Publication for NDUFS1 and NDUFS2

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
hsa	NDUFS1	NADH:ubiquinone oxidoreductase core subunit S1	4719			[link]
hsa	NDUFS2	NADH:ubiquinone oxidoreductase core subunit S2	4720

Pubmed ID	Priority	Text
26115722	0.97	NDUFS1, NDUFS2, NDUFS3 were believed to belong to the minimal assembly required for catalysis.
	0.51	NDUFS1 NDUFS2 NDUFS3 is for oxidative phosphorylation process; EEF1D led VCP and NSFL1C to regulate Golgi/Endoplasmic Reticulum functions; SLC9A3R1 and EZR are important proteins on the cell membrane and cytoskeleton.
21494430	0.97	NDUFS1, NDUFS2, NDUFV1, PPA2, SDHA, SDHB, SDHC and UQCRFS1), REDOX (GPX1, GSTZ1 and PRDX1), and neurotransmitter production and transport (ABAT, AGXT, CAD, DDC, GAD1, GLS2, GLUD1, GPT, SLC25A18 and SLC25A22).
31262031	0.97	NDUFS1, NDUFS2, NDUFS5, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NOS1, PRDX3, SOD1, UQCRC1, UQCRC2, UQCRFS1, UQCRQ, DLAT, PDHX, COX5B, COX7A1, and TXN2 (fold changes and p-values can be seen in Supplementary Table S4).
27516145	0.96	NDUFS1, NDUFV1, and NDUFV2 belong to NADH dehydrogenase module and NDUFS2, NDUFS3, NDUFS7, and NDUFS8 belong to hydrogenase module.
	0.73	NDUFS1, NDUFV1, and NDUFV2 mainly functions on oxidizing NADH and hydrogenase module (Q module) including NDUFS2, NDUFS3, NDUFS7, and NDUFS8 mainly functions on reducing ubiquinone.
	0.68	NDUFS1, NDUFV1, and NDUFV2 in NADH dehydrogenase module and NDUFS2, NDUFS3, NDUFS7, and NDUFS8 in hydrogenase module, low NDUFS1 RNA expression level and high NDUFS8 RNA expression level are most significantly associated with poorer overall survival (P < 0.000001).
30549037	0.96	NDUFS1 and NDUFS2 in DPSCs treated with BIO and/or WNT-3A (Figure 5e,f).
	0.87	NDUFS1 and NDUFS2).
31249651	0.96	NDUFS1, and NDUFS2; thus, ROS production is necessary for GB-mediated apoptotic DNA damage.
	0.82	NDUFS1, and NDUFS2, which reduced GB-mediated ROS production, also inhibited GB-induced apoptogenic factor release; thus, GB induction of mitocentric ROS promotes apoptogenic factor release upon MOMP.
22641634	0.96	NDUFS1, NDUFS2, NDUFS4, NDUFS7, NDUFS8, and NDUFV1) have been associated with LS and leukodystrophy.
29207195	0.96	NDUFS1, NDUFS2, NDUFV1, SUCLG1, SUCLG2, UQCRFS1) (Fig. 4C).
29416685	0.96	NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, and NDUFV3), four genes for complex II succinate coenzyme Q reductase (SDHA, SDHB, SDHC, and SDHD), eight genes for complex III coenzyme Q cytochrome c reductase (BCS1L, CYC1, UQCR11, UQCRC1, UQCRC2, UQCRFS1, UQCRH, and UQCRQ), 14 genes for complex IV cytochrome c oxidase (COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A2, COX7A2L, COX7B, COX8A, and COX8C), and 25 genes for complex V ATP synthase (ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6V0A2, ATP6V0D2, ATP6V1C2, ATP6V1E2, ATP6V1G3, LHPP, OXA1L, PPA1, and PPA2) (Figure 4A).
20707412	0.95	NDUFS2, and NDUFS1) that functions in the oxidation of NADH and establishes the electrochemical gradient necessary to drive ATP synthesis.
28713939	0.95	NDUFS2 and NDUFS1 were enriched in the Parkinson's disease, Alzheimer's disease and Huntington's disease pathways.
20819849	0.93	NDUFS1 change (c.1222C>T, p.R408C) in an Asian Leigh syndrome patient from a consanguineous family and six compound heterozygous NDUFS2 substitutions in four unrelated white Caucasian infants with Leigh or Leigh-like syndrome (c.353G>A and c.875T>C, c.875T>C and c.1328T>A, c.442G>A and c.875T>C, and c.413G>A and c.998G>A).
	0.91	NDUFS1 mutation in an Asian child with Leigh syndrome, a previously identified NDUFS8 mutation (c.236C>T, p.P79L) in a second Asian child with Leigh-like syndrome and six novel, compound heterozygous NDUFS2 mutations in four white Caucasian patients with Leigh or Leigh-like syndrome.
