Publication for Cldn3 and Cldn7

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
mmu	Cldn3	claudin 3	12739			[link]
mmu	Cldn7	claudin 7	53624

Pubmed ID	Priority	Text
31248104	0.98	Cldn-3 has previously been shown to be affected by HF diets and commensal bacterial colonization, while Cldn-7 has been found to have functions outside of barrier integrity, such as maintenance of intestinal homeostasis, and both its mRNA and protein are highly expressed in the small and large intestine.
	0.97	Cldn-3 and Cldn-7) in the male fetal gut (p < 0.05, Figure 9, Figure 10 and Figure 11) compared to CON.
	0.97	Cldn-3 and Cldn-7 are the amongst the most highly expressed in all sections of the mouse GI tract.
	0.97	Cldn-7, but not Cldn-3, mRNA expression, which might suggest an attempt to increase barrier integrity to compensate for the gut barrier immaturity.
	0.96	Cldn-3, Cldn-7), and reduced expression of an AMP-activator (Tlr4).
	0.95	Cldn-3 (p = 0.008, Figure 7A) and Cldn-7 (p < 0.001, Figure 7B) compared to CON, while UN fetuses only displayed increased mRNA expression of Cldn-7 compared to CON (p < 0.001, Figure 7B).
	0.95	Cldn-3 and Cldn-7, however these data run counter to the effects of HF diets on TJ expression in adult mice and rats.
	0.94	Cldn-3 nor Cldn-7 have been recorded in mouse fetal guts.
	0.94	Cldn-7 (p < 0.001) in fetal gut vs. CON, while fetuses from HF mothers increased Cldn-3 (p = 0.008) and Cldn-7 (p < 0.001) mRNA expression vs. CON (n = 9-15/group).
	0.64	Cldn-3 (p = 0.02) and Cldn-7 (p = 0.004), while maternal UN was associated with increased Cldn-7 (p = 0.004); in female fetal guts, maternal UN was associated with increased Cldn-3 (p = 0.03) mRNA expression (n = 3-8/group).
24526818	0.98	claudin-3, claudin-7 and claudin-15 were observed in villous epithelial cells corresponding to the severity of histological changes while leaving the abundance of these claudin subspecies unchanged in crypt cells.
	0.97	claudin-3 and claudin-7, claudin-12 and claudin-15 are expressed in the epithelial cells of the mouse jejunum.
	0.97	claudin-3 and claudin-15 were expressed in the apical-most region in villous and crypt epithelia, whereas claudin-7 was observed throughout the lateral membrane of villous and crypt epithelia (Fig. 2).
	0.97	claudin-3, claudin-7 and claudin-15 decreased in the villous epithelium roughly in parallel to the severity of injury (Fig. 2).
	0.80	claudin-3, claudin-7 and claudin-15 were maintained (Fig. 2).
18663477	0.98	Cldn3, Cldn5, Cldn7, and Cldn23) were slightly up-regulated (2.2-2.5 fold increase in expression level) in the double mutants, in comparison to wt mice (Fig. 4b).
	0.97	Cldn3, Cldn5, Cldn7, and Cldn23 (Fig. 4b).
22178591	0.98	claudin-3 and claudin-7 in P5 Prox1DeltaPanc pancreata (Supplementary Figure 2B).
	0.98	claudin-7 and claudin-3 in Prox1-deficient pancreata at P5 (Supplementary Figure 2A).
18593559	0.98	claudin 3 (Cldn3), claudin 7 (Cldn7), occludin (Ocln), and E-cadherin (Cdh1) within 24 hr of induction (day 3), with further inhibition on day 4 (Figure 2B).
20182541	0.98	claudin-3, claudin-7 protein expression also decreased in parotid glands from female AQP5-/- mice, further indicating a relationship between claudins and water transport during saliva secretion.
21761342	0.98	CLDN3, CLDN4, CLDN7, and CLDN8 were abundantly expressed in normal prostate epithelium, and determined that CLDN4 (mean difference of Ct numbers is 3.603 +- 0.6654; p<0.001) and CLDN8 (mean difference of Ct number is 6.532 +- 1.492; p<0.001) were significantly decreased following castration (Figure 3A,B).
22162632	0.98	claudin-3, claudin-4, and claudin-7 and represses the expression of those genes, thereby inducing EMT.
31905642	0.98	Cldn-3, Cldn-4, Cldn-7, Cldn-8) is expressed, and each of these claudins has been implicated in mediating aspects of the specific properties of its tight junction.
22073304	0.97	claudin-3, claudon-5, claudin-7 and claudin-8, and also increased expression of colonic claudin-2.
	0.96	claudin-3, claudin-5, claudin-7 and claudin-8 in colitis mice were markedly decreased as compared with control mice.
	0.95	claudin-3, claudin-5, claudin-7 and claudin-8 were markedly decreased after DSS administration, whereas colonic claudin-2 expression was significantly decreased.
	0.94	claudin-3, claudin-5, claudin-7 and claudin-8 in UC.
	0.94	claudin-3, claudin-5, claudin-7 and claudin-8 expressions, and also decreased colonic claudin-2 in colitis mice.
	0.93	claudin-3, claudin-5, claudin-7 and claudin-8 expressions, and also decreased colonic claudin-2 in colitis mice.
	0.93	claudin-3, claudon-5, claudin-7 and claudin-8, decreased of colonic claudin-2 expression in DSS-induced colitis.
	0.92	claudin-7 in UC, whereas expression of claudin-2 was increased, as claudin-1 and claudin-3 expression levels were unchanged in controls and active UC.
	0.89	claudin-7, and an increased expression of claudin-2 in UC, as claudin-1 and claudin-3 expression levels were unchanged in controls and active UC.
