Publication for Pklr and Slc2a2

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
mmu	Pklr	pyruvate kinase liver and red blood cell	18770			[link]
mmu	Slc2a2	solute carrier family 2 (facilitated glucose transporter), member 2	20526

Pubmed ID	Priority	Text
24831725	0.98	Glut2, Pklr, Gck, Gckr, Gys2, Ppardelta, Pcx and Klf15 (Figure 4G, S5).
	0.97	Pklr, Ppardelta, Gck, Gckr, Glut2, Gys2, Dlat, Pcx, and Klf15).
20640476	0.98	GLUT2, pyruvate Kinase (L-PK) and aldolase B, amongst others.
20953342	0.98	Glut-2, Gapdh, Pklr or Fbp1, and G6pc.
21178610	0.98	Glut2, L-PK, ACC, FASN, SCD1 and Elovl6) involved in DNL and MUFA synthesis.
30158026	0.98	Glut2, Pklr, G6pdh), lipogenesis (Acaca, Fasn, Scd1, Elovl6), and triglyceride formation (Gpdh, Dgat2).
29534502	0.97	Pklr) and fructose metabolism genes (Glut2, Glut5, and Khk) in WT mice increased in a time-dependent manner, while the mRNA expression of these genes was much lower in KO mice (Figure 5A-F).
	0.97	Pklr, Glut2, Glut5, and Khk in WT mice increased in a time-dependent manner; however, this induction was diminished in KO mice.
	0.95	Pklr, and Fgf-21) and fructose metabolism genes (Glut2, Glut5, and Khk) was not affected by fructose (Figure 5A-F).
22629359	0.97	Slc2a2 and Pklr expression at ZT13/19 in our control animals.
28327662	0.97	Pklr were decreased by 61-78% at mRNA levels in chow or HCD-fed livers compared to the control counterparts (Fig. 3a; Supplementary Table 2), while glucose transporter 2 (Glut2), Gck, fructose kinase (Khk) and phosphofructose kinase (Pfk) were not significantly affected at mRNA levels.
24270904	0.96	pklr and slc2a2.
	0.91	pklr, while palmitic acid significantly reduced expression of pklr (P<0.05; Figure 2A) and of the GLUT2 encoding gene slc2a2 in NIT-1 cells (P<0.05; Figure 2B).
26015548	0.96	Glut-2; Gck; pyruvate kinase liver and red blood cell (Pklr); glucose-6-phosphatase, catalytic (G6pc); Fasn; and Scd-1 was greater in refed aLivGHRkd mice compared with refed controls.
27094951	0.96	Slc2a2 (GLUT2), Ldha (LDH), Eno1 (Enolase), Pklr (L-PK) and Egln3 (PDH3), suggests a HIF-1alpha-dependent metabolic reprogramming in the liver of PHD1-/- mice promoting glycolysis and pyruvate metabolism.
24149114	0.95	L-PK, the normalized GLUT-2 expression and GK overexpression in these mice may be expected to alleviate glucose dysregulation induced by PM2.5 exposure.
23528177	0.94	Glut2), glycolysis (L-PK), DNL (ACC, FASN), and MUFA synthesis (SCD1, Elovl6).
30150719	0.94	GLUT2, glucokinase (GCK) and its regulator protein GCKR, hexokinase 1 (HXK1), phosphofructokinase (PFKL), 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB1), FBP1 and glucose-6-phosphate dehydrogenase (G6PD)), glycogen metabolism (e.g. glycogen synthase (GYS2) and glycogen phosphorylase (PYGL)) and gluconeogenesis (e.g. catalytic and transporter subunit of glucose-6 phosphatase (G6PC/T), cytosolic/mitochondrial isoforms of phosphoenolpyruvate carboxykinase (PEPCK-C/M), pyruvate carboxylase (PC), pyruvate kinase (PKLR)) as well as the major metformin transporter organic cation transporter 1 (OCT1) between WT and KI under fasted and refed conditions (Fig. 2h and Supplementary Fig. 4).
19181415	0.90	L-Pk, Glut2 and aldolaseB were not significantly changed except that glucokinase was increased in both HNF-1alpha (+/-)/RIP-Tag and HNF-1alpha (-/-)/RIP-Tag beta-cells.
	0.83	L-PK, Glut2, neutral and basic amino acid transporter, insulin and glucagon.
26799318	0.90	Slc2a2; FC 1.78), pyruvate kinase (Pklr; 1.58-fold), phosphoglycerate mutase 1 (Pgam1; FC 1.58) and glucokinase (also hexokinase 4, Gck; FC 2.86).