Publication for FOXC1 and FOXC2

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
hsa	FOXC1	forkhead box C1	2296			[link]
hsa	FOXC2	forkhead box C2	2303

Pubmed ID	Priority	Text
22991501	0.98	FOXC1, FOXC2) and EMT-regulated genes (E-cadherin, N-cadherin, and Vimentin) in HCC tissues.
	0.74	FOXC1[1617] and FOXC2 and the zinc-finger, E-box-binding proteins Zeb1 and Sip1(Zeb2)[1920].
19274050	0.97	FOXC1, FOXC2, FOXP2 and FOXP3.
	0.97	FOXC1 FOXC2 Foxo1 FOXP1 FOXP2 FOXP3 FOXP4 Irs1 Irs2 pha-4
29449899	0.97	FOXC1 and FOXC2, appear to play novel roles in cancer progression.
30722065	0.96	FOXC1 and FOXC2 have been reported, including missense and nonsense mutations, small deletions and insertions.
	0.95	FOXC2 binding motif in FOXC1 binding sites in human cells.
	0.90	FOXC1 (gray) and FOXC2 (black).
	0.90	FOXC1 and FOXC2.
	0.85	FOXC1 or FOXC2 occur in a variety of cancers such as breast carcinoma, hepatocellular carcinomas, lymphoma and so on.
25093829	0.96	FOXC1 and FOXA2, two in FOXC2, and single non-synonymous variants were found in GATA4, TBX20, HAND2 and FOXH1.
	0.94	FOXC1 p.P297S, FOXC2 p.Q444R, FOXH1 p.S113T and TBX1 p.P43_G61del PPPPRYDPCAAAAPGAPGP.
	0.86	FOXC1 that affected reporter transactivation and found changes in FOXH1, FOXC1 and FOXC2 that had previously been shown by others to have affect transactivation capacity.
	0.76	FOXC1 p.P297S, FOXC2 p.Q444R, FOXH1 p.S113T and TBX1 p.P43_G61del PPPPRYDPCAAAAPGAPGP .
30360388	0.96	FOXC2, similar to FOXC1, also has a vital role in the carcinogenesis of various cancers.
	0.96	FOXC1 and FOXC2 have essential roles in the EMT process, angiogenesis, and target cancer stem cells.
	0.96	FOXC1 and FOXC2 share some phenotypic features through various signaling pathways that promote tumor progression and metastasis.
23919753	0.96	FOXC2 were upregulated, while FOXC1 and SNAI1 (Snail) were downregulated by CSE in MCF 10A cells (Figure 5D).
	0.68	FOXC2 were upregulated, while FOXC1 and SNAI1 (Snail) were downregulated by CSE.
24526833	0.96	FOXC1, FOXC2, NOTCH1, TWIST1 and MBD3 are predicted to be up-regulated by MYC and STAT3 or ARNT and STAT3 in both 90 A and 72 A cohorts.
	0.96	FOXC1, ARNT and FOXC2 are transcriptional regulators in angiogenesis.
29202800	0.96	FOXC1, FOXC2 and TWIST1.
	0.67	foxc-1, foxc-2 and twist1 expressions in the cells treated with genistein (200 mumol/L) and TNF-alpha (10 ng/mL) respectively for 48 h were determined by RT-PCR analysis.
27999212	0.96	FOXC1/PAX6/ITGbeta1; C. resveratrol/miRNA-520h/PP2A/C/Akt/NF-kappaB/FOXC2; D. Galpha12/AP-1/miR-135b/FOXO1-Galpha12/miR-194/MDM2/FOXO1; E. miR-22-miR-486/PTEN/PI3K/AKT/FOXO1; F. TGF-beta/FOXO1/miR-21/AKT/NF-KB/Snail; G. AR/PI3K/AKT/FOXO3/AP-1/miR-21/PTEN; H. miR-34a-146b-132-21-217/Sirt/FOXO1.
17062144	0.95	foxc1 linkage, however again the foxf1-foxc2-foxl1 cluster appears broken, and foxc2 appears to have been lost.
