Publication for DEFA5 and REG3A

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
hsa	DEFA5	defensin alpha 5	1670			[link]
hsa	REG3A	regenerating family member 3 alpha	5068

Pubmed ID	Priority	Text
30542108	0.98	DEFA5 & DEFA6) and REG3A were not included in the core iCD list (Fig. 1A), as these were only suppressed in older iCD compared to both younger iCD and Ctl (Fig. 1C).
29040430	0.97	DEFA5, IL33, and REG3A showed also increased expression levels in control male samples when compared with control female samples.
	0.96	REG3A, DEFA5, and IL33 might be considered as colorectal cancer [CRC] risk factors following UC in males.
	0.96	defensin alpha 5 [DEFA5], serine protease 8 [PRSS8], mucin 5B [MUC5B], phospholipase A2 group IIA [PLA2G2A], Fc fragment of IgG binding protein [FCGBP], regenerating family member 3 alpha [REG3A], interleukin 33 [IL33], and interferon alpha inducible protein 27 [IFI27].
	0.96	REG3A], defensin A5 [DEFA5], and interleukin 33 [IL33] [Figure 4].
18457593	0.97	HD5, Reg3A is known as a downstream Wnt/beta-catenin signaling target.
	0.92	Reg3A transcription also displayed a markedly similar tissue specific expression profile to HD5 (Figure 5B), apparently transcribed along the alimentary tract exclusively within the small bowel.
	0.57	HD5, Reg3A, aldolase-B, Eps8L2, Muc3beta, semaphorin3F, RETLNB, ApoA4, Eph-Rb3 and Pdxp.
25991924	0.97	REG3A, DEFA5 and DEFA6 have been shown previously to be significantly up-regulated and linked to Paneth cell metaplasia in IBD.
	0.96	REG3A (Regenerating islet-derived 3 alpha), DEFA5 (Defensin, alpha 5, Paneth cell-specific) and DEFA6 (Defensin, alpha 6, Paneth cell-specific), were >30-fold up-regulated specially in iCD versus control.
31242501	0.97	Reg3alpha, LYZ/Lyz 1, DEFA5/Defa, MUC2, TFF3, CDH1, OCLN1, MK167, CHGA, DCLK1, and LGR5 (A), and a second Principle Coordinate Analysis was generated using the maximum relative values fromREG3gamma/Reg3alpha, LYZ/Lyz 1, DEFA5/Defbeta, MUC2, TFF3, andCHGA(B) to determine relative similarities between developmental stages.
	0.95	Reg3alpha, LYZ/Lyz 1, and DEFA5/Defa (center plot), and MUC2, and TFF3 (right plot).
28934349	0.96	Reg3alpha (p<=0.001), HD5 (p<=0.002) and HD6 (p<=0.02).
	0.95	HD5, HD6 and Reg3alpha was higher in the small intestine (n = 22) than in the stomach (n = 8) and large intestine (n = 104) in histologically normal biopsies (n = 134, p<0.02, Mann-Whitney-U-Test).
	0.92	HD5, HD6, and Reg3alpha in the presence of severe acute GI GvHD, although to a much lower extent than seen in the upper GI biopsies.
	0.70	HD5 (p = 0.004), HD6 (p = 0.006) and Reg3alpha (p = 0.012) was significantly decreased (Mann-Whitney-U-Test) in case of severe acute GvHD (stage 2-4) (3A).
19956723	0.95	DEFA5, DEFA6, DEFB4, LYZ, PI3, S100A7, S100A8, S100A9, S100A12, PF4, PPBP, CSTA, ADM, C1R, C1QA, PLA2G2A, LTF, LCN2, REG3A, NOS2A and ZC3HAV1) was more than 2-fold significantly increased before treatment in active IBDc as compared with control colons.
26801768	0.94	DEFA5, DEFA6, REG3A, LCN2, TFF3, HBA2 and HBG2.
	0.78	DEFA5, REG3A, LCN2 and TFF3 and down-regulation of HBA2 and HBG2 expression in NEC.
26050928	0.84	DEFA5 and REG3A, similar to fetal tissue (Figures 1F and 4A).