Publication for NFKBIA and SOD2

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
hsa	NFKBIA	NFKB inhibitor alpha	4792			[link]
hsa	SOD2	superoxide dismutase 2	6648

Pubmed ID	Priority	Text
24047462	0.97	IkappaBalpha degradation and the upregulation of MnSOD expression, HeLa cells were infected with lentivirus containing IkappaBalpha mutant (Ser32, 36Ala) prepared in our laboratory.
	0.96	IkappaBalpha and MnSOD expression in the BTG2-dependent manner.
	0.96	MnSOD level (Figure 3A), whereas IkappaBalpha was further accumulated (Figure 3B).
	0.95	MnSOD expression by BTG2, suggesting the upregulation of MnSOD expression by BTG2 via proteasomal degradation of IkappaBalpha.
	0.94	MnSOD expression was reduced by coinfection with IkappaBalpha-mutant which was unable to be disrupted (Figure 3E), supporting the activation of NFkappaB by BTG2 is specific and mediated via IkappaBalpha degradation.
	0.92	MnSOD by accelerating IkappaBalpha degradation in normal and cancer cells
	0.89	MnSOD induction by BTG2 expression, IkappaBalpha degradation was examined by immunoblot analysis.
	0.89	IkappaBalpha after transcfection of BTG2 for 48 h. (C) ChIP assay revealing the interaction of p65 with kappaB-RE in the MnSOD gene in the BTG2 overexpressed cells.
	0.87	IkappaBalpha degradation on the BTG2-regulated MnSOD induction, successive transductions of the lentivirus with nondegradable IkappaBalpha mutant and the Ad-BTG2-HA were performed.
	0.82	MnSOD by transfection of BTG2 (Figure 5A) with concomitant degradation of IkappaBalpha (Figure 5B).
	0.65	MnSOD expression might be one of the intracellular cooperation between APRO gene and a tumor suppressor through the regulations of cell division cycle and intracellular ROS level, since the notion was supported by luciferase assays using promoter and enhancer element of MnSOD gene and by reverse correlations of IkappaBalpha and MnSOD expression, in addition to ChIP and immunoblot analyses (Figure 2).
	0.56	IkappaBalpha protein along with MnSOD expression (Figure 2C).
26583757	0.96	IkappaBalpha, SOD2, and COX2.
	0.93	IKBA, (B) SOD2, and (C) COX2 transcripts.
26435321	0.96	NFKBIA, NFE2L2, SOD2, CAT and LIG3 mRNA levels were increased (Fig. 5b-g).
20649549	0.94	IkappaBalpha inhibits MnSOD expression and decreases the expression of MnSOD-responsive genes, resulting in increased radiation sensitivity in MCF+FIR cells.
32153849	0.94	IkappaBalpha response or the concomitant changes in HSP (CRYAB and HSPB1) and endogenous antioxidant (SOD2 and GPx1) mRNA levels in response to a session of heavy-load strength exercise.
22471522	0.93	MnSOD up-regulation, Ad-IkappaBalpha-DN was used, which effectively inhibited IL-6- and IR-induced NF-kappaB activation (Supplementary Figure S4C) with a corresponding increase in IkappaBalpha protein expression (Supplementary Figure S4D).
	0.78	MnSOD activity at 24 h after treatment with IL-6 (50 ng/ml) and/or IR (C) following pre-treatment with NBD (50 muM for 2 h) or (D) Ad-IkappaBalpha-DN (MOI=10).
17222336	0.93	SOD2, TNFAIP3, IkappaB-alpha and ICAM1, showed an identical expression profile between THP-1 cells, U937 cells and PBMC derived macrophages from both donors (Table 4).
31616422	0.93	nfkbia-2 and -3, sod2, and gpr84 in the head kidney and/or liver.
21945096	0.90	IkappaBalpha gene to inhibit inducible phosphorylation of serine residues 32 and 36 thus preventing subsequent ligand-induced degradation required for NFkappaB activation, completely inhibits induction of SOD2.
25522271	0.89	IkappaBalpha and MnSOD in cytoplasmic and nuclear extracts or in total cell extracts of NHEKs K18FC at the exponential growth phase and at the senescent plateau.
	0.56	IkappaBalpha and MnSOD was performed.
18633101	0.88	IkappaBalpha protein abundance (A) and mRNA expression of IL-6 (B) and SOD2 (C) were measured in lean, obese, and type 2 diabetic (T2DM) subjects.
	0.84	IkappaBalpha was detected by Western blotting (A), NFkappaB p65 activity was measured by ELISA (B), and IL-6 (C), SOD2 (D), and TLR4 (E) gene expression were quantitated by real-time PCR.
20843272	0.88	Mn-SOD, NF-kappaB inhibitor protein, IkappaBalpha, the tumor suppressor protein, p53, and a number of undefined proteins are transiently nitrated after an exposure to a clinically relevant dose of radiation.
18695674	0.86	IkappaBalpha and SOD2 reporters.
18588690	0.83	NFKBIA, INHBA, SOD2, MARCKS, RFX5.
23797602	0.79	MnSOD, TNF and CCL-20 was markedly reduced in cells pretreated with MTA, while induction of IkappaBalpha was not affected (data not shown).
24721172	0.79	IkappaBalpha and SOD2 genes in HCT116 cells.
26539195	0.76	NFKBIA, IRF1, RUNX3), apoptosis regulators (TNFAIP3, TNFAIP6, CFLAR), and enzymes SOD2 and IDO.
26130719	0.72	MnSOD, catalase, IkappaBalpha, VEGF, Zeb1, Snail and Bcl-2, additional genes were identified in our microarray analysis to be targeted and regulated by DDB2, e.g. NEDD4L.
17324256	0.58	SOD2 and other inflammatory response genes S100A8, S100A9, NFKBIA, NFKBIE, GBP1, GBP2.