Publication for HSPD1 and CCT8

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
hsa	HSPD1	heat shock protein family D (Hsp60) member 1	3329			[link]
hsa	CCT8	chaperonin containing TCP1 subunit 8	10694

Pubmed ID	Priority	Text
30302013	0.98	HSPD1, RPS3, HSPA8, P54, HNRNPM, TCP1, VIM, HSP90AA1, MATR3, SYNCRIP, YMHAE, EEF1G, FLNA, HNRNPA2B1, PTBP1, ATP5A1, CCT3, RBMX, CCT8, ANXA2, CLTC, HNRNPU, LMNA, AHNAK, and FLNB (Fig. 3A).
	0.96	CCT8: T-complex protein 1 subunit theta; CKAP4: Cytoskeleton-associated protein 4; CLIC4: Chloride intracellular channel protein 4; CLTC: Clathrin heavy chain 1; COPG: Coatomer subunit gamma; CS: Citrate synthase; CSE1L: Exportin-2; CYCS: Cytochrome c, somatic; DDX3X: ATP-dependent RNA helicase DDX3X; DDX3Y: ATP-dependent RNA helicase DDX3Y; DDX58: Probable ATP-dependent RNA helicase DDX58; DLST: Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex; DNM1L: Dynamin-1-like protein; ECHS1: Enoyl-CoA hydratase; EEF1G: Elongation factor 1-gamma; EEF2: Eukaryotic elongation factor 2 kinase; EIF3A: Eukaryotic translation initiation factor 3 subunit A; EIF3E: Eukaryotic translation initiation factor 3 subunit E; EPRS: Bifunctional glutamate/proline-tRNA ligase; ERH: Enhancer of rudimentary homolog; FASN: Fatty acid synthase; FLNA: Filamin-A; FLNB: Filamin-B; FLNC: Filamin-C; FUS: RNA-binding protein FUS; G6PD: Glucose-6-phosphate 1-dehydrogenase; GAPDH: lyceraldehyde-3-phosphate dehydrogenase; GART: Trifunctional purine biosynthetic protein adenosine-3; GBP1: Guanylate-binding protein 1; GFPT1:Glutamine-fructose-6-phosphate aminotransferase [isomerizing] 1; GNA12: Guanine nucleotide-binding protein subunit alpha-12; HABP4: Intracellular hyaluronan-binding protein 4; HADH: Hydroxyacyl-coenzyme A dehydrogenase; HERC4: Probable E3 ubiquitin-protein ligase HERC4; HIST1H3A: Histone H3.1; HNRNPA2B1: Heterogeneous nuclear ribonucleoproteins A2/B1; HNRNPAB: Heterogeneous nuclear ribonucleoprotein A/B; HNRNPCL1: Heterogeneous nuclear ribonucleoprotein C-like 1; HNRNPM: Heterogeneous nuclear ribonucleoprotein M; HNRNPU: Heterogeneous nuclear ribonucleoprotein U; HNRNPUL2: Heterogeneous nuclear ribonucleoprotein U-like protein 2; HSP90AA1: Heat shock protein HSP 90-alpha; HSPA2: Heat shock-related 70 kDa protein 2; HSPA8: Heat shock cognate 71 kDa protein; HSPD1: 60 kDa heat shock protein; HSPE1: 10 kDa heat shock protein IARS: Isoleucine-tRNA ligase; IGF2BP3: Insulin-like growth factor 2 mRNA-binding protein 3; ILF3: Interleukin enhancer-binding factor 3; IMMT: MICOS complex subunit MIC60; INTS5: Integrator complex subunit 5; IPO7: Importin-7; ITGB1: Integrin beta-1; KHSRP: Far upstream element-binding protein 2; KRT18: Keratin, type I cytoskeletal 18; LMNA: Prelamin-A/C; LMNB2: Lamin-B2; MANF: Mesencephalic astrocyte-derived neurotrophic factor; MATR3: Matrin-3; MDH1: Malate dehydrogenase; MDH2: Malate dehydrogenase; MKI67: Proliferation marker protein Ki-67; MMS19: MMS19 nucleotide excision repair protein homolog; MRPS17: 28S ribosomal protein S17; MTOR: Serine/threonine-protein kinase mTOR; MYL6B: Myosin light chain 6B; MYO1B: Unconventional myosin-Ib; MYO1C: Unconventional myosin-Ic; NAP1L4: Nucleosome assembly protein 1-like 4; NASP: Nuclear