Publication for WDR35 and WDR19

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
hsa	WDR35	WD repeat domain 35	57539			[link]
hsa	WDR19	WD repeat domain 19	57728

Pubmed ID	Priority	Text
28400947	0.98	IFT121 showed reduced IFT43 and similar levels of IFT144 (N = 3).
	0.95	IFT121 mutations found decreased IFT43 levels (Fig. 6c, d) and normal levels of IFT-A core complex member IFT144 (Fig. 6c, e), indicating that while the IFT121 mutations caused instability of the satellite component IFT43, they did not affect overall IFT-A core stability.
	0.93	IFT144, and three satellite components, IFT43, IFT121, and IFT139, as shown in Fig. 3e.
	0.90	IFT144, undetectable levels of satellite members IFT121 and IFT139, and abnormal cytosolic localization of IFT43.
	0.83	IFT144/WDR19 [OMIM 608151], IFT122/WDR140/WDR10 [OMIM 218330], IFT121/WDR35 [OMIM 613610], and IFT43 [OMIM 614099] that has thus far only been associated with CED.
	0.50	IFT144 (WDR19), IFT121 (WDR35), IFT139 (TTC21B), can produce CED, SRPS, a distinctive form of EVC, and ATD overlapping phenotypes that imply disruption of similar biological mechanisms when the IFT-A complex is defective.
29068549	0.98	WDR35, IFT122, TTC21B, IFT140, and WDR19) and other ancillary proteins.
	0.98	WDR19 and WDR35 (Fig. 3), underscoring the functional importance of these domains.
	0.97	WDR19 and IFT140) and two peripheral (satellite) proteins (WDR35 and TTC21B), were identified in 14 (9%) of the families (Supp.
	0.97	WDR19, WDR35 and TTC21B) proteins showing the locations of the mutations identified in this study.
26130459	0.98	WDR19, WDR34, WDR35, WDR60 and TTC21B) or the basal body region (NEK1, EVC, EVC2).
	0.98	WDR19 = SRTD5 and CED4; WDR35 = SRTD7 and CED2; WDR34 = SRTD11; WDR60 = SRTD8; DYNC2H1 = SRTD3; DYNC2LI1 = novel intermediate phenotype of our patients).
25506500	0.98	WDR19, TTC21B, IFT140, IFT122, IFT80, IFT43, and WDR35) or components of the retrograde IFT motor complex dynein-2 (i.e. DYNC2H1, WDR34, and WDR60).
27932497	0.97	IFT144 and IFT43/IFT121/IFT139, respectively.
	0.95	IFT144, mChe-IFT121/IFT122, and mChe-IFT43 were detected (Figure 3C, top, lane 4).
	0.91	IFT144, which is associated with TULP3, and a peripheral subcomplex, composed of IFT43/IFT121/IFT139, where IFT139 is most distally located.
	0.91	IFT121, IFT122, IFT139, IFT140, and IFT144; Figure 1A) are larger than most IFT-B subunits.
	0.73	IFT144 (Figure 1E) and IFT43, IFT121, or IFT122 (Figure 1F), respectively.
	0.57	IFT144 and the IFT43-IFT121 dimer.
22689656	0.97	IFT144/Wdr19 and IFT122 were core components of the mammalian IFT-A complex, whereas IFT139/Ttc21b and IFT121/Wdr35 were peripheral proteins that were not required for the formation of the core complex.
	0.96	IFT121/WDR35, IFT43, IFT122, IFT144, and IFT140:cause human ciliopathies, whereas disease-causing mutations have been identified in only a single IFT-B gene.
	0.92	IFT144, IFT139 (Ttc21b), IFT140, IFT121 (WDR35), IFT43, and IFT144 (WDR19).
	0.92	IFT121/WDR35, IFT43, IFT122, IFT144/WDR19, and IFT140:have recently been shown to cause a set of related human genetic syndromes, including short-rib polydactyly, Jeune asphyxiating thoracic dystrophy, Sensenbrenner syndrome/cranioectodermal dysplasia, and Mainzer-Saldino syndrome (:).
27806291	0.97	Wdr35, IFT43, and IFT144 suggest that the IFT-A complex acts in concert to transport these cargoes.
	0.73	IFT144, into cilia, suggesting that interactions with Wdr35 were essential (Figure S2D), in contrast with the relatively minor impact on IFT88 (IFT-B) import (Figure 1F).
	0.61	Wdr35 also regulated the retrograde transport of many proteins with diverse functions, including other IFT-B subunits (IFT54 and IFT20), anterograde IFT motor Kif3A, IFT-A subunits (IFT140 and IFT144), BBsome subunits (BBS4 and BBS5), and the Hedgehog (Hh) pathway-associated transcription factor, Gli2 (Figures 1F-1H and S2B-S2F).
