Publication for NDUFS2 and NDUFV1

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
hsa	NDUFS2	NADH:ubiquinone oxidoreductase core subunit S2	4720			[link]
hsa	NDUFV1	NADH:ubiquinone oxidoreductase core subunit V1	4723

Pubmed ID	Priority	Text
31115493	0.97	NDUFS2, NDUFS3, NDUFS7, NDUFS8, NDUFV1 and NDUFV 2) that contain the following cofac-tors: A flavin mononucleotide (FMN) molecule; 7-9 FeS clusters [including the (2Fe-2S)N1b, (4Fe-4S)N3, (4Fe-4S)N4, (4Fe-4S)N5, (4Fe-4S)N6a/b and (4Fe-4S)N2 clusters]; and the final electron accepting iron-sulfur cluster (N2 cluster), which was recently found to deliver electrons to ubiquinone binding sites.
20818735	0.96	NDUFV1), NuoG (NDUFS1), NuoC (NDUFS3), NuoD (NDUFS2), NuoI (NDUFS8), NuoB (NDUFS7).
22641634	0.96	NDUFS2, NDUFS4, NDUFS7, NDUFS8, and NDUFV1) have been associated with LS and leukodystrophy.
24705504	0.96	NDUFS2, NDUFV1, revealed distinct co-regulated gene expressions, compared to the mtDNA-encoded subunit genes, indicating sub-clustering gene expression.
27308474	0.96	NDUFS2, and NDUFV1 from complex I to trigger ROS production.
29207195	0.96	NDUFS2, NDUFV1, SUCLG1, SUCLG2, UQCRFS1) (Fig. 4C).
29747424	0.96	NDUFS2, NDUFS3, NDUFV1) of complex I have been found to play an important role in both caspase-dependent and caspase-independent apoptotic pathways.
20376309	0.95	NDUFS2, NDUFV1, NDUFA10, NDUFC2 and NDUFB11 and the second including NDUFB10, NDUFA1 and NDUFA12.
	0.89	NDUFS2, NDUFA1, NDUFA10, NDUFA12, NDUFB10, NDUFC2 and NDUFV1) formed a distinct expression cluster, the concept of co-regulation is partially supported.
	0.54	NDUFV1 and NDUFS2).
20426862	0.95	NDUFV1, NDUFV2, NDUFS1, NDUFS2, NDUFS3, NDUFS6, NDUFS7, NDUFS8, ND1, ND4, ND5, NDUFA1, NDUFA8, NDUF13, NDUFAF1, and NDUFB9), Complex II (succinate dehydrogenase) (SDHA, SDHB, SDHC, and SDHD), Complex III (cytochrome bc 1) (UQCRB, CYTB), Complex IV (cytochrome c oxidase) [COX3 (cyclooxygenase 3)], and other genes (APP, amyloid beta, presenin-1, and alpha-synuclein).
26462158	0.95	NDUFV1, NDUFV2 and NDUFS1), while the remainder belong to the Q-module (NDUFS2, NDUFS3, NDUFS7 and NDUFS8).
29506874	0.95	NDUFV1, NDUFV2, NDUFS1, NDUFS2, NDUFS3, NDUFS7 and NDUFS8), in addition to 31 supernumerary subunits, whose exact roles are yet to be fully defined.
31262031	0.95	NDUFS2, NDUFS5, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NOS1, PRDX3, SOD1, UQCRC1, UQCRC2, UQCRFS1, UQCRQ, DLAT, PDHX, COX5B, COX7A1, and TXN2 (fold changes and p-values can be seen in Supplementary Table S4).
30481564	0.92	NDUFV1 at T-383, NDUFV2 at T-164, NDUFV3 at S-530, NDUFS2 at S-364, NDUFAF1 at S-450, NDUFA12 at T-142, NDUFB5 at S-128 and NDUFB6 at S-550), and CIII subunit (UQCRC1 at T-266).
27516145	0.91	NDUFV1, and NDUFV2 belong to NADH dehydrogenase module and NDUFS2, NDUFS3, NDUFS7, and NDUFS8 belong to hydrogenase module.
	0.91	NDUFV1, NDUFV2, NDUFS2, NDUFS3, NDUFS7, and NDUFS8.
	0.90	NDUFV1, and NDUFV2 mainly functions on oxidizing NADH and hydrogenase module (Q module) including NDUFS2, NDUFS3, NDUFS7, and NDUFS8 mainly functions on reducing ubiquinone.
	0.83	NDUFV1, and NDUFV2 in NADH dehydrogenase module and NDUFS2, NDUFS3, NDUFS7, and NDUFS8 in hydrogenase module, low NDUFS1 RNA expression level and high NDUFS8 RNA expression level are most significantly associated with poorer overall survival (P < 0.000001).
