Publication for REG3A and REG1A

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
hsa	REG3A	regenerating family member 3 alpha	5068			[link]
hsa	REG1A	regenerating family member 1 alpha	5967

Pubmed ID	Priority	Text
23519454	0.98	REG1A, REG1B, REG3A and REG4 all show increased expression during inflammatory bowel disease (IBD)-related inflammation of the colon (Dieckgraefe et al.; Granlund et al.; Lawrance et al.).
	0.97	REG1A, REG1B, REG3A and REG4, are closely related in genomic sequence and all are part of the c-type lectin superfamily.
	0.97	REG1A, REG1B and REG3A with their expression focused in the crypt base spreading from Paneth cells and REG4 being more highly expressed towards the luminal face.
	0.97	REG1A, REG1B and REG3.
	0.97	REG1A, REG1B, REG3A and REG4.
	0.97	REG1A, REG1B, REG3A and REG4.
	0.96	REG gene family currently consists in four well-established members: REG1A, REG1B, REG3A and REG4.
	0.96	REG1A (a/d), REG3A (b/e) and REG4 (c/f).
	0.95	REG1A, REG3A and REG4 are the best studied.
	0.95	REG1A, REG1B, REG3A and REG4 in IBD samples are given in Fig. 2.
	0.95	REG1A/REG1B/REG3A in healthy small intestine could also be explained by such a mode of induction, as Paneth cells are present in healthy small bowel (Parikh et al.).
	0.94	REG1A, REG1B and REG3A expression expanded upwards from the crypt base, whereas REG4 expression was higher towards the luminal end of the crypts, often with no expression in the lower third.
	0.91	REG1A, REG1B and REG3A mRNA.
	0.87	REG1A, REG1B and REG3A) and enteroendocrine cells (REG4), with a marked expansion of expression during inflammation.
	0.87	REG1A, REG3A and REG4 was similar to that seen in the IBD samples (results not shown).
	0.86	REG1A, REG1B and REG3 show an apparently Paneth-cell-dependent expansion from the colonic crypts during inflammation, whereas REG4 is expressed in serotonin-producing enteroendocrine cells and expands to epithelial cells of the upper colonic crypts during inflammation.
	0.76	REG3A mRNA expression during inflammation, seemed limited compared with that for REG1A, rarely stretching much beyond the bottom third of the crypts.
	0.60	REG1A and REG1B, seen together with sequence similarities with REG3A, suggests that these peptides are good candidates for the screening of antimicrobial effects.
24604486	0.98	PSP/PAP levels correlate with postoperative infectious complications and general postoperative complications as graded by the validated Clavien-Dindo classification for postoperative surgical complications.
	0.97	PSP/PAP will be acquired.
	0.97	PAP and PSP are secreted in other organs, such as the small intestine.
	0.97	PSP/PAP can be used as a predictive marker for postoperative infectious complications and sepsis.
	0.95	PAP and PSP/reg may provide valuable information and aid in differentiating between both events in the postoperative setting.
	0.94	PSP/PAP as a sepsis marker in an independent, prospective patient cohort.
	0.94	PSP/PAP expression values to current markers of inflammation in patients undergoing major abdominal surgery.
	0.93	pancreatitis-associated protein (PSP/PAP) in an abdominal surgical study population.
	0.93	PAP and PSP/reg as postoperative inflammatory serum markers in patients having major abdominal surgery, although it has been demonstrated that PSP/PAP play an important role in various inflammatory events models.
	0.92	Pancreatic stone protein (PSP) and pancreatitis-associated protein (PAP): a protocol of a cohort study on the diagnostic efficacy and prognostic value of PSP and PAP as postoperative markers of septic complications in patients undergoing abdominal surgery (PSP study)
	0.92	PSP/PAP levels at time of admission to intensive care unit (ICU) to predict infection/sepsis outcome during postoperative course including total ICU days and total length of stay.
