Publication for IRF8 and TLR7

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
hsa	IRF8	interferon regulatory factor 8	3394			[link]
hsa	TLR7	toll like receptor 7	51284

Pubmed ID	Priority	Text
17935622	0.97	IRF8 through potential interaction with the TLR7 pathway and through ISGF3 via activation of the type 1 interferon receptor.
	0.94	IRF8 in signaling of TLR7 has not been elucidated.
26160613	0.95	TLR7/TLR9-mediated responses are damaging in SLE, IRF8 and SLC15A4 are not exclusively expressed by pDCs.
	0.92	IRF8, RUNX2 and CIITA; the cell surface markers BDCA2, ILT7, SIGLEC-H; and the nucleic acid sensors TLR7, TLR9 and PACSIN1 (Figure 2).
30979057	0.94	IRF8 activation as well as expression of TLR3, TLR7 and IFN-beta by DC.
24109483	0.93	TLR-7, IRF5, IRF7, IRF8, IRAK1, and TNFAIP3.
21942329	0.91	IRF-8 expression produced by the combination of 007 and IFN-gamma not only provides an explanation for the increased levels of IFN-alpha and IL-12, but also emphasizes the immunotherapeutic benefit of combining 007, a TLR7/8 agonist, with IFN-gamma for treatment of CTCL patients with limited numbers of dendritic cells.
28492552	0.88	Irf8, Klf4, Irf7 and Tlr7, and the expression of a few granulocytic genes were upregulated with the spontaneous maturation of the c-Kit+CD11b++ APL cells from c-Kit+ CD11b+ or cKit+CD11b-AA4.1++ APL progenitors (Figure 4d).
23977359	0.66	TLR7, TLR9 and IRF-8.
23132256	0.60	IRF8 and IRF9, IRF2 and IRF4 play negative roles in TLR7/9 signaling.