Publication for CLCA2 and CLCA4

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
hsa	CLCA2	chloride channel accessory 2	9635			[link]
hsa	CLCA4	chloride channel accessory 4	22802

Pubmed ID	Priority	Text
31404307	0.98	CLCA2 and CLCA4 gene expression levels at different TNM stages.
	0.96	CLCA2, it has been identified that ectopic expression of CLCA4 results in the inhibition of breast cancer cell growth.
	0.95	CLCA2 and CLCA4 are significantly associated with an improved OS time for patients with colon cancer (P<0.001, P=0.012 and P=0.039, respectively).
	0.91	CLCA2 and CLCA4 in normal tissue were observed.
	0.86	CLCA2 and CLCA4 in tumor tissues were associated with a favorable OS time in all patients with colon cancer, which suggests that CLCA1, CLCA2 and CLCA4 act as tumor suppressors in colon cancer.
	0.82	CLCA4 was misidentified as CLCA2 in a study conducted by Bustin et al.
	0.77	CLCA2, CLCA3 and CLCA4 were higher in the normal colon tissue when compared with that in the primary colon cancer tissue.
	0.65	CLCA2 and CLCA4 gene expression levels according to data from The Cancer Genome Atlas.
24386311	0.97	CLCA4, like CLCA2, contributes to differentiation in breast.
	0.97	CLCA4, CLCA2, and pLex vector were packaged and transduced into MCF7, and colonies were selected with puromycin for two weeks then stained with crystal violet in methanol.
	0.97	CLCA4, like E-cadherin and CLCA2, is a marker of epithelial differentiation that is lost when cells transition to a mesenchymal phenotype.
	0.96	CLCA4 is like CLCA2 a marker of epithelial differentiation in breast, we used Oncomine and NextBio to consult transcriptional profiles from cell culture systems that model mammary epithelial differentiation.
	0.96	CLCA4 and CLCA2 was appoximately eightfold higher in the Matrigel population (Table 1).
	0.96	CLCA4 expression was 56-fold higher and CLCA2 was seven times higher in the differentiated population.
	0.96	CLCA2 knockdown construct, Tripz1, into the previously established CLCA4 knockdown cell line H4C.
	0.95	CLCA4 was misidentified as CLCA2 in that study).
	0.95	CLCA4 and CLCA2 transfected into 293 T cells.
	0.94	CLCA4 in immortalized cells by shRNAs caused downregulation of epithelial marker E-cadherin and CLCA2, while mesenchymal markers N-cadherin, vimentin, and fibronectin were upregulated.
	0.92	CLCA4 is also induced by stress and by conditions that promote epithelial differentiation such as growth on permeable membranes or suspension in extracellular matrix; that CLCA4 is required to maintain differentiation, as its attenuation caused EMT; and that ectopic expression of CLCA4 similarly inhibits proliferation of breast cancer cells, as transduction of either CLCA2 or CLCA4 into MCF7 resulted in microcolonies of enlarged cells.
	0.91	CLCA4 or CLCA2 produced microcolonies of enlarged cells (Figure 2C).
	0.89	CLCA4 is induced by stress but more weakly than CLCA2.
	0.89	CLCA4 and CLCA2.
	0.86	CLCA4 in parallel with CLCA2 (Figure 2B).
	0.85	CLCA4 expression with tumor progression suggested that CLCA4, like CLCA2, might antagonize tumorigenesis.
	0.85	CLCA4 is highest in the most trypsin-resistant fraction, correlating with E-cadherin and CLCA2.
	0.84	CLCA4 and CLCA2 play complementary but distinct roles in epithelial differentiation.
	0.82	CLCA2 and CLCA4.
	0.78	CLCA2, and CLCA4.
	0.70	CLCA4 has a similar structure to CLCA2, while CLCA1 lacks a transmembrane segment.
	0.59	CLCA4 also downregulated CLCA2, suggesting cooperative action of the two genes in epithelial differentiation (Figure 5C).
19210762	0.97	CLCA2 and CLCA4 genes are widely expressed in brain, and at particularly high levels in the optic nerve, human CLCA3, the closest homologue of mouse Clca1, Clca2 and Clca4, is not expressed in the brain.