	0.91	pancreatitis-associated protein (PAP) and the pancreatic stone protein/regenerating protein (PSP/reg), known as secretory stress proteins (SSPs).
	0.81	PSP trial is a prospective monocentric cohort study evaluating the prognostic value of PSP and PAP for postoperative infectious complications.
	0.67	PAP and PSP play an important role in various inflammatory events, not only in pancreatitis but also in sepsis subsequent to other inflammatory diseases.
	0.56	PAP, pancreatitis-associated protein; PSP, pancreatic stone protein.
	0.52	PAP and PSP/reg attained from venous samples of patients undergoing major abdominal surgery.
25767811	0.98	REG III, (d) HIP/PAP, and (e) REG IV in rat RINm5F cells.
	0.98	REG Ialpha, (b) REG Ibeta, (c) REG III, (d) HIP/PAP, and (e) REG IV in human 1.1B4 cells treated without (no addition) or with Dx (100 nM), or IL-6 (20 ng/mL), or IL-6 + Dx. Data are represented as the ratio of the number of target mRNA copies to the number of beta-actin mRNA copies and expressed as means +- SE for each group (N = 4).
	0.93	REG family genes (REG Ialpha, REG Ibeta, REG III, HIP/PAP, and REG IV) were isolated.
	0.92	REG Ialpha, (b) REG Ibeta, (c) REG III, (d) HIP/PAP, and (e) REG IV in human 1.1B4 beta cells.
	0.91	PAP significantly; however, the fold increases were much smaller compared to that of REG Ialpha (Figures 1(a), 1(b), and 1(d)).
	0.61	REG family genes (REG Ialpha, REG Ibeta, REG III, HIP/PAP, and REG IV) were isolated, their expressions in beta cells under inflammatory conditions remained unclear.
	0.54	REG Ialpha, REG Ibeta, REG III, HIP/PAP, nor REG IV transcription as much as IL-6 + Dx did.
	0.51	REG genes (REG Ialpha, REG Ibeta, REG III, HIP/PAP, and REG IV).
27788482	0.98	Reg1A and Reg3A/G (pancreatitis-associated proteins) were associated with ADM (A) Increased Reg1A and Reg3A/G protein expressions in acinar cells undergoing ADM, compared to normal tissues
	0.97	Reg1A and Reg3A/G were highly expressed in the ADM tissues by immunohistochemistry.
	0.97	Reg1A and Reg3A/G. Arrows: duct-like structure in tumor adjacent acini B. Co-localization of Reg1A and CK19 in cancer epithelium and duct-like structures.
	0.96	Reg1A, Reg1B and Reg3A proteins in PDAC, in comparison to normal subjects and patients with pancreatitis.
	0.95	Reg1A or Reg3A/G was observed in normal acini and ducts (Figure 1A).
	0.94	Reg1A and Reg3A/G positive duct-like structures were observed in tumor-adjacent acinar areas (Figure 1A).
	0.85	Reg1A and Reg3A/G were involved in acinar-to-ductal metaplasia
	0.70	Reg1A and Reg3A/G expressions in ADM tissues were demonstrated by immunohistochemistry.
28955777	0.98	REG Ialpha or HIP/PAP into HepG2 cells, cells were exposed to normoxia or IH conditions for 24 h, and cellular proliferation was measured by WST-8 assay.
	0.97	HIP/PAP is considered to be a member of the REG family gene.
	0.95	REG family genes (REG Ialpha, REG Ibeta, REG III, HIP/PAP and REG IV) and found that HIP/PAP was significantly increased by IH (Fig. 3, Supplementary Fig. 5).
	0.94	REG family members (REG Ialpha, REG Ibeta, REG III, and REG IV) were not increased (Fig. 3).
	0.93	HIP/PAP inhibited HepG2 cell proliferation measured by WST-8 assay, whereas interference of REG Ialpha did not (Fig. 5).
