Publication for Nr1i2 and Nr1h4

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
mmu	Nr1i2	nuclear receptor subfamily 1, group I, member 2	18171			[link]
mmu	Nr1h4	nuclear receptor subfamily 1, group H, member 4	20186

Pubmed ID	Priority	Text
21801835	0.99	PXR itself is a transcriptional target of bile acid-activated FXR (Fig. 4).
	0.98	FXR, independently of PXR, demonstrating the complexity of in vivo regulation of these transporters.
	0.98	FXR and PXR are activated by bile acids and in turn regulate aspects of the enterohepatic cycling and metabolism of bile acids.
	0.98	FXR and PXR, either by administration of pharmacological ligands or genetic abrogation, have been shown to influence cholestatic liver injury in animal models to the point of significantly impacting on liver injury and survival after complete bile duct ligation or other models of bile acid accumulation, such as bile acid feeding.
	0.97	FXR and PXR, two members of the NR family whose activities are regulated by bile acids and which are implicated in the adaptive response to cholestasis.
	0.97	FXR, but activates PXR and the progesterone receptor.
	0.97	PXR and FXR, suggesting that induction by endobiotics differs from induction by xenobiotics.
	0.97	FXR agonists inhibit bile acid synthesis and promote bile acid excretion while PXR agonists promote bile acid detoxification, predominantly by the induction of CYP enzymes that mediate bile acid hydroxylation.
	0.96	PXR can be directly activated by certain bile acids or indirectly via transcriptional regulation by FXR.
	0.95	FXR and PXR, two members of the NR family whose activities are regulated by bile acids.
	0.92	FXR KO mice had a mortality and morbidity advantage, and were protected from developing hepatic bile infarcts, even with concurrent deletion of PXR.
	0.66	FXR and PXR: Potential therapeutic targets in cholestasis
23981290	0.98	PXR, LXR, FXR, and PPARalpha in regulating those RA/RXRalpha-dependent gene expression levels.
	0.98	FXR, LXR and PXR in the mouse liver.
	0.98	FXR, LXR, and PXR bound to almost 50% of RXRalpha-bound regions suggesting the extensive role of RXRalpha in regulating lipids.
	0.98	PXR, LXR, FXR, PPARalpha-bound genes were also bound by RXRalpha.
	0.97	pregnane x receptor (PXR), liver x receptor (LXR), farnesoid x receptor (FXR), and peroxisome proliferator-activated receptor alpha (PPARalpha) has been established.
	0.97	PXR, LXR, FXR, and PPARalpha have a great impact on various lipid processing pathways.
	0.97	FXR, and PXR have extensive roles in regulating lipids, they also have specific roles in regulating different types of lipids.
	0.97	PXR, LXR, FXR, and PPARalpha heterodimers.
	0.96	FXR (25%), LXR (12%), and PXR (8%).
	0.96	FXR (2019), RXRalpha/LXR (988), and RXRalpha/PXR (666), implying the relatively extensive role of these nuclear receptors in regulating hepatic gene expression.
	0.96	PXR, LXR, FXR, or PPARalpha) analyzed in the current study account for almost three quarters of RXRalpha binding genes in the liver.
	0.93	FXR), oxysterols (liver x receptor, LXR), xenobiotics (pregnane x receptor, PXR, and constitutive androstane receptor, CAR), vitamin D (vitamin D receptor, VDR), and RA (RAR).
	0.93	PXR/LXR/FXR/PPARalpha targeted homeostasis regulation of small molecules, which include monosaccharide and lipids.
	0.93	PXR, LXR, FXR, or PPARalpha.
	0.87	PXR, LXR, FXR, and PPARalpha in mouse livers
	0.86	PXR, LXR, FXR, and PPARalpha (Figure 1B).
	0.82	PXR, LXR, FXR, and PPARalpha
	0.80	PXR, and FXR.
	0.75	PXR, LXR, FXR, and PPARalpha binding sites overlapped with those of RXRalpha.
	0.65	FXR, 1,190 for LXR, and 868 for PXR in the mouse liver genome.
28043194	0.98	Fxr and Pxr regulate the transcription of metabolizing enzymes and transporters that dictate the absorption of nutrients and xenobiotics.
	0.98	Fxr and Pxr, respectively.
	0.98	FXR/Fxr) and pregnane X receptor (PXR/Pxr) regulate bile acid homeostasis, in addition to genes that are responsible for the metabolism and excretion of xenobiotics.
	0.98	Fxr and Pxr are reduced in late gestation, particularly on gestation days 14 and 17.
	0.98	Fxr and Pxr signaling during pregnancy, as evidenced by suppression of genes and proteins in both pathways.
	0.97	Fxr and Pxr signaling pathways are disrupted in response to high circulating concentrations of steroid hormones late in pregnancy leading to altered transporter expression.
