Publication for FUS and SRSF2

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
hsa	FUS	FUS RNA binding protein	2521			[link]
hsa	SRSF2	serine and arginine rich splicing factor 2	6427

Pubmed ID	Priority	Text
27906075	0.97	SC35 speckles and also co-aggregation of FUS with TDP-43.
	0.97	SC35 speckles, along with co-aggregation of TDP-43 and FUS, could contribute to pathogenesis in FSHD, perhaps by locally interfering with genetic and epigenetic regulation of gene expression in the small subset of nuclei that express high levels of DUX4-FL at any one time.
	0.96	SC35 speckles, we found that DUX4-FL expression led to the formation of FUS aggregates in nuclei.
	0.95	SC35 speckle dysfunction or co-aggregation of FUS with TDP-43.
	0.89	SC35 speckle structures and to prevent nuclear co-aggregation of FUS and TDP-43.
	0.64	SC35 speckles plus FUS.
29134320	0.97	SRSF2 (also known as SC-35, ranked 5) is a nuclear speckle component that potentially interacts with TDP-43, FUS and the G4C2 repeat expansion and has been shown to co-localize with 34% of C9 antisense RNA foci in cerebellar Purkinje cells of C9-ALS patients.
	0.91	SRSF2 and Syncrip can be found within supplemental tables of unbiased proteomic screens for potential interacting proteins of TDP-43, FUS and Ataxin2 (Table 4), these supplemental data were not available to Watson's analysis that focused on published abstracts.
23023293	0.97	FUS/TLS molecules bound to these introns may facilitate transcription elongation, similar to what has been shown for another RNA-binding protein, SC-35.
27033831	0.97	FUS in RNA splicing is further underscored by the identification of FUS as an direct interacting partner with splicing factors, SC35 and SRSF10 (serine/arginine-rich splicing factor 10), and as one of the ~50 non-snRNP proteins in the pre-spliceosome.
24353314	0.96	FUS/TLS associates with other splicing factors including YB-1, SR proteins SRSF2 and TASR, polypyrimidine tract-binding protein or hnRNP I and C1/C2.
29598823	0.96	FUS; SRSF2; RBM5; PCBPI1; and PCBPI2 (Table 2).
29618456	0.96	FUS, and SC35; leads to accumulation of dsRNA and nuclear aggregation of EIF4A3; and inhibits nonsense-mediated decay.
18698352	0.95	SC35 and SRp40 are known to enhance p19 H-Ras alternative splicing, we also analyzed whether the RNAi-mediated depletion of hnRNP A1, FUS/TLS, hnRNP H and p68 affect SR proteins mRNA levels.
	0.92	FUS/TLS or hnRNP H (Table 1) led to upregulation of SFRS2IP, a SC35-binding protein.
	0.91	SC35 was not regulated by any of these RNAi-mediated depletions, a SR protein that specifically binds to SC35, namely SFRS2IP, was upregulated by RNAi-mediated depletion of hnRNP A1, and to a lesser extent by the RNAi-mediated depletions of FUS/TLS and hnRNP H. These findings suggest that these three proteins may regulate a feedback loop involving SC35 via SFRS2IP.
	0.87	FUS/TLS, hnRNP H and p68 alter the activity and dynamic localization of SC35 and H-ras alternative splicing.
28762175	0.94	FUS interacts with several factors involved in splicing such as the U1-snRNP splicing complex, the SMN complex, SC35, SRSF1, SRSF3, and SRSF10 (Sun et al.; Shang and Huang).
31879760	0.58	Srsf2, Srsf7, Snrnp70, Sfpq and Fus).