Publication for REG3A and REG3G

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
hsa	REG3A	regenerating family member 3 alpha	5068			[link]
hsa	REG3G	regenerating family member 3 gamma	130120

Pubmed ID	Priority	Text
26658437	0.97	HIP/PAP and presumably RegIIIgamma, a required step for their membrane insertion into Gram-positive target cells.
	0.94	HIP/PAP and RegIIIgamma undergo robust mRNA and protein induction under the direction of IL-17, another cytokine capable of eliciting Stat3 phosphorylation.
	0.94	RegIIIgamma and HIP/PAP promote keratinocyte proliferation and prevent terminal differentiation in states of wound repair and psoriasis.
	0.90	HIP/PAP and RegIIIgamma Antimicrobial Peptides during Mammalian Urinary Tract Infection
	0.90	RegIIIgamma and HIP/PAP are markers of urothelial injury
	0.90	RegIIIgamma or HIP/PAP exhibit direct microbicidal activity, it remains conceivable that they may work cooperatively with other AMPs or host immune cells to serve an antimicrobial function in certain Gram-negative infections.
	0.73	RegIIIgamma and HIP/PAP as markers of urothelial injury.
19095652	0.97	RegIIIgamma and rpro-HIP/PAP following mock digestion for 2 h at 37 C (Fig. 2, A and B).
	0.94	RegIIIgamma and HIP/PAP bind to bacterial surfaces through specific recognition of peptidoglycan, and that this binding interaction is not modulated by the prosegment.
	0.90	HIP/PAP (hepatointestinal pancreatic/pancreatitis-associated protein; the human ortholog of RegIIIgamma)6 is expressed in the human intestine and is up-regulated in patients with inflammatory bowel disease.
	0.90	RegIIIgamma and HIP/PAP in small intestinal tissue extracts, we cannot completely rule out the possibility of some intracellular cleavage.
	0.89	RegIII family members (Fig. 1B), and is also present in other Reg subfamilies including RegI. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) of both RegIIIgamma forms did not reveal any further modifications of the protein (data not shown).
32240190	0.97	REG3beta and REG3gamma (Fig 4b) were not increased due to ACET treatment, however, were significantly increased due to BUT (2.5-fold and 3-fold, respectively) compared to CON.
	0.90	Reg3beta) and 3gamma (Reg3gamma; Fig 2b) were increased moderately due to ACET treatment (20-fold and 40-fold), but were much more significantly increased due to BUT (150-fold and 350-fold, respectively) and PROP (250-fold, and 480-fold, respectively, P < 0.05) compared to CON.
	0.72	Reg3beta, Reg3gamma, and Defb1 were stimulated by BUT and PROP, but not by ACET which had a greater effect on expression of tight junction genes Cldn3 and Ocln in 3D enteroids.
19834624	0.97	reg3A and reg3G genes, all located on chromosome 2p12, reg4 is on chromosome 1p13.1-p12.
31221081	0.97	REG3A, REG3G, FZD1 and SH3BP4), out of six with human orthologs, showed 35 significantly enriched BP, predominantly related to epithelial, inflammatory, nitrogen compound, and cell proliferation and differentiation processes (see Additional file 11: Figure S10).
25349560	0.96	HIP/PAP and REG3gamma are mainly produced in Paneth cells and endocrine cells around the intestinal epithelial cells of the gut and ascending colon in adults.
20644627	0.94	Reg 3 alpha and Reg 3 gamma since the expression was not detectable in two control samples each).
	0.92	REG3A, and REG3G was quantified by real-time PCR, performed on samples from four T2D subjects and four controls, which, confirmed the differential expression between the two groups (Fig. 3 A-D).
	0.90	Reg 3 alpha, and Reg 3 gamma.
21694778	0.94	HIP/PAP (hepatointestinal pancreatic/pancreatitis associated protein), a human ortholog of RegIIIgamma interacts with the carbohydrate moiety of peptidoglycan which may be also the case for RegIIIbeta.
31726747	0.93	Reg3beta and Reg3gamma in the mucosa of the small intestine, which may contribute to the changes in intestinal microbiome.
18795106	0.92	Reg3g, Reg3a, Regl), several well-known endocrine transcripts (Pcsk1 (PC1/3), Iapp, Slc30a8), secretogranins (Scgb2a1, Scgn, Scg5, Scg2, Scg3), and transcription factors known to function in the islet (FoxA2, Nkx2.2, Isl1).
31242501	0.90	REG3gamma/Reg3alpha, LYZ/Lyz 1, and DEFA5/Defa (center plot), and MUC2, and TFF3 (right plot).
	0.89	REG3gamma/Reg3alpha, LYZ/Lyz 1, DEFA5/Defa, MUC2, TFF3, CDH1, OCLN1, MK167, CHGA, DCLK1, and LGR5 (A), and a second Principle Coordinate Analysis was generated using the maximum relative values fromREG3gamma/Reg3alpha, LYZ/Lyz 1, DEFA5/Defbeta, MUC2, TFF3, andCHGA(B) to determine relative similarities between developmental stages.
27539087	0.90	REG III, HIP/PAP and REG IV, with an association between REG-I expression and islet cell replication.
28880262	0.90	REG3A, modulates pancreatic tumor growth via alteration of the TME composition in vivo, we established Reg3g-conditioned Panc02 cells, which exhibited upregulated Reg3g (Supplementary Figure S1a), and then implanted them into mice.
26699651	0.89	REG3A and REG3G, genes that were also upregulated with age in our study.
28944823	0.81	REG3A and REG3G which are involved in STAT3-dependent transcription in UC.
27788482	0.80	Reg3 subfamily, including Reg3A and Reg3G, are known as pancreatitis-associated proteins due to their activation in response to inflammatory stimuli.
31311100	0.74	REG3alpha and REG3gamma, IL-22-driven expression of these genes was boosted by ERK1/2 inhibition in the LS174T cells (Figure 7C,D) and primary mIECs (Supplementary Figure S4A,B).
23853103	0.71	Reg3 gamma peptide, islet neogenesis associated protein, demonstrated a 27% rise in arginine stimulated C-peptide area under the curve among 63 type 1 patients, with an average of 20 years of type 1 diabetes with no prior detectable fasting C-peptide levels (p = 0.0057).
31696115	0.68	REG3A (also reported as hepatocarcinoma-intestine-pancreatic protein (HIP), pancreatitis-associated protein (PAP), and PAP1) and REG3G (also referred to as PAP1B) are expressed in human cells.
	0.66	REG3A, REG3G, and REG4.
27830702	0.65	REG3A and RegIIIgamma markedly induced SHP-1 in a time-dependent manner in human keratinocytes or mouse skin (Fig. 4a-c, Supplementary Fig. 5a-c).
22727489	0.55	REG3A or RegIIIgamma is Abundantly Expressed in Epidermal Keratinocytes of Psoriasis Patients and Imiquimod-Induced Psoriatic Skin Lesions