	0.97	Fxr- and Pxr-mediated transcriptional regulation in the ileum of pregnant mice and points to the potential for different sex hormones to mediate transcriptional changes.
	0.96	Fxr and Pxr signaling pathways during pregnancy may have critical implications for bile acid and xenobiotic disposition.
	0.96	Fxr and Pxr during late pregnancy, and identify candidate sex hormones that may be responsible for altered nuclear receptor function.
	0.95	Fxr and Pxr during pregnancy.
	0.83	Fxr and Pxr during late pregnancy in mice and 2) identify potential sex hormones that mediate pregnancy-related changes in efflux transporters using an intestinal cell line.
	0.52	FXR cells were utilised to 1) recapitulate nuclear receptor enrichment typically observed in the ileum and 2) study the effects of candidate hormones on both FXR and PXR pathways in the same in vitro system.
18844851	0.98	bile acid receptor (FXR), and the xenobiotic receptors (PXR and CAR).
	0.98	FXR, PXR, and CAR all function as RXR heterodimers and are activated by dietary lipids.
	0.98	PXR, FXR, and VDR (Figure 2).
	0.97	FXR), xenobiotics (bind PXR, CAR), and a variety of cholesterol metabolites referred to as oxysterols (bind LXRs).
	0.97	bile acid receptor (FXR), and the xenobiotic receptors (PXR and CAR) function as sensors in the gut to protect the body from excess exposure to toxic dietary lipids.
	0.96	PXR, CAR, and FXR play a central role in xenobiotic and bile acid metabolism.
	0.94	PXR, CAR, and FXR, particularly with respect to drug interactions and first-pass metabolism; however, this system was not designed with our current pharmacopeia in mind, rather it likely evolved to protect the body from ingested toxins, toxins produced by pathogenic bacteria, or even endogenous compounds converted to toxins by commensal bacteria.
	0.85	PXR, CAR, FXR, and VDR regulate many of the same targets, there is also overlap in the chemical ligands by which they are activated.
	0.81	bile acid receptor (FXR), and the xenobiotic receptors (PXR and CAR).
23949303	0.98	Farnesoid x receptor (Fxr), Pregnane x receptor (Pxr), and Nuclear factor E2-related factor 2 (Nrf2) are transcription factors previously described to regulate transporter expression in liver.
	0.97	Fxr, Pxr, and Nrf2 target genes were regulated similarly in lean livers.
	0.97	Fxr, Hnf4alpha, Pxr pathways.
	0.97	Fxr and Nrf2 binding activity to known consensus sequences, with no observed change in Pxr binding activity, and increased Car pathway activity.
	0.96	Fxr, Nrf2 and Pxr expression.
	0.95	Fxr, Pxr, and.
	0.89	Pxr, or Fxr activity.
	0.87	Fxr, and Nrf2 binding, but did not affect Creb or Pxr binding.
	0.79	Fxr, Nrf2, and Pxr expression was equivocal between lean and OB mice, which is different from what was observed in intact livers from lean and OB mice of the same age.
23330546	0.98	FXR and PXR are highly expressed in tissues that are exposed to bile acids, including liver and intestine, whereas VDR is widely expressed in most tissues.
	0.98	Fxr-null mice were more susceptible to bile-acid- induced liver injury after BDL, despite induction of the PXR-regulated bile acid detoxification network.
	0.97	FXR and PXR knockout (KO) mice were administered CA, they were protected from bile acid toxicity and CAR target genes Ctp2b, Cyp3a, Mrp2, Ugt1a1, and Gsta were induced, suggesting that FXR, PXR, and CAR protect against hepatic bile acid toxicity in a complementary manner.
	0.96	FXR, PXR, and VDR).
	0.95	FXR, PXR, and VDR.
	0.94	FXR, PXR, CAR, and VDR are promising therapeutic targets for the treatment of liver and metabolic diseases.
	0.83	FXR, PXR, VDR, and CAR in regulation of drug and bile acid metabolism.
	0.82	FXR, PXR, VDR, and CAR target genes identified in bile acid metabolism are shown in Table 1.
27773686	0.98	FXR, constitutive androstane receptor (CAR), liver X receptor (LXR), and pregnane X receptor (PXR) also heterodimerize with the RXR and regulate transcription of genes involved in bile acid and lipid homeostasis, complicating interpretation of the results generated with FXR.
	0.96	PXR) that also heterodimerize with the RXR and coordinate with FXR to regulate subsets of downstream effectors and signaling pathways involved in energy and xenobiotic metabolism.
	0.95	FXR, CAR and LXRalpha, but partially increased the expression of the PXR-luc reporter gene.
	0.95	FXR antagonist activity of guggulsterones, avermectin-based drugs, and 1,3-indandione-based rodenticides as well their ability to alter signaling activity of other functionally relevant nuclear receptors, including CAR, LXRalpha, and PXR.
