Publication for Otx2 and Zic1

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
mmu	Otx2	orthodenticle homeobox 2	18424			[link]
mmu	Zic1	zinc finger protein of the cerebellum 1	22771

Pubmed ID	Priority	Text
25335464	0.98	OTX2, a TF whose expression is upregulated in EpiSCs and that, together with POU3F1 and ZIC proteins, has been suggested to play a role in the maintenance of EpiSC self-renewal.
30999923	0.98	Zic, Otx2 and Pou factors for the neural development and formation of neural progenitor cells (NPCs).
29167563	0.97	Otx2, Pax6, FoxA2 and Zic1 expression indicative of regional specification.
	0.97	Otx2, dorsal transcription factor Pax6, as well as absence of the ventral marker, FoxA2, and hindbrain marker, Zic1 (Fig. 2D-K).
	0.97	Zic1 and surpression of Otx2 expression (Fig. 2P-S).
	0.92	Zic1 and lack of Otx2 immunoreactivity in conjunction with motor (Islet1) and serotonergic (5-HT) neuronal markers.
31639368	0.97	Otx2 and Pax2 alongside the canonical NC regulators Sox9, Zic1-3, Smad2/3, and NR2F2, as putative core regulators of the NC-GRN, displaying previously unappreciated connectivity to downstream, neural effector genes.
	0.95	Otx2-Pax2 (p = 6.7 x 10-50), Otx2-Sox9 (p = 4.2 x 10-30), Pax2-Sox9 (p = 8.5 x 10-24), NR2F2-Otx2 (p = 1.4 x 10-22), Otx2-Zic1/2/3 (p = 2.9 x 10-11), and NR2F2-Sox9 (p = 1.6 x 10-10) among others, highlighting known and integrating new core transcriptional circuitry underlying NC-derived neural progenitors into our current view of the NC-GRN.
	0.95	Otx2-Lhx2 and Smad3-Pax2, into BCHE, BMPER1, and TFAP2C, and Otx2-Zic1/3 into RXRb, with additional inputs (NR2F2, Arnt2, Meis1/2, Sox8-10) contributing to individual enhancers (Figure 6K).
26166575	0.97	Zic1 locus (data not shown) suggesting direct regulation by OTX2.
	0.97	Otx2 mutants has consequences for subpallial development, including GP agenesis (or, loss of molecular identity based on ER81, Lhx6, Lhx8, Nkx2.1, Zic1; Figures 7, S4).
28990928	0.97	Otx2, Otx1, Crx, Six1, Dmrta2, Zic1, and Zic3 at the same stringency, despite the absence of MNs in the forebrain of embryos.
	0.88	Otx2, Crx, Zic1, Six1, Dmrta2, Otx1, and Zic3) and enriched in DP, or in posterior spinal identity (Hoxb8, Hoxb3, Hoxb2, Hoxb4, Hoxb5, Hoxd4, Lhx3, Olig2, and Nkx6-1) and enriched in SP.
24361252	0.97	Otx2, Nestin, Pax6, Fabp7, Zic1 for ectoderm/ neuroectoderm, and Cdx2 for trophoectoderm (Figure 2C-D & S2B-C).
24905168	0.96	Otx2 consensus binding motif, Zic and Oct4 motifs were also highly overrepresented at Otx2-bound regions in EpiLCs (Figure S5B).
	0.84	Otx2 or Zic motif are bound more strongly in EpiLCs.