Publication for Cldn4 and Cldn7

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
mmu	Cldn4	claudin 4	12740			[link]
mmu	Cldn7	claudin 7	53624

Pubmed ID	Priority	Text
23284647	0.98	Cldn4 and Cldn7), Wnt ligands (Wnt7A, Wnt7B), and possibly microRNA (miR-200s).
	0.95	Cldn4, Cldn7, Dsg2, Gjb3, Tjp2, Esrp1, Rab25, and Epcam (Figure 4J).
	0.85	Cldn7, Cldn4, Cldn3, Ocln and Tjp2), desmosomes (Dsp, Jup, Pkp2 and Dsg2), gap junction (Gjb3), cytokeratine (Krt7, Krt8, Krt14, Krt17 and Krt19), Integrin (Itgb6, Itgb4 and Itgb2), Wnt ligands (Wnt7A, Wnt7B) and epithelial specific splicing factor (Esrp1).
31835702	0.98	CLDN4, and CLDN6 in mouse embryos and knockdown of CLDN7 in pig embryos (unpublished data) disrupts paracellular sealing.
	0.97	CLDN4, CLDN6, CLDN7, TJP1, TJP2, F11R, and CDH1 in YAP knockdown embryos (p < 0.05; Figure 5A, middle panel).
	0.96	CLDN4, CLDN6, CLDN7, TJP1, TJP2, and F11R), adherens junction formation (CDH1), and fluid accumulation (AQP3 and ATP1B1).
21761342	0.98	Cldn4, Cldn7, and Cldn8 were the most abundantly expressed Claudin transcripts in prostate epithelium, and found that Cldn4 (mean difference of the cycle threshold numbers is 3.266 +- 0.6151; p<0.01) and Cldn8 (mean difference of the Ct numbers is 0.9158 +- 0.3793; p<0.033) transcripts were significantly decreased following castration (Figure 1).
	0.98	CLDN4, CLDN7, and CLDN8 were abundantly expressed in normal prostate epithelium, and determined that CLDN4 (mean difference of Ct numbers is 3.603 +- 0.6654; p<0.001) and CLDN8 (mean difference of Ct number is 6.532 +- 1.492; p<0.001) were significantly decreased following castration (Figure 3A,B).
25951797	0.98	claudin-4 and claudin-7, are more ubiquitously expressed throughout the respiratory epithelium.
	0.96	claudin-7 and claudin-4 expression and function.
21803035	0.98	Cldn4, Cldn7, and Emp1 (Table I).
22162632	0.98	claudin-4, and claudin-7 and represses the expression of those genes, thereby inducing EMT.
23610556	0.98	claudin 4, and claudin 7 expressions in trophoblast cells at the base of the chorion.
30648119	0.98	claudin-4, claudin-7, and occludin, as well as a notable increase in claudin-2 expression.
30910700	0.98	Cldn4, and Cldn7 were significantly increased in the stomach of stCldn18-/- mice (Figure 7A), and these Cldns are known to be highly expressed in intestinal epithelial cells.
31905642	0.98	Cldn-4, Cldn-7, Cldn-8) is expressed, and each of these claudins has been implicated in mediating aspects of the specific properties of its tight junction.
28455726	0.97	Claudin-4 was widely distributed throughout the cytoplasm and localized at least to some extent with occludin and claudin-7 relocated in part from the basal and lateral membranes to the apical region of the alveolar cells.
	0.71	Claudin-7 continued to be present in numerous cytoplasmic puncta while claudin-4 disappeared entirely from the epithelium except for strong basolateral localization in an occasional epithelial cell.
29617460	0.97	claudin-7, claudin-1 and E-cadherin, but an increase in gene and protein expression of claudin-4.
	0.96	claudin-7, and an increased expression of claudin-4 on postnatal days 2 and 4.
24526818	0.97	claudin-4, claudin-7 and claudin-8 are expressed in the collecting duct cells acting as chloride permeability determinants.
25118157	0.96	CLDN 4, CLDN 7, CLDN 11, and CLDN 23 (Table 1).
	0.93	CLDN4, CLDN7, and CLDN23 were all significantly increased.
32093310	0.96	CLDN4, and CLDN7 is downregulated.
28698546	0.95	claudin-4 (p < 0.05), claudin-7 (p < 0.001) and claudin-15 (p < 0.01) decreased significantly in HFD-mice compared to the ND-mice (Fig. 2(b and d)).
	0.94	claudin-4 and claudin-7 proteins in control cells were largely decreased but it demonstrated cytosolic presence for claudin-3 protein (Fig. 5(e)).
	0.92	claudin-4, claudin-7 and occludin (p < 0.05 for each proteins versus control cells) were also observed in DCA-treated cells (Fig. 5(c and d)).
	0.87	claudin-7 expression (p < 0.05) but increased claudin-2 (p < 0.05), claudin-3 (p < 0.05) and claudin-4 expressions significantly (p < 0.01) (Fig. 6(c and d)).
31257542	0.95	claudin-4, a pore-sealing claudin, and claudin-7, -12 and -15, which are regarded as pore-forming claudins that permit cation flux.
27215490	0.94	Claudin-4 mRNA expression was significantly increased in IL-13 overexpressing transgenic mice and claudin-1 and claudin-7 mRNA levels were not different between the genotypes (n=6 in each group) (Figure 5B).
22073304	0.93	claudin-4 and claudin-7 in UC, whereas expression of claudin-2 was increased, as claudin-1 and claudin-3 expression levels were unchanged in controls and active UC.
	0.92	claudin-4 and claudin-7, and an increased expression of claudin-2 in UC, as claudin-1 and claudin-3 expression levels were unchanged in controls and active UC.
31435172	0.93	claudin-4 and claudin-7 in a murine model of DSS-colitis.
31382627	0.92	CLDN7-/- CD cells, CLDN7 KD induced an increase in WNK4 and SGK-1 expression while AQP2, CLDN3, and CLDN4 expressions were unchanged (Figure 5B,C).
	0.69	CLDN7 CD cell lines, CLDN4 was well localized to the cell junction area in both CLDN7+/+ and CLDN7-/- CD cells, though the CLDN8 signal was undetectable.
20659473	0.92	Claudin-7, we investigated the localization and expression of Claudin-4, a functional component of tight junctions in the small intestine.
23140368	0.91	claudin-4 or claudin-8 was not affected in claudin-7 knockout mice, ruling out the possibility that claudin-7 is part of the paracellular Cl- channel complex.
22691877	0.90	claudin-4 and claudin-8 are expressed in most epithelia of the body, the constitutive KO strategy will generate claudin KO phenotypes confounded by its extrarenal functions, which may also lead to perinatal death or developmental defects as observed in claudin-7 KO mice.
	0.75	claudin-4 or claudin-8 was not affected in claudin-7 KO, ruling out the possibility that claudin-7 was part of the paracellular Cl- channel complex.
21377456	0.82	Claudin 4, Claudin 6 and Claudin 7.