Publication for POLQ and CLSPN

Species Symbol Function* Entrez Gene ID* Other ID Gene
coexpression
CoexViewer
hsa POLQ DNA polymerase theta 10721 [link]
hsa CLSPN claspin 63967

Pubmed ID Priority Text
23552402 0.98 POLQ (95%CI 2.6-517.4, P=0.008), 23.5 for PLK1 (95%CI 1.9-288.4, P=0.01), 20.7 for CLASPIN (95%CI 1.5-275.9, P=0.02) and 18.5 for CDC6 (95%CI 1.3-267.4, P=0.03).
0.98 POLQ, PLK1, RAD51, CLASPIN and CDC6 separates patients into low- and high-risk groups, with a hazard ratio of 14.3 (95% CI 5.1-40.3, P<0.001).
0.98 POLQ, PLK1, RAD51, CLASPIN or CDC6 did not correlate (P>0.05, Supplementary Table S3) with the therapeutic strategy or with the number of metastasis-containing nodes.
0.98 CLASPIN and POLQ genes promotes cancer progression by increasing resistance to endogenous replication stress in a concerted manner.
0.97 POLQ, CLASPIN and CHK1 (T/N>3), CDC45, CDC6, KI67, HMGA2 and CDT1 (T/N>4) and PLK1 (T/N>5).
0.96 POLQ, CDC6 and PLK1, and to a lesser extent CLASPIN and RAD51, behave as a single 'metamarker' (Supplementary Figure S2B).
0.96 POLQ, PLK1, RAD51, CLASPIN and CDC6 genes, either considered individually or as a signature, is associated with a bad prognosis in NSCLC.
0.95 POLQ, PLK1, RAD51, CYCLIN A, CDC25A, CLASPIN and CDC6 (Supplementary Table S2).
0.95 POLQ, PLK1, RAD51, CLASPIN and CDC6 was associated with overall, disease-free and relapse-free survival (Table 3).
0.94 POLQ, PLK1, RAD51, CLASPIN and CDC6 was associated with overall, disease-free and relapse-free survival.
0.92 POLQ, PLK1, RAD51, CLASPIN or CDC6.
0.89 POLQ, PLK1, CLASPIN, RAD51 and CDC6 genes on the resistance to replication stress.
0.82 POLQ, PLK1, CLASPIN and CDC6), except RAD51 (Table 4), presumably because RAD51 expression correlates with that of PCNA and KI67 (Pearson's coefficients rho=0.54 and rho=0.81, respectively).
0.72 POLQ (P=0.0008), PLK1 (P=0.0062), RAD51 (P=0.007), CYCLIN A (P=0.0128), CDC25A (P=0.0196), CLASPIN (P=0.0233), CDC6 (P=0.0404), POLL (P=0.0464) and RPA (P=0.0458).
32104698 0.83 CLSPN, E2F2, and POLQ (Figure 4(b)).



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