Publication for Fasn and Scd2

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
mmu	Fasn	fatty acid synthase	14104			[link]
mmu	Scd2	stearoyl-Coenzyme A desaturase 2	20250

Pubmed ID	Priority	Text
31083413	0.98	fatty acid synthase (Fas), acetyl-CoA carboxylase 1 (Acc1), stearoyl-CoA desaturase-1 (Scd1), Scd2, glycerol-3-phosphate acyltransferase (Gpam), diacylglycerol O-acyltransferase 1 (Dgat1), and Dgat2, were significantly reduced in arazyme-treated mice (Figure 3A-C).
	0.97	Fas, Acc2, Scd1, Scd2, Gpam, Dgat1, and Dgat2.
	0.97	FAS protein levels, as well as SREBP-1 target gene mRNA levels, including Fas, Acc1, Scd1, Scd2, Gpam, Dgat1, and Dgat2, inhibiting hepatic fatty acid and TG synthesis.
	0.97	Fas, Acc1, Scd1, Scd2, Gpam, Dgat1, and Dgat2.
	0.94	fatty acid synthase (Fas), acetyl-CoA carboxylase 1 (Acc1), stearoyl-CoA desaturase-1 (Scd1), Scd2, glycerol-3-phosphate acyltransferase (Gpam), diacylglycerol O-acyltransferase 1 (Dgat1), and Dgat2.
27568222	0.98	Fasn and Scd2 in SAT relative to visceral adipose tissue from the Tg-FABP4-RORalpha4 (Fig. 5A-D).
	0.98	Fasn and Scd2 in SAT from the Tg-FABP4-RORalpha4 line.
21711241	0.98	Fasn (fatty acid synthase), Scd1, Scd2 (stearoyl-Coenzyme A desaturase 1 and 2), and Elovl6 (long chain fatty acid elongase 6).
22495349	0.98	Fasn, Mecr, Scd2, Hadh, Fads6, Fa2h, Elovl5, Acsbg1), glycerolipids (Gpam, Gpd2), or myelin (Npc1, Qk, Mbp, Lgi4, Acsbg1), which were all shown to be downregulated by PIO.
23823481	0.98	Scd2, Acaca, Fasn, Dgat1, Dgat2) and lipid uptake (Pltp, Vldlr, Ldlr, Ldrap1, Lpl,) were increased in LOKO fat depots.
24191950	0.98	Fasn, Scd1, and Scd2, are robustly down-regulated by fasting in our data (Figure 4E, Table 2).
24806461	0.98	Scd2, Fasn, Ldlr, Hmgcs1, Sqle and Lss, demonstrating an inverse relationship between SREBP suppression and activation in ScapDelta/Delta and Insig1/2 Delta/Delta mice, respectively.
26047317	0.98	Fasn, Scd1 and Scd2) were found to be significantly upregulated in Glmp gt/gt relative to WT liver (Fig 4B).
26073941	0.98	Fasn, Scd2, and Lpar1 (Figure S5A), and these genes were rapidly induced in naive sDCs exposed to 4-HNE (Figure S5B).
27903748	0.98	Fasn (encoding fatty acid synthase), Acaca, Gpat, Gpd1, and Scd2 (Fig. 5E).
28481866	0.98	Fasn, Scd1, Scd2 and Srebf1) was increased compared with the control liver (Figure 7).
29051053	0.98	fatty acid synthase (FASN), insulin-induced gene 1 (INSIG1), mitochondrial citrate transporter (SLC25A1), and stearoyl-CoA desaturase 2 (SCD2) in SCAP KO mice, the proportion of de novo synthesized FAs in the milk decreased by 25%, suggesting that SREBP-dependent pathway is necessary for optimal lipogenesis in the lactating mammary gland.
29921805	0.98	Scd2, Dgat1, Dgat2 and Fasn) was correlated with the development of 3T3-L1 pre-adipocytes into mature adipocytes.
30929409	0.98	fatty acid synthase (Fasn) and stearoyl-CoA desaturases (Scd1, Scd2) and transcription factors such as C/eba, Klf5, Srebf1, and Stat3 that are implicated in fatty acid and phospholipid synthesis.
29385670	0.97	Fasn, Scd1, and Scd2 regulating fatty acid synthesis was significantly increased, in contrast, fatty acid oxidation genes in mitochondria and peroxisome were clearly downregulated in KO mice.
	0.94	Fasn and Scd2 expression as opposed to reduction of the enzymes regulating fatty acid catabolism.
20463879	0.97	fatty acid synthase (Fasn), ATP citrate lyase (Acly), stearoyl-Coenzyme A desaturase 2 (Scd2), lanosterol synthase (Lss), farnesyl diphosphate synthetase (Fdps), and phospholipase A2, group V (Pla2g5).
24131481	0.97	fatty acid synthase (Fasn, FC = 1.81), Scd2 (FC = 2.15), and Elovl6 (FC = 3.21) (Figure 1A).
25849048	0.97	FASN, SCD2, AGPAT3), metabolism (e.g. LPIN2, LPPR4, CPT1A, SMPD3), and cholesterol homeostasis (e.g. SREBF2, SCAP) and transport (e.g. LPR1, SORL1, ABCA3, LRP8).
24818992	0.96	SCD2, ACLY and FASN downregulation.
	0.95	SCD2, ACLY and FASN were all downregulated by the addition of HFD.
	0.90	SCD-2, FASN and ACLY were significantly increased in the PTENf/f group.
31998465	0.96	SCD2, SCD3, SCD4, FASN, FADS1, ELOVL6, TECR, and ACSL5) and steroid biosynthesis pathway (CYP51, MSMO1, DHCR7, DHCR24, LSS, NSDHL).
28350851	0.95	fatty acid synthase (Fasn), uncoupling protein-1 (Ucp1), PR-domain zinc finger protein 16 (Prdm16), stearoyl-CoA desaturase 2 (Scd2).
	0.95	fatty acid synthase (Fasn), uncoupling protein-1 (Ucp1), PR-domain zinc finger protein 16 (Prdm16), stearoyl-CoA desaturase 2 (Scd2).
	0.86	Fasn, Ucp1, and Prdm16 while antibiotics plus ethanol further reduced Scd2 compared to antibiotics plus pair-fed.
31514294	0.94	SCD-2, and FAS were significantly decreased in the HFD + 0.6% PPF group compared to the HFD control group (all p < 0.001, Figure 5), while there was no difference in the mRNA level of SREBP-1c between the two groups.
27689005	0.93	Scd2 was increased, with similar trends for upregulation of Fasn, Fads3, and Fabp5 (Figure S3B).
21442273	0.80	FAS mRNA was reduced; SCD1 (ste-aroyl-coenzyme A desaturase) and SCD2 mRNA did not significantly differ.