	0.97	hCLCA2 and hCLCA4 expression were found in cerebral cortex, cerebellum and spinal cord (Fig 7B).
	0.89	hCLCA2 and hCLCA4 in optic nerve exceeded 58 and 35 times the expression level of the corresponding gene in cerebral cortex.
	0.64	hCLCA2 and hCLCA4 are expressed in the CNS of adult humans.
	0.54	hCLCA2 and hCLCA4 was also significantly higher in medulla and olfactory tract as compared to the expression level in cerebral cortex.
23341073	0.97	CLCA4 and CLCA1 is observed in our colon tumor samples, these highly homologous chloride channel proteins may function as tumor suppressors in colon cancer, as has been shown for the proposed TP53-induced tumor suppressor, CLCA2, in breast cancer.
27618016	0.96	CLCA2 and CLCA4 (chloride channel accessory protein-2, -4) suppress EMT in breast cancer cells possibly by counteracting oncogenic alkalinization of intacellular pH. In addition, CLCA2 has been shown to be a p53 target gene that transcriptionally inactivates focal-adhesion kinase (FAK) and thereby inhibits invasion.
	0.71	CLCA2 or CLCA4 mimics TGFbeta1-induced EMT.
30419838	0.94	CLCA2, and CLCA4.
	0.76	CLCA2 and CLCA4 may serve as tumor suppressors in breast cancer.
26930581	0.94	CLCA4, lack this sequence, suggesting that interaction with EVA1 is intrinsic to CLCA2.
25635880	0.83	CLCA2, CLCA4, or ORAOV1 that could compensate for its function for olfactory ability.
	0.64	CLCA2 and CLCA4 are members of the chloride channel accessory family named CLCA and may be involved in mediating calcium-activated chloride conductance.
31375088	0.82	CLCA2, and CLCA4) along with a pseudogene (CLCA3P).
31995732	0.72	CLCA4 proteins contain an intact MIDAS motif, whereas most CLCA2 family members do not, missing one or two key residues (Figure 3A).
	0.72	hCLCA4 (NM_012128.3), pCLCA4a (XM_001926978.5), pCLCA4b (XM_003125934.5), mCLCA4a (NM_207208), mCLCA4b (NM_001033199), hCLCA2 (NM_006536.6), pCLCA2 (XM_003125930.4), mCLCA2 (NM_178697.5), mCLCA3b (NM_139148), mCLCA3a1 (NM_009899), and mCLCA3a2 (NM_030601) (where h, human; p, pig; m, mouse).
29346439	0.72	CLCA2 and CLCA4 which are thought to be membrane-bound.
24349268	0.63	hCLCA2, hCLCA3 and hCLCA4, the three murine homologues mCLCA1, mCLCA2 and mCLCA3, the bovine bCLCA1, the bovine lung endothelial cell adhesion molecule-1 bCLCA2, and the porcine pCLCA1.
25603912	0.63	CLCA2, and CLCA4.
27212225	0.60	CLCA2 and CLCA4 are downregulated in human colorectal tumors, in contrast, CLIC1 in gastric cancer and CLIC3 in pancreatic cancer have been shown to be upregulated.
28974231	0.58	CLCA2, is highly expressed in the trachea and mammary glands, while CLCA4 is mostly expressed in neural tissue (note that CLCA4 was misidentified as CLCA2 in the study conducted by Agnel M, et al.).
25548429	0.54	CLCA2 protein belongs to the calcium sensitive chloride conductance protein family and one of three CLCA proteins (CLCA1, CLCA2, and CLCA4).
22731784	0.53	CLCA2 is mainly expressed in the trachea, while CLCA4 is mainly expressed in the colon and trachea.
29463274	0.51	hCLCA2, hCLCA3, hCLCA4), and all members of this protein family share a high degree of homology in protein size, sequence and predicted structure but differ significantly in tissue distribution and biological function.
30312171	0.51	CLCA4 is a member of the CLCA family, which has similar primary structure with CLCA1 and CLCA2.