Publication for Pitx3 and Foxe3

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
mmu	Pitx3	paired-like homeodomain transcription factor 3	18742			[link]
mmu	Foxe3	forkhead box E3	30923

Pubmed ID	Priority	Text
19334279	0.98	ak embryos show an altered spatial distribution of Foxe3 transcripts within the ak lens.
	0.98	Foxe3 in the anterior compartment indicates that Pitx3 activity is necessary for the maintenance of Foxe3 expression in the anterior lens epithelium.
	0.98	Foxe3 expression in the ak mutant by E12.5 (Fig. 2C,D) suggests that Pitx3 is necessary for the maintenance of the Foxe3 expression.
	0.98	Foxe3 expression in the ak mutant is not maintained past E12.5, suggesting that Pitx3 is directly or indirectly required for the maintenance of Foxe3 transcription.
	0.97	Pitx3 is expressed only in a small portion of the lens placode, while Foxe3 is expressed in the entire lens placode (Fig. 1C, D).
	0.97	Foxe3 and Pitx3 are expressed in the entire lens pit (Fig. 1E,F).
	0.97	Foxe3 in the posterior of the ak lens indicates that the primary lens fiber cells in the ak embryo do not undergo proper differentiation.
	0.97	Pitx3 expression is relatively unaffected in the Foxe3 null embryos (Fig. 2E-H), suggesting that Foxe3 does not have an important role in the regulation of Pitx3 transcription during early lens development.
	0.97	Pitx3 and Foxe3 in wild type, ak and Foxe3 mutants showed that Foxe3 is activated in the lens placode before Pitx3 and therefore Pitx3 is unlikely to have a role in the activation of Foxe3.
	0.97	Foxe3 was shown to play an role in the proliferation of the anterior epithelium, it is possible that the decreased proliferation of anterior lens cells in the ak mutant is due to the reduced activity of Foxe3.
	0.96	Foxe3 expression are found in the anterior of the lens (Fig. 2A), which develops into the lens epithelium, in the ak lens most of the Foxe3 transcripts are found in the posterior of the lens (Fig. 2B).
	0.96	Foxe3 mutants, we investigated whether these two transcription factors cooperate in the regulation of proliferation and whether the reduced proliferation in the ak lens can be explained by the abnormal expression of Foxe3.
	0.96	Foxe3 probe to an E12.5 ak embryo showing dramatically reduced expression of this gene in the lens.
	0.94	Pitx3 and Foxe3 were investigated, as these two transcription factors are expressed at the same time in lens development and their absence has similar consequences for lens development.
	0.94	Foxe3 expression precedes Pitx3 during the formation of the lens placode, but at later stages their expression appears to be identical.
	0.94	Foxe3 and Pitx3 revealed that in Foxe3+/-;+/ak double heterozygous embryos (Fig. 3E), the morphology of the lens is similar to the lens in ak heterozygous animals (Fig. 3C).
	0.94	ak lens the Foxe3 is no longer expressed in the anterior lens cells.
	0.93	Foxe3 and Pitx3 during lens development.
	0.93	Foxe3-deficient embryos, the proliferation of the lens epithelium is less affected than in the ak mutants, which have at least some Foxe3 activity.
	0.88	Foxe3 and Pitx3 during early lens development, we analyzed expression of these two genes by whole mount in situ hybridization.
	0.86	Pitx3 probe to an E13.5 Foxe3-deficient embryo showing only slightly reduced levels of expression of this gene in the lens.
	0.83	Pitx3 and Foxe3 is similar during early lens development, and since mouse embryos with mutations in these two genes display similar lens phenotypes, we investigated the expression of Pitx3 and Foxe3 in more detail.
	0.83	Foxe3 and Pitx3 expression is similar in the developing lens, we evaluated whether the expression of these two genes depends on each other.
	0.80	aphakia mutant are similar to the lens development in Foxe3 null mice.
	0.79	Foxe3 expression cannot account entirely for the lack of proliferation in ak lenses.
	0.78	ak/ak animals are typically club-shaped and smaller than lenses in Foxe3-deficient animals.
	0.77	Foxe3 and Pitx3 in wild type and ak embryos
	0.75	ak embryo hybridized with a Foxe3 probe showing expression of this gene in the abnormal lens.
29314435	0.98	FOXE3 is reduced in the Pitx3 null mouse lenses in agreement with other Pitx3 mouse mutant models, PROX1 expression does not appear to be reduced as in ak lenses, but rather is up-regulated in the lens anterior epithelium, suggesting that PITX3 functions to repress PROX1 in these cells.