	0.92	REG Ialpha (A), REG Ibeta (B), REG III (C), HIP/PAP (D), and REG IV (E) in HepG2 cells treated by normoxia or IH for 24 h were measured by real-time RT-PCR.
	0.89	Reg family genes (REG Ialpha, REG Ibeta, REG III, hepatocarcinoma-intestine-pancreas/pancreatitis-associated protein [HIP/PAP] and REG IV) have been isolated.
	0.69	hepatocarcinoma-intestine-pancreas/pancreatitis-associated protein (HIP/PAP) : one of REG (Regenerating gene) family.
27846243	0.98	REG1A is associated with poor prognosis in CRC, and recurrence and/or distant metastasis and short median survival in patients with MSI+ tumours; it is noteworthy therefore that the upregulation of REG1A and REG3A seen here is specific to Fusobacterium-high tumours, rather than MSI+ tumours, with these genes being not significantly differentially expressed in MSI+ vs. MSI- tumours in our cohort.
	0.97	REG3A, REG1A and REG1P in the case of high-level colonization by Fusobacterium, and CXCL10 and BMI1 in the case of colonisation by E. faecalis.
	0.87	REG1A, REG1B and REG3A are all expressed at the intestinal crypt base by metastatic Paneth cells; REG1A and REG1B have also been reported to be concomitantly upregulated in CRC, but no mechanistic rationale has been provided previously.
	0.59	REG1A, REG3A and REG1P, as well as a borderline significant expression for REG1B (FC = 12.2, FDR = 0.17).
31767869	0.98	REG family protein-coding genes in humans, REG protein 1 alpha (REG1A), REG protein 1 beta (REG1B), REG protein 3 alpha (REG3A) and REG protein 1 gamma (REG3G) all clustered closely on chromosome 2p12 along with REG protein 4 (REG4) situated on chromosome 1p12.
	0.98	REG3A genes on the opposite strand to REG1A that was previously thought to be a pseudogene has recently been annotated to represent a long noncoding RNA (lncRNA) termed REG family member 1 gamma pseudogene (REG1CP; HUGO Gene Nomenclature Committee: 9953).
	0.95	REG3A genes on the opposite strand to REG1A on chromosome 2.p12 (Supplementary Fig. 1A, B).
	0.94	REG3A promoter, but not to REG1A or REG1B promoter (g).
28415799	0.97	PSP is expressed in the duodenum, primarily in PANETH-like cells, PAP isoforms I & III localize mainly to enterocytes.
	0.97	PSP & PAP respond to remote lesions?
	0.96	PAP refers to the left y-axis, PSP to the right x-axis.
	0.96	PSP and PAP respond to remote injury we started a pilot experiment by inflicting a small lesion in the distal duodenum, followed by sampling immediately, 6, 12, and 24 hours later.
	0.96	PSP and PAP synthesis.
	0.96	PSP and PAP?
	0.95	PSP and PAP was quantified by isoform specific ELISA, expressed as ng/mg total protein.
	0.95	PSP and PAP isoforms were quantified immediately, 6, 12, and 24 hrs the operation.
	0.95	PSP and PAP in the duodenum is much lower, only moderate changes could be observed (Figure 5) for both proteins.
	0.94	PSP and PAP contents are expressed as ng/mg tissue protein.
	0.94	PSP and PAP isoforms in humans, rats, and mice.
	0.92	PSP and PAP strongly increased - at all sampled sites - with a peak at twelve hours, indicating that the synthesis of these proteins responds to damage in the vicinity.
	0.92	PSP appeared much stronger in the vicinity of the lesion and also PAP I demonstrated a strong upregulation (Figure 3M, 3N, 3P).
	0.92	PSP and PAP has not been available until now and, although merely descriptive, these data might give reference for future studies to evaluate potential sources of these proteins under physiological and pathological conditions.