	0.55	Wdr35 functions independently or in concert with the IFT-A complex to transport cargoes, we knocked down IFT43 and IFT144 in RPE1 cells and examined the localization of three cargoes (IFT88, BBS4, and Arl13b) (Figures 3A-3D, S3A and S3B).
22118932	0.97	IFT144, IFT140, IFT122 and IFT121 protein sequences are predicted to have a remarkably similar domain organization with the N-terminal regions containing WD-repeats that are known to fold into beta-propellers, while the C-terminal part is predicted to contain alpha-helical TPR repeats (Fig. 1).
	0.93	IFT144/WDR19, IFT140 and IFT122 that remained associated after knockdown of the other two IFT-A components IFT139/THM1 and IFT121/WDR35.
20441589	0.97	WDR35, and WDR19); (3) Nine from the Complex B module (IFT88, IFT80, IFT172, IFT57, CLUAP1, IFT52, IFT20, IFT81, and IFT74); (4) Six from the BBS complex (BBS5, TTC8, BBS2, ARL6, BBS1, and BBS7) (Figure 1).
23456818	0.97	WDR35/IFT121 and WDR19/IFT144 that are all part of the IFT-A protein complex.
25830415	0.97	WDR19, WDR35, TTC21B, and DYNC2H1) or basal body homeostasis (NEK1, EVC, and EVC2).
27453244	0.97	WDR19/NEK1/WDR35/WDR60/IFT140/IFT172/WDR34/CEP120/KIAA0586.
27666822	0.97	WDR19 [OMIM 608151], WDR34 [OMIM 613363], WDR35 [OMIM 613602], WDR60 [OMIM 615462], TTC21B [OMIM 612014], IFT172 [OMIM 607386] and IFT80 [OMIM 611177].
28724397	0.97	WDR35, IFT122, WDR19, and IFT140.
26931514	0.96	IFT144/WDR19 and WDR35 and IFT-B components IFT172 and IFT80 are detected as ancestrally related to COPI subunits, yet without a connection to nucleoporins or a reference to the ACE1 structural motif.
24465567	0.95	WDR35 (IFT121), and WDR19 (IFT144; Figure 3B).
22829176	0.93	WDR35 , WDR19, and C5ORF42 as causes of Sensenbrenner and Joubert syndromes respectively.
	0.81	WDR35/IFT121, TTC21B/IFT139, WDR19/IFT144, IFT140, IFT43, and DYNC2H1, a subunit of the cytoplasmic dynein motor 2.
30320547	0.92	IFT144, -140, -139, -122, -121/WDR35, and -43)) driven by dynein-2.
	0.58	WDR19/IFT144 and WDR35/IFT121) and two BBSome components (BBS7 and BBS9) were identified to interact with HA-WDR34 and their binding to HA-WDR34 was reduced in the absence of WDR60.
28698599	0.91	IFT121 (also known as WDR35), IFT122, IFT139 (also known as TTC21B), IFT140 and IFT144) are associated with several skeletal ciliopathies, including Jeune asphyxiating thoracic dystrophy (JATD), cranioectodermal dysplasia (CED; also known as Sensenbrenner syndrome) and short-rib polydactyly syndrome.
30479745	0.91	WDR19, which combined with the peripheral subcomplex, that includes IFT43, WDR35, and TTC21B, forms the functional IFT-A complex.
27925158	0.89	WDR19 (OMIM 608151), WDR34 (OMIM 613363), WDR35 (OMIM 613602), WDR60 (OMIM 615462)], IFT140 (OMIM 614620), TTC21B (OMIM 612014) and TCTEX1D2], the IFT-B anterograde transport complex [IFT80 (OMIM 611177) and IFT172 (OMIM 607386)], basal body and centrosomal proteins [EVC1 (OMIM 604831), EVC2 (OMIM 607261), KIAA0586 (OMIM 610178) and CEP120 (OMIM 613446)], a planar cell polarity component [INTU (OMIM 610621)], as well as kinases and related ciliary molecules [ICK (OMIM 612325), NEK1 (OMIM 604588)], C21ORF2 (OMIM 603191), among the skeletal ciliopathies.
	0.80	IFT144, IFT140, IFT139, IFT122, IFT121, and IFT43) that act as adaptors between the dynein motor and associated cargos.
32007091	0.88	WDR35, IFT140, IFT43, IFT52 and WDR19.
	0.86	WDR35, IFT140, IFT43, IFT52 and WDR19) have been associated with this syndrome.
25635582	0.88	IFT121, IFT122, IFT139, IFT140, IFT144) were published for Jeune, cranio-ectodermal and Mainzer-Saldino syndrome (Fig. 4, Table 3).