Publication for Zic1 and Zic3

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
mmu	Zic1	zinc finger protein of the cerebellum 1	22771			[link]
mmu	Zic3	zinc finger protein of the cerebellum 3	22773

Pubmed ID	Priority	Text
30297839	0.98	Zic1 and Zic3 were broadly expressed in the neural plate.
	0.98	Zic family, has been shown to increase the paraxial mesoderm progenitors at the primitive streak cooperatively with Zic3.
	0.97	Zic expression profiles, several upstream signaling and trans-acting factors have been described for Zic1 and Zic3.
	0.97	Zic1-NE, Zic1-ME, Zic3-NE1, Zic3-NE2, and Zic3-ME directed the spatially restricted expression in neural or mesodermal tissue.
	0.97	Zic1 and Zic3 expression during embryonic development.
	0.95	Zic1 and Zic3 (Fig. 1d-f,j-m).
	0.95	Zic1-NE (neural enhancer), Zic3-NE1 (neural enhancer 1), Zic3-NE2 (neural enhancer 2) directed the reporter gene expression (Fig. 2B-D).
	0.95	Zic1 and Zic3 CNE-driven reporters were similar to those in chicken embryos, indicating that the enhancer functions are evolutionary conserved between mouse and chicken.
	0.94	Zic1 and Zic3 expression in the neural folds showed anterior-posterior profiles similar to those in the HH6 stage, but the signal was enhanced in the lateral region of the neural plate as seen in the cross sections (Fig. 1a-c,g-i).
	0.94	Zic1 and Zic3.
	0.93	Zic1 expression was accentuated at the anterior end of the telencephalic vesicle, diencephalon and hindbrain region and Zic3 expression was enhanced in the broad region of the telencephalic vesicle, mesencephalic region, and some segments in hindbrain region.
	0.93	Zic3-ME contains the predicted TF binding sites for Nanog, Oct4, T, Eomes, LEF1, and Zic proteins at the sites of their ChIP-seq peaks (Figs 6 and 7, Supplementary Figs S5 and S6).
	0.92	Zic3 expression can be seen in the epiblast of the prospective anterior neuroectodermal region and along the primitive streak, but Zic1 expression was faint at an area near the anterior primitive streak.
	0.92	Zic1-ME (mesodermal enhancer) reporter expression was observed weakly at somites, whereas Zic3-ME reporter expression was strong at both unsegmented paraxial mesoderm and somites (Fig. 2B-D, Supplementary Fig. S1), mimicking distribution of Zic1 and Zic3 transcripts (Fig. 1).
	0.87	Zic3 expression was observed strongly at both somites and unsegmented mesoderm, and modest Zic3 expression was observed at the notochord progenitors; whereas, Zic1 expression was observed at dorsomedial somites.
	0.68	Zic1 and Zic3 mRNA distribution at later stages [e.g. at HH10-24, at HH7-13] and distribution of the Zic proteins at HH8-23.
	0.56	Zic1 expression was enhanced in the anterior region, whereas Zic3 expression increased posteriorly.
21211521	0.98	Zic1-/- and Bent Tail (Zic3-/-) mutant embryos activate Myf5 normally during somite formation (data not shown).
	0.97	Zic1 and Zic2, but not Zic3, potentiate the transactivation of Gli-dependent Myf5 epaxial somite-specific (ES) enhancer activity in 3T3 cells, and Zic1 activates endogenous Myf5 expression in 10T1/2 cells and in presomitic mesoderm explants.
	0.81	Zic1, Zic2, and Zic3 function in Myf5 regulation, we assayed their ability to transactivate Gli reporters in 3T3 cells, which express Gli2 and Gli3, but not Zic RNAs.
31189106	0.98	ZIC transcription factors therefore show dynamic changes in their expression that accompany the transitions to EpiLCs, and the transient expression kinetics of ZIC3 in particular indicates that this is a likely candidate for controlling the transition phase.
