Publication for REG3A and REG4

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
hsa	REG3A	regenerating family member 3 alpha	5068			[link]
hsa	REG4	regenerating family member 4	83998

Pubmed ID	Priority	Text
25767811	0.98	REG III, HIP/PAP, and REG IV) were isolated, their expressions in beta cells under inflammatory conditions remained unclear.
	0.97	REG III, HIP/PAP, nor REG IV transcription as much as IL-6 + Dx did.
	0.93	REG III, HIP/PAP, and REG IV) were isolated.
	0.74	REG III and REG IV was induced to some extent by IL-6 + Dx, the increments were quite small (Figures 1(c) and 1(e)).
	0.59	REG III, HIP/PAP, and REG IV).
28955777	0.98	hepatocarcinoma-intestine-pancreas/pancreatitis-associated protein [HIP/PAP] and REG IV) have been isolated.
	0.98	HIP/PAP (D), and REG IV (E) in HepG2 cells treated by normoxia or IH for 24 h were measured by real-time RT-PCR.
	0.98	REG III, and REG IV) were not increased (Fig. 3).
	0.97	REG III, HIP/PAP and REG IV) and found that HIP/PAP was significantly increased by IH (Fig. 3, Supplementary Fig. 5).
29090282	0.98	HIP/PAP (D), and REG IV (E) was measured by real-time RT-PCR.
	0.97	REG III, HIP/PAP, and REG IV) in CD and UC samples and found that REG family genes (REG Ialpha, REG Ibeta, and REG IV) were overexpressed in CD colons and that the REG IV gene was also overexpressed in UC samples.
	0.97	HIP/PAP , and REG III are tandemly ordered in the 95 kbp region of chromosome 2p12, whereas REG IV locates on chromosome 1.
	0.66	REG III, HIP/PAP, and REG IV) mRNA expression by real-time RT-PCR and found that REG Ialpha, REG Ibeta, and REG IV genes were overexpressed in CD colon samples (Fig. 1A, B, and E).
24759849	0.98	REG IIIalpha and REG IV was not observed in the pancreas of FT1DM (Figure S4).
	0.97	REG IIIalpha and REG IV was not observed in human type 1 diabetes (Figure S4).
	0.81	REG IIIalpha and REG IV, have been reported in the type 1 diabetic condition (insulitis) in rodent models.
19834624	0.98	REG3A and REG3G (Type 3) and REG4 (Type 4).
	0.98	reg3A and reg3G genes, all located on chromosome 2p12, reg4 is on chromosome 1p13.1-p12.
28357125	0.98	Reg-3, 28521-28560; Reg-4, 28791-28814; Reg-5, 29081-29154; Reg-6, 30378-30402; Reg-7, 31261-31271; Reg-8, 31431-31510).
	0.97	Reg-3, Reg-5, and Reg-6 for H3K4me3; Reg-2, Reg-5, and Reg-8 for H4K16ac); a decrease in H3K27me3 was detected in Reg-4 (Fig. 11).
28482337	0.98	RegIIIalpha and RegIV are bactericidal.
	0.98	RegIIIalpha and RegIV bound to glycoconjugate ligands, including purified soluble peptidoglycan (sPG), chitooligosaccharides (beta1-4-GlcNAc polymers), and mannose, indicates that Reg proteins do not use a traditional C-type binding site nor do they require calcium ions for interaction with glycans.
30692510	0.98	REG3, but not REG1 or REG4 (Fig. 6a), and that neither IL-17E nor IL-17B could induce AGS cells to express other antibacterial proteins beta-defensin (BD)-1/2/3/4 (Fig. 6a).
	0.97	REG3, and REG4 in AGS cells stimulated with IL-17E or IL-17B was compared (n = 3).The heatmap was performed by the software HemI.1.0 based on the Quantitative RT-PCR values.
31696115	0.98	REG3A (PDB ID: 4MTH,), and (C) REG4 (PDB ID: 2KV3,).
	0.80	REG3A, REG3G, and REG4.
27788482	0.98	Reg3A, Reg3G and Reg4 have been identified in humans.
28608985	0.98	Reg4) with better identification performance than CK+/CD45- (Reg3) is not supported.
18457593	0.97	Reg4 in the villus epithelium and Reg3A in crypt epithelium highlights that differential expression of this gene family may serve as useful indicators (perhaps even important mediators) of differentiation in human ileal epithelial cell lineages.
	0.85	Reg4 was particularly interesting due to its role in activating the EGF receptor, and its classification, like Paneth cell Reg3A, within the regenerating (Reg) family of genes.
29088818	0.97	REG3A (23 fold increase), REG4 (9 fold increase), and REG1A (4 fold increase), which are known to be involved in cell proliferation and have a key role in carcinogenesis by activating the AKT and ERK1/2 pathways.
29124146	0.97	REG III, HIP/PAP, and REG IV) have been isolated.
29222406	0.97	REG3A and REG4.
31767869	0.97	REG3A) and REG protein 1 gamma (REG3G) all clustered closely on chromosome 2p12 along with REG protein 4 (REG4) situated on chromosome 1p12.
21992413	0.96	REGIII, and REGIV.
22582090	0.96	REG4 appears to be homologous to both PAP/HIP/p23 and PSP/lithostathine/REG1 but was originally classified in a separate subfamily (type 4).
22943287	0.96	Reg-III (corresponding to Reg-IIIalpha in the mouse), HIP/PAP (corresponding to Reg-IIIbeta in the mouse), Reg-IIIgamma and Reg-IV have been identified.
27539087	0.96	PAP and REG IV, with an association between REG-I expression and islet cell replication.
26646797	0.93	REG3A and REG4, have been found to be up-regulated in human CRC tissues.
29512686	0.91	REG3A belongs to REG protein family, which includes REG1, REG3A and REG4.
24151146	0.90	Reg3alpha, Reg3beta and regenerating gene 4 (Reg4).
19900450	0.88	Reg IIIalpha, Reg IIIbeta and Reg IV.
31921694	0.85	Reg3A), a 19 kD secreted calcium-dependent lectin protein, belongs to the Reg (Regenerating) family which includes four subclass (Reg1A, Reg1B, Reg3A, and Reg4) in humans based on the primary structures of DNA sequence and protein.
28435292	0.78	REG3A, and REG4 have been found to be upregulated in GC.
26077911	0.68	REG3 (III and HIP/PAP); and REG4.
26981633	0.60	REG3 and REG4 have been associated with inflammation, diabetes and cancers.
31139647	0.53	HIP/PAP, REG III, and REG IV.