	0.90	PSP and PAP in intestinal organs support these determinations despite visible degradation, particularly in the pancreas (Supplementary Figure 4).
	0.89	PSP was also named pancreatic thread protein, lithostatin and regenerating protein I, while PAP was renamed regenerating protein III.
	0.86	PSP, PAP, and major cytokines (TNFa and IL-6) or the chemokine MCP-1 (Supplementary Figure 2).
	0.85	PSP and PAP in human tissue mirrored the distribution in the murine models.
	0.85	PSP and PAP was visualized by immunohistochemistry.
	0.85	Pancreatic Stone Protein (PSP/regI) and Pancreatitis-Associated Protein (PAP/regIII) have been identified several decades ago.
	0.85	PSP and PAP were demonstrated to promote bacterial aggregation.
	0.83	PSP and PAP in another organ.
	0.82	PSP and PAP seem to react preferentially to local damage and less to remote injury.
	0.81	PSP demonstrated a 100-fold higher content in the pancreas compared to any other organ while PAP was most abundant in the small intestine.
	0.77	PSP, PAP expression in the pancreas responded more pronounced when treated with the full CLP procedure, while the sham operation caused an intermediate increase.
	0.71	PSP is several magnitudes higher in the pancreas than any other organ while PAP is predominantly expressed in the small intestine.
	0.65	PSP (A) and PAP (B) in human autopsy cases after unnatural death.
	0.65	PSP is from the pancreas while PAP is mainly produced by the intestine.
	0.56	PSP and PAP in animal models of sepsis and in healthy humans.
	0.54	PSP and PAP, which organs are responsive to infected or septic conditions, and how can we explain the appearance of PSP in blood under both, healthy and pathological conditions.
	0.51	PSP & PAP expression in the intestine (Figure 4).
	0.50	PSP and PAP.
29090282	0.97	REG family genes (i.e., REG Ialpha, REG Ibeta, REG-related sequence (pseudogene), HIP/PAP (INGAP), and REG III) are tandemly ordered in the 95 kbp region of chromosome 2p12, whereas REG IV is located on chromosome 1q12-q21.
	0.97	REG family (REG Ialpha, REG Ibeta, REG III, HIP/PAP, and REG IV) mRNA expression by real-time RT-PCR and found that REG Ialpha, REG Ibeta, and REG IV genes were overexpressed in CD colon samples (Fig. 1A, B, and E).
	0.97	REG family genes (REG Ialpha, REG Ibeta, and HIP/PAP) were highly expressed in IBD colonic mucosa.
	0.97	REG family mRNAs (REG Ialpha, REG Ibeta, REG III, HIP/PAP, and REG IV) in CD and UC samples and found that REG family genes (REG Ialpha, REG Ibeta, and REG IV) were overexpressed in CD colons and that the REG IV gene was also overexpressed in UC samples.
	0.95	REG family genes, i.e., REG Ialpha , REG Ibeta , REG-related sequence (pseudogene) (RS), HIP/PAP , and REG III are tandemly ordered in the 95 kbp region of chromosome 2p12, whereas REG IV locates on chromosome 1.
	0.94	REG genes (REG III and HIP/PAP) was not changed in IBD colon samples (Fig. 1C and D).
	0.93	REG family genes (REG Ialpha, REG Ibeta, REG III, HIP/PAP, and REG IV) in biopsy specimens of UC and CD by real-time RT-PCR.
	0.72	REG Ialpha (A), REG Ibeta (B), REG III (C), HIP/PAP (D), and REG IV (E) was measured by real-time RT-PCR.
	0.71	REG Ialpha and REG Ibeta mRNA in resected colonic tissue from CD and UC was first reported by Lawrance et al.. We also showed the overexpression of HIP/PAP and REG III in IBD.
19254208	0.97	PAP and PSP were shown to induce bacterial aggregation without inhibiting growth, and trypsin appeared to stimulate the effect of PSP.