	0.74	NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS7, NDUFS8, NDUFV1, NDUFV2 and NDUFAB1) were sequenced in a cohort of 34 paediatric patients with demonstrated isolated complex I deficiency in skeletal muscle.
	0.70	NDUFS1, NDUFS2, NDUFS4 and NDUFV1; however, these same reports and others also describe no changes in intracellular reactive oxygen species levels in cells with NDUFS4, NDUFA1 or NDUFV1 mutations.
	0.59	NDUFS1, along with NDUFS4, NDUFS6 and NDUFV1, is located at the tip of the hydrophilic arm of complex I and, in contrast with NDUFS2, incorporates much later in the complex I assembly sequence.
19255735	0.92	NDUFS1, NDUFS2, NDUFS3, NDUFS7, and NDUFS8, supernumerary subunits NDUFS4, NDUFS6, NDUFA11, and NDUFA2, and complex I assembly factors NDUFAF2, NDUFAF1, and C6orf66.
23519235	0.92	NDUFS1, NDUFS2, NDUFS4 and NDUFS8) as well as that of a late assembly subunit NDUFA9 probed in cellular homogenates to verify the effect of NDUFS3 suppression on the related complex I subunit expression levels.
20818735	0.91	NDUFS1), NuoC (NDUFS3), NuoD (NDUFS2), NuoI (NDUFS8), NuoB (NDUFS7).
26462158	0.91	NDUFS1), while the remainder belong to the Q-module (NDUFS2, NDUFS3, NDUFS7 and NDUFS8).
26937358	0.91	NDUFS1, NDUFS2 and NDUFS7 and Cure PSP Genetics Consortium has now found an abnormal heterozygous absence (deletion) of the gene NDUFA12L in association with individual patients with PSP, which represents one of the major tauopathy publications in preparation.
30831029	0.90	NDUFS1 (also known as 75 kD subunit, Figure 5A) contains iron-sulfur clusters (ISC), mediating the electron transfer from FMN in NDUFV1 (51 kD) to ubiquinone (UQ) in a binding site surrounded by NDUFS2 (49 kD), ND1, and NDUFS7 (PSST) subunits (Figure 5A).
	0.61	NDUFS1 and NDUFS2) and 8 Cys residues in 7 supernumerary subunits (Table 2 and Figure 5A).
30782949	0.86	NDUFS2 gene), rs11205591 (NDUFS5), rs4600063 (SDHC), rs3770989 (NDUFS1) and rs10891319 (SDHD).
25857492	0.84	NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS6, NDUFS7) have been shown to cause different clinical phenotypes.
26053550	0.83	NDUFS1 gene (a), the NDUFS2 gene (b), the NDUFS3 gene (c), the NDUFS7 gene (d), the NDUFV1 gene (e), the NDUFS8 gene (f) and the NDUFV2 gene (g) in Han Chinese with and without schizophrenia.
19668377	0.79	NDUFS1), NADP transhydrogenase (NNT), 5-methyltetrahydrofolate-homocysteine methyltransferase reductase (MTRR), polymerase gamma (POLG), NADH dehydrogenase 2 (NDUFS2) were among others found to be down-regulated in the 'D' group (Table 2).
31115493	0.76	NDUFS1, NDUFS2, NDUFS3, NDUFS7, NDUFS8, NDUFV1 and NDUFV 2) that contain the following cofac-tors: A flavin mononucleotide (FMN) molecule; 7-9 FeS clusters [including the (2Fe-2S)N1b, (4Fe-4S)N3, (4Fe-4S)N4, (4Fe-4S)N5, (4Fe-4S)N6a/b and (4Fe-4S)N2 clusters]; and the final electron accepting iron-sulfur cluster (N2 cluster), which was recently found to deliver electrons to ubiquinone binding sites.
22644603	0.74	NDUFS1, 15 patients with a mutation in NDUFS2, one patient with a mutation in NDUFS3, 14 patients with a mutation in NDUFS4, six patients with a mutation in NDUFS6, six patients with a mutation in NDUFS7, three patients with a mutation in NDUFS8, 17 patients with a mutation in NDUFV1 and one patient with a mutation in NDUFV2 were found.
26550561	0.74	NDUFS1 and NDUFS2, and early-onset SZ (onset <=18 years), supporting a possible involvement of mitochondrial dysfunction and the temporal variation of SZ symptom onset.
25943107	0.57	Ndufs1, Ndufs2, Sdha, Uqcrc1), 'tricarboxylic acid (TCA) cycle' (Aco2, Idh3g, Ogdh, Ogdhl, Pck2, Pc).
25030182	0.54	NDUFS1, NDUFS2, NDUFS3, NDUFS7 and NDUFS8 as well as Complex I assembly factors..
24918087	0.52	Ndufs 1 and Ndufs 2.