Publication for Hnf4a and Creb3l3

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
mmu	Hnf4a	hepatic nuclear factor 4, alpha	15378			[link]
mmu	Creb3l3	cAMP responsive element binding protein 3-like 3	208677

Pubmed ID	Priority	Text
18704925	0.98	CrebH as a transcription factor whose mRNA can be identified in both the embryonic and adult mouse liver and whose expression is dependent on HNF4alpha.
	0.98	HNF4alpha binding site upstream of CrebH coding sequence that was occupied by HNF4alpha in fetal livers and facilitated transcriptional activation of a reporter gene in transient transfection analyses.
	0.98	HNF4alpha in having a role in controlling the acute phase response of the liver induced by ER-stress through regulating expression of CrebH.
	0.98	CrebH (encoded by the gene Creb3l3) as a new target of HNF4alpha regulation, which is expressed in differentiating hepatocytes throughout liver development and is essential for expression of acute phase response proteins induced by ER-stress.
	0.98	CrebH is continuously expressed in the hepatic cells throughout liver development in a manner indistinguishable from HNF4alpha raising the possibility that CrebH is a direct transcriptional target of HNF4alpha.
	0.98	CrebH gene contains an HNF4alpha recognition element that is occupied by HNF4alpha in fetal livers.
	0.98	HNF4alpha is dispensable for intestinal CrebH expression, ChIP analyses revealed that, like the liver, HNF4alpha occupied its binding site within the CrebH promoter in intestinal tissue (data not shown).
	0.98	CrebH is dependent upon HNF4alpha, these results demonstrate that HNF4alpha makes an indirect yet crucial contribution toward the induction of a systemic inflammatory response by ER stress.
	0.97	Hnf4alpha, CrebH mRNA was detected in the definitive endoderm forming the primary liver bud (Fig. 2d,g) and expression continued in the hepatoblasts as they delaminated from the bud and invaded the surrounding septum transversum at E10.5 (Fig. 1e,h).
	0.97	HNF4alpha regulates transcription through an HNF4alpha-binding site within the putative transcriptional regulatory region of the CrebH gene
	0.97	HNF4alpha is essential for expression of CrebH in the fetal liver but dispensable for expression in the small intestine
	0.97	HNF4alpha in this response by mediating CrebH expression.
	0.97	CrebH by HNF4alpha is tissue dependent and importantly that occupancy of a promoter by HNF4alpha in vivo does not necessarily correlate with transcriptional regulation.
	0.97	CrebH promoter that is controlled specifically by intestinal transcription factors thereby obviating any requirement for HNF4alpha.
	0.97	HNF4alpha is essential for expression of CrebH in the liver, but is dispensable for expression in the small intestine
	0.96	CrebH mRNA is restricted to the extraembryonic visceral endoderm and was not detected in the definitive endoderm, as has previously been described for Hnf4alpha.
	0.96	CrebH expression is strictly dependent upon HNF4alpha in the liver we also found that CrebH continues to be robustly expressed in HNF4alpha null small intestines.
	0.96	CrebH expression is independent of HNF4alpha in the small intestine, yet strictly dependent upon HNF4alpha in the liver.
	0.96	CrebH is a direct target of HNF4alpha transcriptional activity
	0.95	HNF4alpha is dispensable for CrebH expression in the gastrointestinal tract but is essential for CrebH expression in the liver.
	0.94	HNF4alpha could occupy the identified binding site within the endogenous CrebH gene in fetal livers using chromatin immunoprecipitation (ChIP) analyses.
	0.93	HNF4alpha binding sites, a known HNF4alpha binding site within the Apoc3 promoter (H4.21) as well as the HNF4alpha binding site within the CrebH gene could be precipitated from chromatin isolated from fetal livers using an antibody that specifically recognizes HNF4alpha.
	0.93	CrebH is dependent on the presence of HNF4alpha raised the question of whether the absence of CrebH could account for any aspect of the phenotype associated with Hnf4alpha-/- fetal livers.
	0.91	CrebH also expressed Hnf4alpha mRNA; although, not all Hnf4alpha positive tissues expressed CrebH.
	0.91	CrebH mRNA was detected in both control and HNF4alpha-null small intestines.
	0.84	HNF4alpha binding site (H4.77) lying 3.7kb upstream of CrebH exon 1 (Fig. 3a).
	0.78	CrebH had the potential to act downstream of HNF4alpha during liver development and function we compared expression CrebH to that of Hnf4alpha during hepatic development.
	0.74	CrebH as a direct target of HNF4alpha.
27417587	0.98	HNF-4alpha was dispensable for Apoa4 promoter activation by CREBH(N) in HEK293T, suggesting that CREBH regulates its target genes through diverse mechanisms.
	0.96	CREBH requires HNF-4alpha to activate Apoa1 and Apoc2 promoters, implicating that CREBH and HNF-4alpha cooperatively regulate these genes.
	0.93	CREBH requires HNF-4alpha to induce apoA-I and apoC-II, but not apoA-IV.
	0.90	CREBH(N) alone, and further increased by HNF-4alpha co-transfection.
	0.77	CREBH(N) and HNF-4alpha protein levels in the co-transfected cells were comparable to those in singly transfected cells, indicating that the synergism is not related to the expression level of each protein (Figure 5D).
29738435	0.98	hepatocyte nuclear factor 4alpha (HNF4alpha):a transcription factor for gluconeogenesis:directly binds to the promoter of CrebH and activates its expression.
	0.98	CrebH expression is induced by the glucocorticoid receptor (GR)/PGC-1alpha complex, and the HNF4alpha/PGC1alpha complex.
	0.97	CREBH and HNF4alpha co-operate to activate Apoa1 expression.
	0.96	HNF4alpha, which activates CrebH expression, also activates hepatic Apoa1 expression.
22262056	0.98	CREB-H is a downstream target gene of hepatocyte nuclear factor 4alpha (HNF-4alpha), which plays a critical role in hepatocyte differentiation and liver function.
	0.98	HNF-4alpha abolished CREB-H mRNA expression in the liver, but not in the small intestine, suggesting an essential role of HNF-4alpha in hepatic CREB-H expression.
	0.92	HNF-4alpha binding site was identified at 3.7 kb upstream of the CREB-H promoter.
19877272	0.98	Creb3l3 (also known as Creb-H), a member of the bZip family of transcription factors, is involved in the endoplasmic reticulum (ER) stress response, and interestingly, its expression in the developing liver is dependent upon Hnf4alpha.
21145844	0.98	Hepatocyte nuclear factor 4alpha (HNF4alpha), a nuclear hormone receptor, essential for differentiated hepatocyte function, regulates CrebH expression in mouse liver, raising the possibility that HNF4alpha via CrebH regulates the acute phase response (APR).
23193188	0.98	CREBH, HNF4, FOXO1, FOXO6, and TR4.
25733154	0.98	CREBH and HNF4alpha.
27131369	0.98	HNF-4alpha, CREB, CREBH, ERR-alpha, PPARalpha and SERBP1 regulate APOA4 expression.
29360258	0.98	CREBH is a transcriptional target of HNF4alpha, which plays integral roles in both liver development and hepatic lipid metabolism.
30733709	0.98	CREBH, GR, constitutive androstane receptor, and HNF4alpha, and represses their transcriptional activities.
31334233	0.98	CREB3L3 expression is regulated by a number of nuclear receptors, including PPARalpha, HNF4alpha, GR, and ERRgamma.