	0.97	FOXE3 are associated with distinct ocular phenotypes, commonly involving microphthalmia, aphakia, and glaucoma, and predominantly affecting the anterior segment tissues, the lens and cornea.
	0.96	FOXE3, HSF4, MAF, and PITX3 cause congenital lens defects including cataracts that may be accompanied by defects in other components of the eye or in non-ocular tissues.
	0.96	Pitx3 and Foxe3, other findings suggest that PITX3 transcriptionally controls Foxe3 expression.
	0.91	Foxe3, Hsf4, Maf and Pitx3 in development and organogenesis.
	0.89	FOXE3, HSF4, MAF and PITX3.
	0.87	FOXE3, HSF4, MAF and PITX3 that are commonly associated with ocular defects, including cataract, in addition to other developmental defects.
	0.77	FOXE3 mutation c.720C>A (p.Cys240X) - located downstream of the forkhead domain reported in ten unrelated individuals to occur in the homozygous state - is frequently associated with aphakia and microphthalmia, among other eye defects.
	0.77	FOXE3 may be regulated by PITX3, which itself may be downstream of MAF.
	0.69	FOXE3 (MIM# 601094), HSF4 (MIM# 602438), MAF (MIM# 177075), PITX3 (MIM# 602669), mutations in which lead to ocular defects with a subset of shared features, but commonly exhibiting defects in the lens, including cataract.
	0.58	FOXE3, HSF4, MAF and PITX3 Causing Cataracts and Other Developmental Ocular Defects
25347445	0.98	Foxe3, which have roles in normal lens development, are altered by the Pitx3ak mutation.
	0.98	PITX3 protein may be essential for the normal expression of downstream genes such as Mip, Prox1 and Foxe3.
	0.97	Foxe3 enhancer and Mip promoter containing bicoid elements, which can interact with PITX3 protein.
	0.97	PITX3 protein to the Foxe3 enhancer and Mip promoter may lead to down-regulation of FOXE3 and MIP in miak mutants.
	0.96	Foxe3, Prox1, and Mip was altered because of the Pitx3 mutation, with large reductions in the lens vesicles in the mutants.
	0.96	Foxe3 and Mip oligo probes, including bicoid elements, when assaying PITX3 binding EMSAs (Figure 8).
	0.93	PITX3 resulting from the miak mutation was included in the DNA-protein complex, this result suggests that the truncated PITX3 proteins can bind the bicoid elements of Foxe3 and Mip.
20105280	0.98	FoxE3, Prox1 and Pitx3 are transcription factors that are critical for lens specification (Pax6), lens vesicle detachment (FoxE3, Pitx3) and cell cycle exit of lens epithelial cells (Prox1).
	0.97	FoxE3 and Pitx3.
	0.96	FoxE3 (Fig. 5F), Pitx3 (Fig. 5L) and alpha-crystallin (Fig. 5N).
	0.94	FoxE3 or Pitx3 expression as FoxE3 and Pitx3 mutants show persistence of a lens stalk.
	0.85	Foxe3 and Pitx3 were unaltered in Ras transgenic lenses.
	0.80	FoxE3 (Fig. 5F) and Pitx3 (Fig. 5L) in the transgenic lens epithelial cells was similar to nontransgenic lenses (Fig. 5A, E, K).
30991053	0.98	PITX3 and FOXE3.
	0.96	PITX3, FOXE3 staining all indicate that from E11.5-E13.5 there are still epithelial cells that undergo proliferation (KI67).
	0.92	PITX3 and FOXE3 in the Aey69 mutant lens.
24038357	0.98	Pitx3, Foxe3 and Zeb2.
	0.98	Foxe3, Otx1, Pitx3, Prox1, Six3, Sox2 and Zeb2, supports the idea that depletion of CBP and p300 disrupts the 'core' Pax6-dependent genetic machinery of lens cell fate determination and differentiation (Six3 Pax6 Sox2).
24503550	0.98	Pitx3 has been shown to play a role in the cell cycle of lens epithelial cells and fiber cell differentiation by positively regulating Foxe3 expression and negatively regulating Prox1 in the anterior lens epithelium.
	0.95	Foxe3 (Figure 8D) or Pitx3.
25406393	0.98	Foxe3 by Pitx3 and multiple direct targets of Hsf4 in the lens, such as DNase IIbeta and FGFRs.
	0.93	FOXE3, HSF4, MAF, PAX6 and PITX3) and structural (e.g. crystallins, connexins, MIP, BFSP2, EPHA2, EPHA5 and LIM2) proteins (see).
19389370	0.98	Foxe3, Pitx3, AP2alpha, and Maf are critically required for lens formation, and constitute a partial lens regulatory gene network (reviewed in).