	0.91	ZIC3 motifs located in the ZIC binding regions (Figures 3F, S7F, and S7G).
	0.87	ZIC3 functions in the early ESC transitions are modified by other ZIC family members later in the differentiation and development program.
32117005	0.98	Zic1, Zic2, and Zic3 are expressed in the NPCs residing in the septum and cortical hem, the sites of generation of the Cajal-Retzius (CR) cells.
	0.97	Zic1, Zic2, Zic3, Zic4, and Zic5) are expressed in the specific regions of neuroectoderm during the early embryonic phase in mice, and they have essential roles in CNS development.
	0.95	Zic1, Zic2, and Zic3 result in an inadequate division of forebrain, which fails to develop into two hemispheres.
23999067	0.98	ZIC3 is a member of the ZIC family of transcription factors, which are related to GLI proteins that mediate hedgehog signaling, a conserved developmental pathway important for left-right patterning .
	0.96	1 allele (Zic3NeoIn1/NeoIn1 or Zic3NeoIn1/y genotypes), which will hereafter be referred to as Zic3 hypomorphs, were shown to have a universal reduction of Zic3 expression by real-time RT-PCR (qPCR) (Figure 1B).
15345369	0.98	Zic1 through Zic3.
20199689	0.98	Zic proteins are present in the primitive meninx (meningeal cell precursors), and a deficiency of Zic2 or Zic1/Zic3 results in impaired proliferation and differentiation of meningeal precursors.
20826668	0.98	Zic1, Zic2 and Zic3 have overlapping patterns of expression and are essential for development of forebrain midline structures during embryogenesis .
21251809	0.98	Zic1 and Zic3 are zinc-finger transcription factors that are expressed in the meninges in addition to subsets of cells in the developing forebrain.
25699711	0.98	Zic3, another Zic family member that is highly expressed in ES cells (Figures 3D-F).
27881878	0.98	Zic1 and Zic3 are required together to regulate forebrain development and cooperate in promoting neural progenitor expansion, while inhibiting neuronal differentiation, while Zic1 also promotes neural precursor formation and maintenance throughout the neural tube.
29243319	0.98	zic1 and zic3 has been proposed in mouse.
23471918	0.97	Zic3 molecule to interfere with the function of other Zic proteins.
	0.96	Zic1, Zic2 and Zic3 also contain a conserved region within the N-terminal portion of the protein called the ZOC motif.
	0.95	Zic proteins, 88.5% of the wild-type V5-ZIC3-wt protein was found within the nucleus.
	0.94	Zic3 protein that lies upstream of the zinc finger does not possess dominant-negative activity and does not interfere with the function of other coexpressed Zic proteins.
	0.83	ZIC3-associated heterotaxy, and for studies of Zic protein interactions and transcriptional surveillance mechanisms.
	0.70	ZIC3-associated heterotaxy but also for studies of Zic protein interaction and transcriptional surveillance mechanisms.
16162033	0.97	Zic1, and Zic3 transcription factors, which subsequently lead to Ncam1 and neural tubulin expression.
	0.95	Zic1, Zic3, and Ncam1.
	0.82	Zic1, Zic3, and Sox2 were all part of the DP signature and absent in Mc.
22355535	0.97	Zic family of proteins is highly conserved, Zic2 might function to expand the medial forebrain cholinergic neural progenitor cells by inhibiting their exit from the proliferating cell cycle in a manner analogous to that in the Zic1/Zic3 compound mutant mice.
	0.96	Zic1/Zic3 compound mutant mice.
24362763	0.97	Zic1-/-;Zic3-/- mice have smaller OBs, suggesting that Zics regulate OB neurogenesis.
	0.96	Zic1 and Zic3 are sparsely expressed in the OB in the superficial granule cell layer (GL), mitral cell layer (MCL), and external plexiform layer (EPL), where Type 1-4 cells are located.
19731547	0.97	Zic1 and Zic3 transcription factor proteins.