autoantigenic sperm protein; NCL: Nucleolin; NCSTN: Nicastrin; NDRG1: N-myc downstream-regulated gene 1 protein; NME2: Nucleoside diphosphate kinase B; NPC2: NPC intracellular cholesterol transporter 2; NT5C2: Cytosolic purine 5'-nucleotidase; NUDT1: 7,8-dihydro-8-oxoguanine triphosphatase; P4HA1: Prolyl 4-hydroxylase subunit alpha-1; P54: Non-POU domain-containing octamer-binding protein(NONO); PAFAH1B3: Platelet-activating factor acetylhydrolase IB subunit gamma; PCK2: Phosphoenolpyruvate carboxykinase [GTP]; PCNA: PCNA-associated factor; PDCD11: Protein RRP5 homolog; PDCD5: Programmed cell death protein 5; PDGFRA: Platelet-derived growth factor receptor alpha; PDIA3: Protein disulfide-isomerase A3; PDIA4: Protein disulfide-isomerase A4; PDIA6: Protein disulfide-isomerase A6; PELP1: Proline-, glutamic acid- and leucine-rich protein 1; PGK1: Phosphoglycerate kinase 1; PGM1: Phosphoglucomutase-1; PHB: Prohibitin; PHB2: Prohibitin-2; POLR2B: DNA-directed RNA polymerase II subunit RPB2; PPP5C: Serine/threonine-protein phosphatase 5; PRDX6: Peroxiredoxin-6; PRPF8: Pre-mRNA-processing-splicing factor 8; PSAP: Prosaposin; PSF: Splicing factor, proline- and glutamine-rich(SFPQ); PSMA1: Proteasome subunit alpha type-1; PSMA2: Proteasome subunit alpha type-2; PSMA7: Proteasome subunit alpha type-7; PSMB4: Proteasome subunit beta type-4; PSMD1: 26S proteasome non-ATPase regulatory subunit 1; PTBP1: Polypyrimidine tract-binding protein 1; RALY: RNA-binding protein Raly; RARS: Arginine-tRNA ligase; RBMX: RNA-binding motif protein, X chromosome; RPL10: 60S ribosomal protein L10; RPL10A: 60S ribosomal protein L10-1; RPL24: 60S ribosomal protein L24; RPL27: 60S ribosomal protein L27; RPL5: 60S ribosomal protein L5; RPLP0: 60S acidic ribosomal protein P0; RPS20: 40S ribosomal protein S20; RPS21: 40S ribosomal protein S21; RPS25: 40S ribosomal protein S25; RPS3: 40S ribosomal protein S3; RPSA: 30S ribosomal protein S1; RSL1D1: Ribosomal L1 domain-containing protein 1; RTCD1: RNA 3'-terminal phosphate cyclase; SEC.
29954368	0.98	HSPD1 (upregulated in Basal, Luminal B and HER2), SEC63 (upregulated in HER2), TCP1, CCT4, CCT7, CCT8 (upregulated in HER2 and Basal), HSP90AA1 (upregulated with a near 0.9 log2 fold-change in Luminal B, HER2 and Basal), HSPH1 (upregulated in Luminal B, HER2), DNAJA2, HSPA9, HSPA4, DNAJC13, and HSPA8.
31101846	0.98	CCT8, HSP60) from KM plotter cohort significantly associated with overall survival (p <= 0,05).
20193073	0.97	hsp60 genes encoded in the human genome to: a) nine canonical cct genes (CCT1 to CCT8 including CCT6A and CCT6B) involved in formation of the CCT complex; b) the cpn60 gene (HSPD1) of mitochondrial origin; c) the three highly diverged hsp60-like BBS genes MKKS, BBS10 and BBS12; and d) a newly characterized class of genes, CCT8L, represented in human by CCT8L1 and CCT8L2.
	0.90	hsp60-like BBS genes originated monophyletically from a gene duplication event in the CCT8 gene lineage.
	0.79	Hsp60-like BBS proteins are monophyletic (bootstrap support 86%) and that their common ancestor derived from a duplication event in the CCT8 lineage (bootstrap support 88%).
31514477	0.96	HSPD1, as well as all genes encoding the TRiC complex (TCP1 and CCT2-CCT8).