	0.62	NDUFS2, NDUFS3, NDUFS7, NDUFS8, NDUFV1, and NDUFV2 being core subunits of mitochondrial complex I, we further analyzed the correlation between their IHC expression levels in clinical NSCLC specimens.
20819849	0.90	NDUFS2, NDUFS3, NDUFS4, NDUFS7, NDUFS8, NDUFV1, NDUFV2 and NDUFAB1) were sequenced in a cohort of 34 paediatric patients with demonstrated isolated complex I deficiency in skeletal muscle.
	0.90	NDUFS2, NDUFS4 and NDUFV1; however, these same reports and others also describe no changes in intracellular reactive oxygen species levels in cells with NDUFS4, NDUFA1 or NDUFV1 mutations.
21494430	0.90	NDUFS2, NDUFV1, PPA2, SDHA, SDHB, SDHC and UQCRFS1), REDOX (GPX1, GSTZ1 and PRDX1), and neurotransmitter production and transport (ABAT, AGXT, CAD, DDC, GAD1, GLS2, GLUD1, GPT, SLC25A18 and SLC25A22).
28259101	0.90	NDUFV1, NDUFV2, NDUFS2, and NDUFS3 are oxidized after reoxygenation provoking a decrease in protein stability.
22342700	0.87	NDUFS2 proteins in supercomplexes started to be detected around 15-24 h after doxycycline removal and reached maximum levels at time 96 h. However, the NDUFS4 and NDUFV1 subunits appeared in such structures between 48-72 h after removing the drug, indicating that the initial incorporations of these two subunits within the supercomplexes were delayed in comparison with the NDUFA9 and NDUFS2 subunits.
	0.62	NDUFS2 is an early-assembly subunit that forms subcomplexes of the peripheral arm ubiquinone reduction (or Q) module; NDUFA9 is an intermediate-assembly subunit that is thought to be located in the boundary between the peripheral arm and the hydrophobic membrane arm (or P module); and NDUFV1 and NDUFS4 are constituents of the peripheral arm NADH dehydrogenase (or N) catalytic module that are crucial to the final steps of CI assembly.
29416685	0.87	NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, and NDUFV3), four genes for complex II succinate coenzyme Q reductase (SDHA, SDHB, SDHC, and SDHD), eight genes for complex III coenzyme Q cytochrome c reductase (BCS1L, CYC1, UQCR11, UQCRC1, UQCRC2, UQCRFS1, UQCRH, and UQCRQ), 14 genes for complex IV cytochrome c oxidase (COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A2, COX7A2L, COX7B, COX8A, and COX8C), and 25 genes for complex V ATP synthase (ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6V0A2, ATP6V0D2, ATP6V1C2, ATP6V1E2, ATP6V1G3, LHPP, OXA1L, PPA1, and PPA2) (Figure 4A).
31249651	0.81	NDUFV1, NDUFS1, and NDUFS2, which reduced GB-mediated ROS production, also inhibited GB-induced apoptogenic factor release; thus, GB induction of mitocentric ROS promotes apoptogenic factor release upon MOMP.
	0.68	NDUFV1, and NDUFS2.
26684010	0.77	NDUFV1, NDUFV2, NDUFS2, NDUFS7 and NDUFS8 subunits, respectively) and the small domain of the 75 kDa subunit (orthologue of the human NDUFS1 protein).
22644603	0.75	NDUFS2, one patient with a mutation in NDUFS3, 14 patients with a mutation in NDUFS4, six patients with a mutation in NDUFS6, six patients with a mutation in NDUFS7, three patients with a mutation in NDUFS8, 17 patients with a mutation in NDUFV1 and one patient with a mutation in NDUFV2 were found.
25030182	0.75	NDUFV1, NDUFV2, NDUFS1, NDUFS2, NDUFS3, NDUFS7 and NDUFS8 as well as Complex I assembly factors..
18691415	0.67	NDUFS2, NDUFS7, NDUFV1) are down-regulated, suggesting a prominent role by cetuximab in impairing mitochondrial function.
24642831	0.66	NDUFS2 (n=2), MPV17 (n=2), RARS2 (n=2), DGUOK (n=2), NDUFV1 (n=1), TK2 (n=1), SUCLA2 (n=1), TMEM70 (n=1)) (Supplementary Table 2).
27597947	0.59	NDUFS2, and NDUFV1) and accessory (NDUFB5, NDUFB6, and NDUFB7) subunits are oxidatively damaged in PD brains, resulting in CI misassembling and functional impairment (Keeney et al.,).
24746669	0.54	NDUFV1, S105 on NDUFV3, S364 on NDUFS2, S55/S29/T5 on NDUFB6 and T142/T120 on NDUFA12).
30831029	0.51	NDUFV1 (51 kD) to ubiquinone (UQ) in a binding site surrounded by NDUFS2 (49 kD), ND1, and NDUFS7 (PSST) subunits (Figure 5A).