Publication for HSPD1 and CCT4

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
hsa	HSPD1	heat shock protein family D (Hsp60) member 1	3329			[link]
hsa	CCT4	chaperonin containing TCP1 subunit 4	10575

Pubmed ID	Priority	Text
22205027	0.97	GroEL in SR-B-overexpressing HEK 293 cells.
	0.82	SR-B receptors function as TLR-independent mediators of bacteria-induced signaling triggered by the bacterial wall compound LPS, as well as by cytosolic proteins such as bacterial cpn60 - GroEL.
	0.77	cpn60 and the known recognition of these motifs by SR-B, we predicted that GroEL might be another candidate ligand for class B scavenger receptors.
	0.77	GroEL, the effects of heat treatment on the cytokine-inducing activity of GroEL as well as of LPS were analyzed using HEK293 cells expressing 3 types of SR-B receptors.
29954368	0.96	HSPD1 (upregulated in Basal, Luminal B and HER2), SEC63 (upregulated in HER2), TCP1, CCT4, CCT7, CCT8 (upregulated in HER2 and Basal), HSP90AA1 (upregulated with a near 0.9 log2 fold-change in Luminal B, HER2 and Basal), HSPH1 (upregulated in Luminal B, HER2), DNAJA2, HSPA9, HSPA4, DNAJC13, and HSPA8.
	0.93	HSPD1, CCT2, HSPA4, DNAJC6, CCT5, SEC63, HSPH1, CCT8, CCT4, HSP90AA1, HSPA8, DNAJC13, HSPA9 and TCP1) with a poor prognosis (Table 1).
24079818	0.96	CCT4, HSP90AB1, HSPA1A, HSPA8, HSPB1, HSPD1, HSPH1, and TCP1 (Figure 6B).
21503141	0.91	CCT4 and HSPD1), and the G protein OLA1.
31101846	0.89	CCT4 and CCT6A) from the TCGA cohort and 22/96 HSPs (HSPA1A, HSPA1B, HSPA2, DNAJA1, DNAJC2, DNAJC5, DNAJC5G, DNAJC9, DNAJC16, DNAJC27, DNAJC20, HSPB1, HSPB5, HSP90AA1, CCT1, CCT2, CCT3, CCT5, CCT6A, CCT7, CCT8, HSP60) from KM plotter cohort significantly associated with overall survival (p <= 0,05).
20140087	0.78	CCT4, CCT5, CCT7), t-complex 1 (TCP1), heat-shock 60-kDa protein 1 (HSPD1), heat-shock 70-kDa protein 4 (HSPA4), heat-shock protein 70-kDa protein (HSPA5, HSPA8, and HSPA9), heat-shock protein 90 kDa alpha (HSP90AA1), heat-shock protein 90-kDa alpha class B member 1(HSPAB1), heat-shock protein 90-kDa beta member 1 (HSP90B1), and calnexin (CANX), among which HSPA5, A8, and A9 are involved in an apoptotic pathway and HSPB1, in the p38 MAPK pathway.
21655096	0.55	HSPD1, HSPB1, CCT4 and CCT7; many of the bound genes are involved in protein folding (p-value: 8.4e-17), protein metabolism and modification (p-value: 2.2e-8), protein complex assembly (p-value: 2.9e-5) and stress response (p-value: 2.8e-4) (Table S8).