Publication for Siglec1 and Timd4

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
mmu	Siglec1	sialic acid binding Ig-like lectin 1, sialoadhesin	20612			[link]
mmu	Timd4	T cell immunoglobulin and mucin domain containing 4	276891

Pubmed ID	Priority	Text
25563986	0.98	TIM-4hi) subset of CD169+ M2-like tissue-resident macrophages is a major subset of tissue-resident macrophages and is present in normal as well as transplanted hearts.
	0.98	TIM-4hi subset of CD169+ M2-like tissue-resident macrophages the favors (5X fold) preferential induction of antigen-stimulated Tregs in the mixed lymphocyte response.
	0.98	TIM-4hi, CD169+ tissue-resident macrophages are immunoregulatory and promote engraftment of cardiac allografts but their influence is diminished by TIM-4-dependent programmed cell death.
	0.97	CD169+ tissue-resident macrophages are resistant to oxidation stress-induced apoptosis in TIM-4-/- mice.
	0.96	TIM-4hi subset of Ly6C-CD169+ tissue-resident macrophages: 1) constitutes a major subset of Ly6C- tissue-resident macrophages, 2) homes to draining lymph nodes following oxidative stress, a major site for T cell activation, 3) exhibits an immunoregulatory and hypostimulatory phenotype that is maintained following migration to dLNs, 4) favors preferential induction of antigen-stimulated Tregs, 5) is highly susceptible to apoptosis, and 6) is rendered resistant to apoptosis via genetic ablation of TIM-4 expression.
	0.94	TIM-4 monoclonal antibodies able to protect the TIM-4hi subset of CD169+ M2-like tissue-resident macrophages from apoptosis will promote long-term engraftment and tolerance.
26943809	0.98	CD169+TIM-4+ TRM subset in heart and skin that migrates upon activation to draining lymph nodes, produces TGFbeta, induces FoxP3+ Tregs, and promotes allograft survival.
	0.97	CD169+TIM-4+ cells are increased in abundance but remain at the islet perimeter in pre-diabetic and diabetic NOD mice (S1 Fig).
	0.97	CD169, TIM-4 and CX3CR1 (Fig 2C) as compared to IRDCs.
	0.95	TIM-4+CD169+ cells are present at the islet perimeter in C57BL/6 mice.
	0.84	CD169+TIM-4+ cells are located at the islet perimeter in C57BL/6 and NOD mice
	0.84	CD169+TIM-4+ (Fig 1 and S1 Fig) cells at the islet perimeter in B6 mice.
21037090	0.98	TIM-4 and with cells expressing CD169 (Fig. 3A), a marker for marginal metallophilic macrophages located in the splenic marginal zone, which have been shown to play a critical role in clearance of apoptotic cells.
	0.98	TIM-4-expressing CD169+ metallophilic macrophages reside.
	0.96	TIM-4 and CD169 mAbs, and treatment with anti-TIM-4 mAb in vivo delayed clearance of apoptotic cells in this site.
25066922	0.98	TIM-4, the only non-T cell TIM protein, is expressed on macrophages, a population of CD11c+ DCs, CD169+ (MOMA-1+) marginal metallophilic macrophages, and some peritoneal B cells.
23770640	0.97	CD169, MARCO, SIGN-R1 and Tim-4 was selectively lost in LXR-DKO spleens (Fig. 1a-c).
	0.96	CD169, MARCO and Tim-4 expressing cells in the MZ compartment in mice transplanted with Lenti-LXRalpha transduced cells (Fig. 6b).
27828940	0.96	Siglec1 and Timd4) were expressed in sorted phagocytes but not in IECs.
31324781	0.96	SIGLEC1, SIRPA, MERTK, TIM4, CX3CR1, and ITGAX (CD11c), including a recently described long-lived population.