Publication for FBLN1 and FBLN2

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
hsa	FBLN1	fibulin 1	2192			[link]
hsa	FBLN2	fibulin 2	2199

Pubmed ID	Priority	Text
28097151	0.98	Fbln1, Fbln2, and Fbln5 encode a secreted glycoprotein that is incorporated into a fibrillar extracellular matrix.
	0.97	Fbln1, Fbln2, and Fbln5).
	0.97	Fbln1, Fbln2, and Fbln5).
	0.94	Fbln1 and Fbln2).
	0.92	Fbln1, and Fbln2.
	0.66	Fbln1, Fbln2, and Fbln5) (Table 2).
31508361	0.97	fibulin-1 and fibulin-2 (100 and 200 kDa, respectively) and is characterized by the three anaphylatoxin modules in domain I. In addition, fibulin-2 differs from fibulin-1 because it contains two regions in domain I with additional differences: one rich in cysteines (the cys-rich domain) and the other lacking this amino acid (the cys-free domain).
	0.95	fibulin-1 and ADAMTS-1 or of fibulin-2 and ADAMTS-12 could be considered a good prognostic factor in breast cancer.
	0.94	fibulin-2 seems to be compensated for by an increase in fibulin-1 expression, which, in turn, compensates for the absence of fibulin-2.
	0.83	fibulin-1, opposing functions have been described for fibulin-2.
	0.51	fibulin-1, to other factors such as posttranslational modifications, interactions with other components of the ECM, fibulin-2 site of expression within the cancerous tissue or even the clinical grade or stage of the tumor.
28099917	0.97	Fibulin-2 can be proteolytically processed by MMPs and serine proteases involved in tissue remodeling processes, whereas its closest partner Fibulin-1 is more resistant to this proteolysis.
	0.93	Fibulin-1, the closest partner of Fibulin-2, is not a substrate but it can act as a cofactor of ADAMTS-1.
	0.70	Fibulin-2 could also act in a similar manner than Fibulin-1 does on ADAMTS-1 activity.
27826254	0.97	Fibulin-1 is present in the amorphous core of the elastic fiber (Roark et al.,), fibulin-2 colocalizes with fibrillin-1 (El-Hallous et al.,).
	0.87	Fibulin-1 is detectable in hepatocytes, activated HSCs and MFBs but fibulin-2 expression is restricted to MFBs.
18985039	0.97	FBLN1 and FBLN2 (fibulin 2) were found to be downregulated and acted as tumour suppressive genes in certain cancers such as prostate cancer and breast cancer (Wlazlinski et al, 2007; Yi et al, 2007).
19230968	0.97	fibulin 1 and fibulin 2, consists of larger proteins containing an extra domain with 3 anaphylatoxin modules and additional EGF-like modules.
28177909	0.97	fibulin-1, fibulin-2, fibulin-3, fibulin-4, fibulin-5, fibulin-6, and fibulin-7.
23856125	0.96	Fbln1, Fbln2, or Fbln3 has no effect on elastic fiber formation.
19652764	0.95	fibulin-1 (FBLN1), fibulin-2 (FBLN2), decorin (DCN) and microfibrillar associated protein 5 (MFAP5)), which were differentially expressed in all AAD patients included in the analysis (Fig. 2).
	0.90	fibulin-1 (FBLN1), fibulin-2 (FBLN2), decorin (DCN) and microfibrillar associated protein 5 (MFAP5), which were differentially expressed in all tissue from AAD.
25139440	0.95	fibulin-1, fibulin-2, fibulin-3 and fibulin-5.
29242531	0.94	FBLN1, ITGA7, ASPN, MFAP2, FBLN2, COL8A2, SPP1, CTSK, ADAMTS9, PRSS1, SPP1, SLC3A1, DPP4, SLC7A8, CPB2, and PRSS1.
	0.73	fibulin 1 (FBLN1), FBLN2, osteoglycin (OGN), nidogen 2 (NID2), Wnt family member 6 (WNT6), asporin (ASPN), integrin subunit alpha 7 (ITGA7), hyaluronan synthase 1 (HAS1), and cathepsin K (CTSK).
29581841	0.94	FBLN1, FBLN2, FBLN3, FBLN4, FBLN5 and FBLN7 were quantified using qPCR (Figure 1A).
31638302	0.91	FBLN2, ADARB1, ZBTB16, ANGPT1, FBLN1, FZD4, OMD, ABI3BP, RGS4, CXCL8) are closely related to bone homeostasis and the process of osteogenic differentiation,31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44 and these studies further supported the reliability of the dataset.
22919265	0.90	fibulin-1 and fibulin-2.
	0.63	Fibulin-1 and fibulin-2 are also slightly larger than the proteins in the second group (~90-100 kDa and 200 kDa, respectively).
19584278	0.90	fibulin-1, fibulin-2 and fibulin-5 was also lower in lung cancer (Fig. 1A).
30124491	0.89	fibulin-1, fibulin-2, and fibrillin-1, and they interact with each other in a calcium-dependent manner.
24213471	0.86	fibulin-1, fibulin-2, fibronectin and fibrillin-1, cross-links these matrix components which facilitates tumor invasion and metastasis.
24401530	0.85	fibulin-1 and fibulin-2, a growing family of ECM proteins that are expressed in particularly high levels in the developing heart valve.
24457941	0.84	fibulin-2 could act as a cofactor for the metalloprotease, similarly to what occurs with fibulin-1 and ADAMTS-1.
	0.52	fibulin-1, the closest molecular partner of fibulin-2.
31452758	0.78	fibulin-1 and fibulin-2 are found to be downregulated in such cancers as prostate and breast cancer and play roles as TSG.
19390655	0.75	fibulin-1, fibulin-2, nidogen-2, perlecan, heparan sulfate, and fibronectin.
31357616	0.75	Fibulin-1 (FBLN1) was described as being up-regulated in high-grade astrocytoma, and Fibulin-2 (FBLN2) and Fibulin-5 (FBLN5) was described as being down-regulated in grade II/III/IV compared with grade I astrocytoma.
31622881	0.72	FBLN2 may perform highly specialized functions directing glomerular vascularization in human kidney development replacing some of the functions of Fbln1 in mouse.
29453284	0.65	fibulin-1, which exists as an interface between elastin and the fibrillin microfibril; and fibulin-2, which co-localizes with elastic fibers in vivo.
30514914	0.52	Fbln1, Fbln2, and Smoc), and matrix-modifying enzymes (Lox and Loxl1) (Fig. 3e).