	0.87	claudin-3, claudin-5, claudin-7 and claudin-8 was predominantly distributed along the cellular membrane, and the immunofluorescent intensity remained unchanged after CXCL12 or AMD3100 treatment.
	0.87	claudin-3, claudon-5, claudin-7 and claudin-8 in colon tissue.
28698546	0.97	claudin-3 (p < 0.05) and claudin-7 (p < 0.05) expressions characterized renal epithelium in obese mice.
	0.95	claudin-3 (p < 0.05), claudin-4 (p < 0.05), claudin-7 (p < 0.001) and claudin-15 (p < 0.01) decreased significantly in HFD-mice compared to the ND-mice (Fig. 2(b and d)).
	0.94	claudin-3, claudin-4 and claudin-7 proteins in control cells were largely decreased but it demonstrated cytosolic presence for claudin-3 protein (Fig. 5(e)).
	0.86	claudin-7 expression (p < 0.05) but increased claudin-2 (p < 0.05), claudin-3 (p < 0.05) and claudin-4 expressions significantly (p < 0.01) (Fig. 6(c and d)).
23626786	0.97	claudin-3, presumably caused by phosphorylation and participation of claudin-7 in alveolar TJs, was recognized in parallel with the leakage of fluorescein isothiocyanate-conjugated albumin (FITC-albumin) via the alveolar epithelium.
	0.97	claudin-7 in alveolar TJs and qualitative changes in claudin-3, which occur presumably by phosphorylation.
	0.95	claudin-3 and claudin-7 12 h after LPS injection.
30828892	0.97	claudin 3, claudin 7, and MUC2 mRNA expression (Figure 4C).
	0.97	claudin 3, claudin 7, MUC2, cryptidin, and defensin, was downregulated in CA-treated Apc min/+ mice.
32093310	0.97	CLDN3, CLDN7, and CLDN15, while the expression levels of other CLDNs are weak or non-existent.
	0.97	CLDN3, CLDN4, and CLDN7 is downregulated.
23766441	0.97	claudin-7 expression while expression of claudin-3,-4,15, Occludin, E-cadherin, and beta-catenin remained largely unaltered (Figure 1E,1F and S2-B).
26755160	0.97	Cldn3, Cldn7 and Cldn15), which have been shown to directly regulate epithelial permeability by forming paracellular channels (see Fig. S3a in the supplemental material).
28194015	0.97	Cldn3, Cldn4, Cldn7), and higher expression levels of many EMT-related genes (for example, Twist1, Zeb1, Cdh2 and Vim; Fig. 4f).
28783170	0.97	claudin-3 expression to be the highest compared to claudin-1, claudin-2, claudin-7, Occludin, ZO-1, E-cadherin, beta-catenin and beta1-integrin (p<0.01; Fig-1A and Supplementary Fig-S1A).
28793255	0.97	Claudin-3 and Claudin-7 were mostly expressed in ductal cells and at lower levels in endocrine and acinar cells (Figures 3B and 3E, respectively).
17945025	0.95	Cldn3, Cldn4 and Cldn7 has been observed in some tumors, suggesting that methylation could also play a role.
21924257	0.95	Cldn3, Cldn6, Cldn7), adherens junctions (Cdh1, Cdh16) and desmosomes (Eppk1, Dsg2) are found among the 113 genes present in TLCEG (Table 3).
27173853	0.95	Cldn3, Cldn6, Cldn7, Crygc, Dmd, Krt19, Krt6a, Krt7, Krt8, Upk1b and Wwc2 (fig. 2; http://www.gudmap.org/gudmap/pages/focus_insitu_browse.html?batchId=368).
31435172	0.93	claudin-3, claudin-4 and claudin-7 in a murine model of DSS-colitis.
	0.92	claudin-3 and claudin-7 and reduced lipopolysaccharide-binding protein plasma concentration.
22691877	0.93	claudin-3 in the mouse collecting duct cell had no significant effect on PCl or PNa, while knockdown of claudin-7 resulted in a 30% decrease in TER but no significant change in paracellular ion selectivity (PCl/PNa), indicating a TJ barrier-function defect.
31382627	0.92	CLDN7-/- CD cells, CLDN7 KD induced an increase in WNK4 and SGK-1 expression while AQP2, CLDN3, and CLDN4 expressions were unchanged (Figure 5B,C).
30863148	0.88	CLDN3 and CLDN7 downregulation was more pronounced in the mesenchymal CMS4 and in the stem cell phenotype-like C4 subtypes.
23284647	0.85	Cldn7, Cldn4, Cldn3, Ocln and Tjp2), desmosomes (Dsp, Jup, Pkp2 and Dsg2), gap junction (Gjb3), cytokeratine (Krt7, Krt8, Krt14, Krt17 and Krt19), Integrin (Itgb6, Itgb4 and Itgb2), Wnt ligands (Wnt7A, Wnt7B) and epithelial specific splicing factor (Esrp1).
21372174	0.80	claudin-3 in Eph4 cells was slower than in SF7 cells, with a rate similar to that of claudin-7, probably because claudin-3 was integrated into TJs in the Eph4 cells (Figure 7).
27490784	0.80	claudin-3 was without any noticeable effect on either PCl or PNa, while knockdown of claudin-7 led to a global loss of barrier function against both Na+ and Cl-.
28455726	0.78	Claudin-3 mRNA expression roughly paralleled that of claudin-7 in glands from virgin and pregnant animals.
22069652	0.72	claudin-3 with greater affinity than a murine claudin-7 peptide, yet full length CPE equivalently recognizes HEK293 cells transfected with either claudin-3 or claudin-7, based on cell killing assays.
23140368	0.70	claudin-3 and claudin-7, Hou et al knocked down their expression in the collecting duct M-1 and mIMCD3 cells.