Publication for Foxc1 and Tfap2b

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
mmu	Foxc1	forkhead box C1	17300			[link]
mmu	Tfap2b	transcription factor AP-2 beta	21419

Pubmed ID	Priority	Text
28253399	0.98	Foxc1/c2, the Pitx2's effector AP-2beta is dispensable for early specification of corneal epithelium and establishment of lymphangiogenic privilege in the cornea, suggesting phenotypic differences among key regulators expressed in NC-derived ocular mesenchyme.
	0.96	Foxc1/c2 mutant embryos at E14.5 exhibit undetectable levels of Pitx2 and its downstream effectors, Dkk2 and AP-2beta, which is reinforced by our finding that the double mutants closely phenocopy both the global and NC-specific mutant mice for Pitx2.
	0.95	NC-Foxc1-/-;NC-Foxc2-/- mutation did not alter Pitx2 expression in the periocular mesenchyme at E11.5 (Fig. 7A); but by E14.5, levels of Pitx2, as well as its downstream effectors Dkk211,12 (a canonical Wnt signaling antagonist) and the AP-2beta transcription factor Tfap2b, were significantly lower in compound NC-Foxc1-/-;NC-Foxc2-/- embryos than in control embryos (Fig. 7B).
	0.94	Tfap2b was normally expressed in the surface ectoderm of the compound NC-Foxc1-/-;NC-Foxc2-/- embryos (Fig. 7B), which indicates that the Wnt1-Cre driver is specific to the NC-derived periocular mesenchyme, not the surface ectoderm.
	0.55	TFAP2B was also strongly expressed in surface ectoderm at similar levels in the control and compound NC-Foxc1-/-;NC-Foxc2-/- eyes (arrows).
29660784	0.98	AP-2beta), although expression was unchanged in single Foxc1 and Foxc2 knockouts, suggesting that both are required for maintaining Pitx2 expression during development.
	0.97	FOXC1, FOXE3, PAX6, LMX1B, GPR48, TFAP2A and TFAP2B.
20960542	0.98	Foxc1, Foxc2, and Tfap2b each encode transcription factors that are essential in the ocular neural crest for normal anterior segment development and function.
26968737	0.97	Foxc1, but not Lmx1b, is dependent on AP-2beta and that reduced FOXC1 levels may contribute to altered development of the corneal endothelium in Tfap2b mutant eyes.
	0.97	Foxc1, but not Lmx1b, depends on AP-2beta and that FOXC1 may act downstream effector of AP-2beta required for normal development of the corneal endothelium.
	0.91	Foxc1 expression is significantly reduced in the absence of AP-2beta.
27483349	0.97	AP-2beta NCC KO model place this transcription factor in a similar regulatory network for anterior segment development as Foxc1 and Pitx2.
	0.88	AP-2beta levels are affected in the absence of Foxc1 and how these three genes interact to direct development of the anterior segment.