	0.97	PAP and PSP have been known to undergo tryptic cleavage and consequent insoluble fibril formation, however, the significance of the proteolytic processing in the antibacterial activity of PAP has not been studied.
	0.96	PSP, suggesting that PAP function might be similarly regulated by trypsin.
	0.82	PAP and PSP result in the formation of insoluble fibrils, which were suggested to be responsible for the biological activity of these lectin-like proteins [, PSP reviewed in ].
	0.66	PAP is not bactericidal is also in agreement with earlier reports indicating that PAP or PSP had no inhibitory effect on bacterial growth.
22943287	0.97	Reg family proteins have been identified and described under various nomenclatures such as pancreatitis-associated protein (PAP) and hepatocarcinoma-intestine-pancreas (HIP).
	0.95	Reg-Ialpha, Reg-Ibeta, Reg-III (corresponding to Reg-IIIalpha in the mouse), HIP/PAP (corresponding to Reg-IIIbeta in the mouse), Reg-IIIgamma and Reg-IV have been identified.
	0.92	Reg-I could be a marker for BCa, the ELISA used in this study showed virtually no cross-reactivates with Reg-Ialpha and -Ibeta proteins (Figure2), indicating that the urinary signal detected in the ELISA was HIP/PAP and not Reg-I. In this study, we investigated six cases of non-interstitial severe cystitis patients in the group of benign urological disease, and two in the six cases were false positive.
24328148	0.96	REG1A, (B) REG1B, (C) REG3A, (D) Phospholipase A2 (PLA2), and (E) Pancreatic lipase-related protein 2 (LIPR2).
	0.94	REG protein family have been linked to gastric, liver, and pancreatic cancer and we detected increased REG1a, REG1b, and REG3a proteins in ductal fluid from cancer patients.
	0.93	REG1A, REG1B, and REG3A) and one protein that was consistently decreased (LIPR2).
	0.85	REG1a, REG1b, and REG3a, as well as increased heterogeneity of REG proteins as candidate biomarkers requiring further validation.
24091659	0.96	PAP-1 and PSP were substantially increased by LPS treatment and treatment and were further increased by alcohol exposure, although this did not reach statistical significance.
	0.91	pancreatitis-associated protein-1 (PAP-1) and pancreatic stone protein (PSP) increased ~400-fold and 130-fold, respectively, in pair-fed and alcohol-fed animals 24 h after LPS, indicating the early induction of pancreatitis-associated acute-phase proteins (Supplementary Figures 2a and b).
31696115	0.96	Reg family comprises four groups (Reg1, Reg2, Reg3, and Reg4) of proteins based on their primary structure.
	0.65	REG1A compared to healthy subjects, and REG3A is also increased in ductal fluid.
31921694	0.96	Regenerating islet-derived protein 3A (Reg3A), a protein mainly expressed in the digestive system, has been found over-expressed in many kinds of gastrointestinal cancer, including hepatocellular carcinoma, pancreatic cancer, gastric cancer, and colorectal cancer, therefore has been considered as a promising tumor marker.
	0.96	Regenerating islet-derived protein 3A (Reg3A), a 19 kD secreted calcium-dependent lectin protein, belongs to the Reg (Regenerating) family which includes four subclass (Reg1A, Reg1B, Reg3A, and Reg4) in humans based on the primary structures of DNA sequence and protein.
27167163	0.95	REG proteins encoded by REG1A, REG1B, REG3A, REG3G), but are also expressed in the CNS and related to neurodevelopment in the fetal brain and neuronal sprouting and synaptogenesis in the adult brain.
28945764	0.95	REG proteins have several activities that function to control intestinal microbiota, and since intestinal dysbiosis is in part responsible for the development of GVHD, our findings lead to the novel concept that REG3A could have some protective effect in the pathogenesis of GVHD through the regulation of gut microbiota.