	0.87	FOXC2, FOXF1 and FOXQ1 are found on chromosome 6 within 70 kb, while the genes FOXL1, FOXC1, FOXF2 are found on chromosome 16 within 300 kb.
	0.72	FoxC1 genes, but suggest such constraints, if they exist, are less likely on the organisation of the FoxF1-FoxC2-FoxL1 genes.
28122229	0.95	FOXC1 and FOXC2, respectively) in blood-flow- and cilia-impaired embryos (gata1 morphants and CBD-treated embryos, respectively) (Figures 6B and 6C).
	0.86	FOXC1 and FOXC2 are induced by shear stress.
	0.56	FOXC1 and FOXC2 are activated by LSS in arterial ECs (Figure 6A).
28435457	0.95	FOXC1 and FOXC2 induced the expression of arterial markers in vitro and worked in conjunction, at an earlier stage, to precisely control the proper process of arterial specification, by regulating the expression of Notch signaling genes, such as Dll4.
	0.70	FOXC1 and FOXC2, and also directly interacted with the VEGF signaling pathway to promote arterial gene expression.
28397860	0.95	FOXC1, FOXC2 and PITX2.
31212881	0.94	FOXC1, FOXC2, PITX2, LMX1b, and PAX6.
	0.90	Foxc1 and NC-Foxc2 enables the identification of malformations in the embryonic period as the joint expression of these genes regulates early development of some ocular structures.
27276711	0.94	FOXC1/FOXC2 response elements was detected in 50% of mutations, while the remaining ones caused an increase of protein transactivation activity.
27013924	0.93	FoxC1 and FoxC2 are responsible for the repression of the GNDF action in the rostral mesenchyme adjacent to the ND.
28288141	0.93	FOXC1 together with FOXC2, another member of the FOX family, control developmental processes, such as somitogenesis.
25848863	0.92	FOXC1, FOXC2 and FOXQ1, contribute to the aggressive phenotype of BLBC.
	0.92	FOXC1, FOXC2, and FOXQ1 are highly expressed in basal-like subtype breast cancer, but are less present in luminal subtype cancer.
22522965	0.92	FOXC1 or FOXC2 have congenital heart defects, whereas FoxC2 is implicated in tumor angiogenesis and metastasis.
30657791	0.91	FOXC1 and FOXC2, and it is also present in the periocular mesenchyme.
	0.70	FOXC2 is structurally and functionally closely related to FOXC1.
19185813	0.89	Foxc2 and a related Fox protein, Foxc1, play a critical role in determining an arterial cell fate by acting upstream of Notch signaling during embryonic development.
21915264	0.86	FOXC2 (3.96 fold), and FOXC1 (1.29 fold) (Fig. 3C).
21712985	0.83	FOXC1 transcripts did not differ among the three groups of biopsies ( Figure 3D ) while FOXC2 expression was significantly higher in rapidly progressive IPF and normal biopsies compared with biopsies from slowly progressive IPF patients ( Figure 3E ).
27103944	0.77	FOXC1 and FOXC2 mutant embryos identified a wide spectrum of cardiac abnormalities, including cardiac inflow and outflow dysplasia and abnormal formation of the epicardium.
27539549	0.77	FOXC1, and FOXC2 among others) endowing breast tumor cells with enhanced self-renewal, tumor initiating capacity, invasiveness and resistance to apoptosis 26, 28, 96, 97, 98.
24967590	0.75	FOXC1 and FOXC2, two forkhead box TFs.
	0.72	FOXC1 and FOXC2
27570485	0.71	FOXC2, seven human FOX genes, including FOXC1, FOXE1, FOXE3, FOXL2, FOXN1, FOXP2 and FOXP3 have been identified as disease-causing mutations.
29552326	0.61	FOXC1 and FOXC2 are need for the morphogenesis of the cardiac outflow tract.
28344652	0.59	FOXC1 and FOXC2 genes are expressed during cardiac development, and mutations in these genes have been associated with a wide range of cardiac abnormalities.