Publication for Scd2 and Srebf1

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
mmu	Scd2	stearoyl-Coenzyme A desaturase 2	20250			[link]
mmu	Srebf1	sterol regulatory element binding transcription factor 1	20787

Pubmed ID	Priority	Text
31083413	0.98	SREBP-1, including fatty acid synthase (Fas), acetyl-CoA carboxylase 1 (Acc1), stearoyl-CoA desaturase-1 (Scd1), Scd2, glycerol-3-phosphate acyltransferase (Gpam), diacylglycerol O-acyltransferase 1 (Dgat1), and Dgat2, were significantly reduced in arazyme-treated mice (Figure 3A-C).
	0.98	SREBP-1-mediated hepatic lipogenesis-related genes, including Fas, Acc1, Scd1, Scd2, Gpam, Dgat1, and Dgat2.
	0.97	Srebf1, Srebf2, Fas, Acc2, Scd1, Scd2, Gpam, Dgat1, and Dgat2.
	0.97	SREBP-1 and FAS protein levels, as well as SREBP-1 target gene mRNA levels, including Fas, Acc1, Scd1, Scd2, Gpam, Dgat1, and Dgat2, inhibiting hepatic fatty acid and TG synthesis.
	0.94	Srebf1), fatty acid synthase (Fas), acetyl-CoA carboxylase 1 (Acc1), stearoyl-CoA desaturase-1 (Scd1), Scd2, glycerol-3-phosphate acyltransferase (Gpam), diacylglycerol O-acyltransferase 1 (Dgat1), and Dgat2.
19496086	0.98	SREBP1 found here to be regulated by GSPE include genes involved in the synthesis of monounsaturated and polyunsaturated FA: Acetyl-CoA synthetase Acss2/Acsl1, and two stearoyl-coenzyme A desaturases (SCD), Scd1 and Scd2.
	0.97	SREBP1, a key regulator of fatty acid and TG synthesis and lipoprotein metabolism, acyl-CoA synthetase Acss2/Acsl1 (involved in fatty acid synthesis), the fatty acid desaturases Scd1 and Scd2, and several genes encoding cholesterol biosynthetic enzymes.
28143772	0.98	Scd2 as Wnt/beta-catenin target genes which are transactivated by beta-catenin interaction with SREBP-1c bound to the novel SRE site in the proximal promoters.
	0.98	Scd2 promoter (which also contains the novel SRE and both NF-Y sites) by beta-catenin ChIP analysis (Fig. S3F), suggesting both genes are positively regulated by beta-catenin via its interaction with SREBP-1c at the conserved novel SRE sites.
22078880	0.98	SREBP1c, SCD1 and SCD2 in AKO adipose tissue.
23823481	0.98	Srebp1c, Scd1, Scd2, Acaca, Fasn, Dgat1, Dgat2) and lipid uptake (Pltp, Vldlr, Ldlr, Ldrap1, Lpl,) were increased in LOKO fat depots.
24191950	0.98	Srebp1 downstream genes, coding for enzymes which encompass the fatty acid biosynthesis pathway like Acss2, Acaca, Fasn, Scd1, and Scd2, are robustly down-regulated by fasting in our data (Figure 4E, Table 2).
24818992	0.98	SREBP1 overexpressing mice, SCD2 is upregulated.
28481866	0.98	Scd2 and Srebf1) was increased compared with the control liver (Figure 7).
29366871	0.98	Srebf1 (encoding SREBP-1c), Scd (which includes Scd1, Scd2, Scd3 and Scd4), and Acc in both wild-type and Cyp1a1(-/-) mice (Fig. 3B).
30070033	0.98	SREBP-1c and SCD-2 expression in primary hepatocytes, showing well-defined effects of HGF in lipogenic genes21.
30364153	0.98	SREBP1c and enzymes involved in fatty acid remodeling, such as Elovl5, Fads2, Scd1, and Scd2.
30772307	0.98	SREBF1, MOGAT2, SCD2) while inducing lipolysis (CPT1A, CPT2, PPARGC1A).
30929409	0.98	Scd2) and transcription factors such as C/eba, Klf5, Srebf1, and Stat3 that are implicated in fatty acid and phospholipid synthesis.
29593532	0.97	Srebf1, Scd1, Scd2, Fas, Elovl5, Mylip) expression in liver from ApoE-/- mice.
	0.95	SREBP-1 expression and Srebf1 mRNA expression, and this effect was associated with a decrease of lipogenic gene Scd1, Scd2, Fas, Elovl5, and Mylip mRNA expression.
21079772	0.97	Srebf1 and its down-stream target genes (e.g., Scd2, Elovl6, and Acaca), which is crucial in de novo lipogenesis, while other groups of genes involved in lipid uptake, oxidation, and export were not altered (Figure 5).
24203995	0.97	SREBP1, SCD1 and SCD2 in mice.
29632203	0.97	Scd2 in Kupffer cells but not intact liver, consistent with the ability of Scd2 to be activated independently by the LXR and SREBP1 pathways.
31630534	0.96	SCD2, previously identified as a direct downstream target gene of the transcription factor SREBP2 was nearly superimposable on that of SREBP2 (but not SREBP1).
28241068	0.95	Scd2, Srebf1 and Lpcat3 using total RNA isolated from brains of male and female mice of both genotypes (Fig 3C and 3E).
31514294	0.93	SCD-2, and FAS were significantly decreased in the HFD + 0.6% PPF group compared to the HFD control group (all p < 0.001, Figure 5), while there was no difference in the mRNA level of SREBP-1c between the two groups.
28386555	0.92	SREBF1, UCP3, and SCD2 participated in the DGAT1 regulation, which was consistent with our results.
	0.83	SREBF1, PDK4, and PPP1R3C), the MAPK signaling pathway (DUSP1), and the biosynthesis of unsaturated fatty acids pathway (SCD2, UCP3).
21103377	0.75	Scd2, Dgat2, Srebp1c and Acc tended to be decreased (Figure 3B).