20836031	0.98	Pitx3 is required for ALE maintenance, and functions by regulating Foxe3, Prox1, p27Kip1, p57Kip2 and Pdgfralpha.
24076321	0.98	FoxE3, c-Maf, Sox1, Sox2, Pitx3, and Prox1 necessary for lens morphogenesis.
26046913	0.98	Pitx3 mutant lens, expression of Foxe3, as well as Prox1, Mip and four crystalline genes was downregulated.
29337142	0.98	Foxe3, Pitx3 and Mafg exhibit high expression in early (embryonic) lens development stages compared to late (postnatal) stages.
30078984	0.98	Foxe3 in the lens epithelia of developing and adult mice, researchers found that chamber angle defects associated with mutations in mouse Foxe3 might result from changes in Pitx3, a gene in the same regulatory pathway as Foxe3.
29660784	0.97	PITX3, FOXC1, FOXE3, PAX6, LMX1B, GPR48, TFAP2A and TFAP2B.
	0.97	Pitx3 show that this gene is expressed in wild-type mice at E9.5 in the lens placode, similar to the expression pattern of Foxe3 in the lens, although the two genes do not interact to affect lens development.
19681134	0.97	Pitx3, Foxe3, Tcfap2a, and Sox2) known to direct lens development were not significantly affected (either directly or indirectly) before lens dystrophy.
21698120	0.97	Foxe3 and Prox1 as well as the cell cycle regulator p57KIP2 were found to be affected in Pitx3-deficient animals, which seems more likely to be related to the overall abnormal lens development in aphakia mice rather than direct involvement of Pitx3 in transcriptional regulation of these genes.
26330747	0.97	Foxe3, Pitx3, and Prox1 (Figure 5A), while Pitx3, Hsf4, Prox1, and Maf (c-Maf) are more abundant in lens fibers (Figure 5B).
24895407	0.96	PITX3, Foxe3 and Ap2alpha.
	0.93	PITX3, FOXE3 and AP2alpha.
17470285	0.96	Foxe3, Mab21like1, c-Maf, Pitx3, Sox1 and Hsf4) or retinal (e.g., Chx10, Mab21like2, Six6/Optx2, Vax1, Vax2) development.
21858719	0.95	FOXE3, PAX6, PITX3, MAF and VSX2 have been associated with ocular syndromes that include cataracts, microphthalmia, secondary glaucoma and anterior segment defects.
27687499	0.95	PITX3, FOXE3, PAX6, CYP1B1, and COL4A1 mutations are known causes of ASD, and these genes also participate in ocular morphogenesis in mice, but they do not account for all genetic forms of ASD.
30919050	0.94	PITX3 to Foxe3; in turn, FOXE3 could activate Prox1, and when expressed, its encoded transcription factor leads to an increased gamma-crystallin expression.
	0.93	Pitx3 and the Foxe3 mutations is the loss of crystallin expression and the downregulation of Prox1 (Anand and Lachke).
	0.86	PITX3 is Foxe3.
31053165	0.93	Foxe3, and Pitx3 are known to cause major lens defects.
	0.88	FoxE3, Gata3, Hsf4, Mab21l1, Msx2, Pitx3, Prox1, Sox1, Sox2, Sox11, Tfap2a (AP-2alpha), and Zeb2 (Sip1).
	0.62	Foxe3 enhancer is predicted here to possess two Pitx3-binding sites (Fig. 10), which is in agreement with earlier experimental studies.
30816539	0.93	FOXE3 is an additional target gene of PITX3 in mice and as it is conserved across mammalian species, direct PITX3 interaction with the consensus bicoid-binding site located upstream of FOXE3 gene may be additionally examined in humans.
21042563	0.92	FOXE3 (1q), PITX3 (10q) and VSX2 (14q), and the bZIP transcription factor V-MAF avian musculo-aponeurotic fibrosarcoma oncogene homolog (MAF, 16q) underlie cataract plus anterior segment developmental disorders and microphthalmia sometimes associated with secondary glaucoma.
	0.70	dysgenetic lens (Foxe3/dyl), aphakia (Pitx3/ak), eyeless (Pitx3/eyl), and ocular retardation (Vsx2/or-J).
18778700	0.88	FoxE3, Pitx3, Prox1 and Mab21l1 do not result in dominant inhibition of lens placode formation.
28237965	0.83	FOXE3, LMX1B, MAF, PAX6, PITX2 and PITX3 cause ASD.
26992779	0.64	Foxe3, Tfap2a (Ap2-alpha), Pitx3, Sox11, Prox1, Sox1, c-Maf, Mafg, Mafk, Hsf4, Fgfrs, Bmp7, and Tdrd7 in this tissue.