Publication for Thbs2 and Tnc

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
mmu	Thbs2	thrombospondin 2	21826			[link]
mmu	Tnc	tenascin C	21923

Pubmed ID	Priority	Text
31639302	0.98	Thbs2, Tnc), and 9 genes encoding modulators of remodeling (Adamts1, Adamts2, Ctgf, Mmp14, Mmp2, Tgfbi, Timp1, Timp2, Timp3) indicated that graphene foam provided a microenvironment conducive to expression of genes that are important in early chondrogenesis.
	0.96	Thbs2, and Postn increased at early chondrogenic time points and then plateaued, while Tnc, Fn, and Thbs1 increased throughout the time course of the experiment (Figure 11E, G, and I).
	0.96	Tnc, Fn, Sparc, Spp1, Thbs1, Thbs2, and Postn consistent with or enhanced compared to levels observed under control conditions for chondrogenesis, and these levels were slightly reduced in the presence of fibronectin (Figure 11F, H, and J).
	0.94	Thbs2, and Tnc.- The upregulation of these genes supports our conclusion that 3D-GF provides an environment supporting of chondrogenic differentiation and that while fibronectin facilitates cell adhesion, it does not improve the cellular response.
32157178	0.98	tenascin-C (Tnc), spondin 2 (Spon2), periostin (Postn), thrombospondin 2 (Thbs2), and the marker of remodeling, Adam33 (Fig. 2C).
	0.97	Tnc, Postn, Spon2, Thbs2) as a key lung morphogenetic event associating with eosinophils.
19857613	0.98	Tnn (1.8-fold), fibulin 2 (Fbln2, 3.0-fold), laminin-alpha 4 (Lama4, 2.4-fold), lambin-beta 1, subunit 1 (Lamb1-1, 2.4-fold), glycoprotein 38 (Gp38 (4.0-fold) and thrombospondin 2 (Thbs2, 3.1-fold).
21632951	0.98	Thrombospondin2, Tenascin C, Vimentin and Adamts1 (Figure 5c), were up-regulated in Dicer-deficient cerebella.
22114461	0.98	thrombospondin 2, and tenascin C as well as lysyl hydroxylase which is important in collagen crosslinking as demonstrated in mouse studies.
28588076	0.98	TnC, Spp1, Thbs1, Thbs2, Thbs 4, Ctgf, and Sparc (Table).
28700594	0.98	Thbs2 and Thbs4), as well as the matrix components Fibronectin (Fn1), Syndecan-1 (Sdc1), and Tenascin-C (Tnc) (Fig 7A and 7B), suggesting that TGFbeta alteration of cell-matrix interaction may contribute to its aggregative effect.
32198421	0.98	Tnc, Fn1, Thbs2, Lox, and Serpinb2, have been shown to promote metastatic progression.
29022912	0.97	Tnc, Thbs2, Acta2 and Tgfb1 compared with WT mice.
	0.96	tenascin C (Tnc), thrombospondin 2 (Thbs2), alpha smooth muscle actin (Acta2) and transforming growth factor beta 1 (Tgfb1) in Tnmd-/- samples (Figure 2i).
31077243	0.97	Thbs2/4, Tnc, Tnn, Pdgfra), cytoskeleton proteins (e.g., Actn2, Cav1, Flnc, Myl2, Mylk4), and the main calnexin (Cx43/Gja1) that composes the gap junction between osteocytes.
32095779	0.97	tenascin-C, thrombospondin 2, and TGFbeta1 were downregulated in tenomodulin knockouts, but scleraxis was upregulated, along with chondrogenic genes, COMP and proteoglycan 4.
27129287	0.91	Tnc, Thbs2 and Comp) were annotated in the pathway of ECM-receptor interaction, which were mostly significantly enriched with the differentially expressed genes in the MI samples compared with the sham control ones (P=5.66E-16).
	0.85	Thbs2, Spp1, Itgb8, Col1a2, Fn1, Tnc and Tlr4) and was significantly enriched with differentially expressed genes (P=8.78E-10).
	0.78	Tnc, Col5a1, Comp, Col5a2, Fn1, Thbs4, Col1a2 and Thbs2), the protein digestion and absorption signalling pathway (annotated with Col1a1, Col14a1, Col5a1, Col1a2, Col12a1, Col3a1, Col5a2, Kcnq1 and Cpa3) and the Toll-like receptor signalling pathway (annotated with Tlr4, Ctsk, Tlr8 and Spp1) were all significantly enriched with the differentially expressed genes in the MI samples compared with the sham control samples (Table 1).
32083813	0.78	tenascin C (Tnc), thrombospondin 2 and 4 (Thbs2, Thbs4), transforming growth factor beta 1 (Tgfb1), alpha smooth muscle actin (Acta2), ephrin type-A receptor 4 (Epha4), asporin (Aspn), and fibromodulin (Fmod), without affecting those of collagens III and VI (Col3a1, Col6a1), eyes absent homolog 1 and 2 (Eya1, Eya2), sine oculis homeobox homolog 1 and 2 (Six1, Six2), cartilage oligomeric protein (Comp), lubricin (Prg4), biglycan (Bgn), decorin (Dcn), fibronectin (Fn), lysyl oxidase (Lox), lumican (Lum), procollagen-lysine, 2-oxoglutarate-5-dioxygenase 1 (Plod1), and transglutaminase 2 (Tgm2) in Tnmd - / - compared to WT mice (Figure 2d).
18632874	0.57	Thbs2, Tnc, and Tns1), in the Wnt/hedgehog/smoothened signaling pathway (dapper homology 1 (Dact1), patched homolog 2 (Ptch2), and secreted frizzled-related protein 1 (Sfrp1),Wnt inhibitory factor 1 (Wif1), SUMO/sentrin specific peptidase 2 (Senp2), and suppressor of fused homology (Sufu)), and in the categories of transcriptional regulation, mRNA processing and mRNA nuclear transport, including ATF6, Runx1, Foxk2, E2F3, Ets1, Etv5, Gli1, Ep400, Nr4a2, and Nr4a1.