Publication for St14 and Cldn7
| Species | Symbol | Function* | Entrez Gene ID* | Other ID | Gene coexpression |
CoexViewer |
|---|---|---|---|---|---|---|
| mmu | St14 | suppression of tumorigenicity 14 (colon carcinoma) | 19143 | [link] | ||
| mmu | Cldn7 | claudin 7 | 53624 |
| Pubmed ID | Priority | Text |
|---|---|---|
| 29617460 | 0.99 | matriptase has been shown to cleave EpCAM in cultured intestinal epithelial cells, causing premature degradation of the tight junction protein claudin-7. |
| 0.98 | claudin-7 expression in Spint2-/-;Prss8R44Q/R44Q mice mimic closely molecular changes induced by unregulated matriptase activity in HAI-2-silenced intestinal cell monolayers. | |
| 30623107 | 0.98 | matriptase axis in the intestinal epithelial cells and dysregulation of this axis results in excess Epcam cleavage by matriptase and destabilization of the Epcam/claudin-7 complex. |
| 0.96 | matriptase-selective synthetic inhibitor ZFH7185-8 suppressed the Hai-2 loss-induced Epcam cleavage in a dose-dependent manner, accompanying stabilization of claudin-7 (Fig. 9c). |
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