with SRSF2, SRSF3, SRSF4, SRSF7, and SRSF9; and (5) upregulated BRCA1 or BRCA2 with SRSF1, SRSF10, SRSF12, and TRA2beta (Table S1D).
23747814	0.88	SRSF2, SRSF3, SRSF7 and TRA2B; see Table 5), which are known to be master regulators of alternative splicing.
20227104	0.84	9G8 fluorescence was seen in speckled structures that colocalized with SC35 in mock-infected cells and in cells infected with KOS, 27-LacZ and d2-3 (Fig. 4A).
28152302	0.84	SRSF7), SRSF2 is a non-shuttling protein located in the nucleus.
24069033	0.75	SRSF7 by DYRK1A induces their cytoplasmic translocation, whereas phosphorylation of SRSF2 and SRSF6 causes their dissociation from nuclear speckles.
26930004	0.70	SRSF2/SC35, SRSF3/SRp20, SRSF7/9G8 in breast tumors shows that the expression of hnRNP A1, but not the other tested RBPs, is associated with metastatic relapse.
24406341	0.69	SRSF2, we found that SRSF1 (SF2/ASF), SRSF3 (SRp20) and SRSF7 (9G8) were able to stimulate the luciferase activity that depended on their tethering to the MS2 binding sites in the reporter (Fig. 3B).
30864659	0.63	SRSF2, SRSF4, SRSF5, SRSF6, SRSF7 and Prp8 remained in nuclear speckles, whereas SRSF1, SRSF3, U1-70K and U2AF65 were mostly nucleoplasmic (Figure 11 and Supplementary Figure S8).
23525660	0.57	SC35 is renamed as SRSF2; and SRp20, SRp75, SRp40, SRp55, and 9G8 are now known as SRSF3 to SRSF7, respectively.
28592444	0.51	SRSF7 shuttle in both cell types; however, SRSF2 and SRSF5 did not shuttle when HeLa cells were donors, indicating that the NRS was functional.