31541294	0.93	REG1A and the other members of the REG1 family (REG1B, RS (REG-related sequence), and PAP genes) are clustered in a 95-kb region on chromosome 2p12.
31940813	0.93	REG1A and REG3A in human primary liver tumor with beta-catenin mutations.
22608059	0.91	Reg1alpha and Reg3alpha proteins are indicated on the left side of the figure.
	0.86	REG1A and REG3A secreted proteins
	0.85	REG1A and REG3A) were among the most highly upregulated in a subset of 7 patients.
	0.77	Reg1alpha and Reg3alpha are both secreted growth factors associated with pancreatic islet cell regeneration, which were previously linked to a number of gastrointestinal cancers, including hepatocellular carcinoma.
	0.75	Reg1alpha and Reg3alpha have not been associated with HCV or HIV infection or pathogenesis.
	0.65	Reg1alpha and Reg3alpha levels in patient plasma specimens by immunoblot (Figure 3), we observed that HCV/HIV patients exhibited substantially higher levels of circulating Reg1alpha species compared to monoinfected individuals.
19900450	0.89	Reg gene family include Reg Ialpha, Reg Ibeta, Reg IIIalpha, Reg IIIbeta and Reg IV.
20835340	0.88	Reg family have been discovered: Reg1alpha, Reg1beta, HIP/PAP, and the homologue of islet neogenesis-associated protein (IN-GAP).
29124146	0.87	REG family genes (REG Ialpha, REG Ibeta, REG III, HIP/PAP, and REG IV) have been isolated.
	0.70	REG 3gamma (HIP/PAP) expression in gastric epithelial cells.
24065141	0.84	REG Ialpha and REG Ibeta genes on lung cancer cell lines, and thereafter, the expression of REG family genes (REG Ialpha, REG Ibeta, REG III, HIP/PAP and REG IV) in lung cancer in relation to patient prognosis was evaluated.
	0.66	REG family found in humans (REG Ialpha, REG Ibeta, REG III, HIP/PAP and REG IV), encoding a growth factor family of proteins involved not only in regeneration of damaged tissues but also in the growth of various types of cancers, including gastrointestinal cancer, cholangiocarcinoma, pancreatic cancer, breast cancer and prostate cancer.
20644627	0.83	Reg 1 alpha, Reg 1 beta, Reg 3 alpha, and Reg 3 gamma.
31780871	0.82	HIP/PAP (type III REG) expression in Caco2 and HCT116 cells were examined by Western blot analysis.
	0.82	REG Ialpha and Ibeta and HIP/PAP in pancreatic or colon cancer cells, although it remained unclear whether STAT3 and/or other transcriptional factors actually bind to these elements.
25688244	0.82	RegIIIalpha is a member of a large family of Reg genes but is one of only two RegIII genes found in humans.
27092078	0.79	INGAP is a member of the Reg protein family, which can induce beta cell neogenesis and proliferation (Tam et al.,).
29512686	0.75	REG3A belongs to REG protein family, which includes REG1, REG3A and REG4.
18547137	0.72	REG1A, REG3, WFDC2 (whey-acidic protein [WAP] four-disulfide core domain 2), and IGFBP4 were obtained by ELISA.
	0.59	REG1A, REG3, and IGFBP4) was chosen on the basis of up-regulation at the PanIN stage.
31557884	0.69	HIP/PAP, a Reg family member, was reported to be a hepatocyte mitogen and the small interfering RNA for HIP/PAP attenuated the IH-induced hepatocyte proliferation.
22582090	0.68	REG1alpha and REG3alpha.
	0.51	REG1alpha and REG3alpha correlating with beta-catenin mutations.
29662668	0.66	REG-1-Alpha, REG-1-Beta, and REG-3-Alpha, and lower concentrations of pancreatic lipase-related protein (LIPRP) 2 were observed in samples from patients with cancer than in those from healthy individuals.
18457593	0.60	Reg3A, within the regenerating (Reg) family of genes.