19864579	0.97	Zic1, Zic3, Zic4, and Zic5), and areal patterning (Pax6).
30266956	0.97	Zic3 is expressed in the medial SVZ, Zic1 and Zic2 are expressed in the dorsal SVZ, where they act in inducing CalR+ PG interneurons while repressing a dopaminergic fate.
28990928	0.96	Zic1, and Zic3 at the same stringency, despite the absence of MNs in the forebrain of embryos.
	0.88	Zic1, Six1, Dmrta2, Otx1, and Zic3) and enriched in DP, or in posterior spinal identity (Hoxb8, Hoxb3, Hoxb2, Hoxb4, Hoxb5, Hoxd4, Lhx3, Olig2, and Nkx6-1) and enriched in SP.
23612715	0.96	Zic1, Zic2, and Zic3 but expression of Zic1 and Zic2 gradually disappears during retinal development, while Zic3 expression continues into adulthood.
28814342	0.95	Zic3-lacZ displayed a dorsal to ventral gradient, similar to Zic proteins stained by panZic antibody, in the E18.5 septum.
	0.92	Zic3-lacZ transgene was largely restricted to the Zic+ medial telencephalon, with only a few scattered cells occasionally observed in the ventricular zone (VZ) of the rostroventral LGE (Fig. 1A-G).
	0.89	Zic3-lacZ transgene showed a dorsal-high to ventral-low gradient in the septum, and although this pattern was consistent with that of endogenous Zic proteins, its expression was mosaic.
	0.56	Zic3 gene and overall Zic proteins (Fig. 1E-G).
23606270	0.95	Zic1 and Zic2 expression, as well as strong Zic3 expression, was observed lateral to the developing inner ear (black arrowheads, Fig. 4L, 4M, 4N).
27915011	0.95	Zic1 and Zic3 were markedly downregulated (9.9- and 5.2-fold, respectively) at 9-hrs (Table 2), whereas, Zic1 and Zic4 were significantly upregulated (2.5- and 2.4-fold, respectively) at 12-hrs (Table 3) after in utero AzaD exposure.
21170309	0.93	ZIC3 have been suggested to have partially overlapping or redundant roles in suppressing endoderm in embryonic stem cells, the role of ZIC1 in this context has been not been explored much.
	0.79	ZIC1, despite sharing 69% homology with ZIC3, does not show the same trend in expression in either mouse or human pluripotent stem cells.
20553611	0.93	Zic1, Zic2, or Zic3 expression is compromised.
26382291	0.93	ZIC1 and ZIC3 are amongst the genes with the highest numbers of predicted binding motifs in the CEs (Table 1).
29391420	0.92	Zic3, raising the possibility that ZIC family proteins can target two types of sequences.
	0.75	ZIC1 and ZIC3 consensus sequences defined by a high-throughput SELEX analysis contains both a stretch of C nucleotides and the CTGCTG core motif adjacently (Fig. 6).
20704721	0.88	Zic3 double mutants exhibit craniorachischisis though this may be a result of exencephaly and severe spina bifida, rather than a failure of closure 1; genetic interaction between Zic mutants and the PCP pathway has not been assessed.
21336820	0.85	Zic1 and Zic3 null mutations results in severely impaired forebrain development, which is not obvious in either of the single mutants.
29207951	0.84	Zic1 and Zic3 in ipsilaterally versus contralaterally-projecting RGCs, we also investigated whether either of these molecules had the ability to bind to the intracellular domain of Ten-m3.
22623663	0.70	Zic1 and Zic3 (F,H,J) and not Bmp4 and Wnt3a (L,M).
31297611	0.68	Zic3 were not detected in d7 or d14 cells, and the homeobox genes Zic1 and Dlx5 were only expressed in the d7 cells, despite these having been reported in the NC of a range of species (Table 2); however, Meis homeobox 2 (Meis2) was expressed in both d7 and d14 cells.