	0.86	FXR transactivation and showed no activity to CAR, LXRalpha, and PXR.
	0.80	FXR binding using a panel of 154 coregulator motifs and to induce or inhibit transactivation and coactivator recruitment activities of constitutive androstane receptor (CAR), liver X receptor alpha (LXRalpha), or pregnane X receptor (PXR).
	0.66	FXR but also CAR, LXRalpha, and PXR.
	0.56	FXR, CAR, LXRalpha, and PXR.
21829567	0.98	PXR), farnesoid x receptor (FXR) and liver x-receptor (LXR) are ligand-activated nuclear receptor that provide counter-regulatory signals to dysregulated immunity and modulates adipose tissue.
	0.98	PXR and FXR.
	0.98	PXR, FXR and LXR by lipid mediators, bile acids and oxysterols modulates lipid/cholesterol metabolism, provides counter-regulatory signals for macrophages and protection in rodent models of dysregulated innate immunity.
	0.98	PXR, and FXR.
	0.97	FXR was increased in the adipose tissue of colitic mice while LXR and PPARalpha were unchanged and PXR was downregulated (Figure 4, Panel 2; n = 5; #p<0.05 versus naive).
	0.95	PXR and FXR caused by TNBS.
28796169	0.98	PXR (pregnane X receptor), and FXR (farnesoid X receptor).
	0.98	FXR, PXR, and PPARs), and there is evidence that the bacterial metabolites generated in the lumen enter the colonic epithelial cells, many of them via selective transporters expressed in the apical membrane of these cells.
	0.97	PXR, FXR, and peroxisome proliferator-activated receptors (PPARs).
	0.95	pregnane X receptor (PXR), and farnesoid X receptor (FXR).
	0.95	PXR and FXR are also nuclear receptors and they are also activated by various xenobiotics.
	0.85	PXR, and FXR and Their Modulation by Bacterial Metabolites
30761355	0.98	FXR, LXR, PXR, PPARs, and LRH-1 are metabolic sensors in that they can be bound and activated by bile acids, and consequently regulate the levels and signaling intensity of the end-products through downstream effectors.
	0.98	PXR and CAR [ - ], although negative regulation of SULT2A1 by FXR has been reported in mice (Table 1).
	0.98	FXR, PXR, and CAR, as well as the bile acids that activate these receptors and/or Abcc2 directly (Table 1).
	0.97	FXR (section 3.3.1), PXR (section 3.3.3), CAR (section 3.3.4), and VDR.
	0.97	FXR and/or PXR (section 3.3).
23602448	0.98	farnesoid X receptor (FXR), pregnane X receptor (PXR) and vitamin D receptor (VDR) and one G-protein-coupled receptor (TGR5), identified bile acids as hormones that alter multiple metabolic pathways in many tissues.
	0.98	FXR, two other nuclear receptors, the pregnane X receptor (PXR; NR1I2) and the vitamin D receptor (VDR; NR1I1) are activated by specific bile acids.
	0.96	FXR and PXR (see below).
	0.85	FXR which is activated by a number of bile acids (CDCA>DCA>LCA>>CA; unresponsive to LCA), PXR is activated by the hepatotoxic bile acid LCA and 3-keto-LCA (EC50 10 muM) (Table 1) and is unresponsive to CDCA, DCA or CA.
27635169	0.98	PXR, CAR, and FXR, RA can exert its mitogenic effect in the liver.
	0.98	PXR, CAR, and FXR pathways, which could potentially mediate its mitogenic effect (illustrated in Figure 2).
	0.98	pregnane x receptor (PXR), constitutive androstane receptor (CAR), farnesoid x receptor (FXR) and their downstream pathways to regulate hepatocyte proliferation.
	0.81	PXR, and FXR causes hepatomegaly or liver cancer.
30396153	0.98	FXR, LXRalpha/beta, PXR, and THRalpha/beta.
	0.95	FXR, LXR, PXR, and THR require an activating ligand; and RXR is usually considered a passive partner.
	0.93	FXR, LXR, PPAR, PXR, and THR peaks, overlapping in different combinations (Figure 6C).
	0.90	FXR, LXR, PXR, and THR (arrows, 66 and 2.4 kb from the Mlxipl TSS).
19273238	0.98	pregnane X receptor (Pxr) activation on bile acid toxicity attenuation revealed a possible novel negative feedback loop for Fxr regulated genes.
	0.98	Pxr, which dimerizes with Rxr alpha, seemingly reduces Fxr levels ultimately down-regulating Ost alpha and Ost beta, but simultaneously inducing expression of Mrp3.
	0.95	FXR, RXR alpha, SHP, LRH-1, LXR alpha, HNF-4 alpha, and PXR, paints a complicated regulatory mechanism that needs further study.
20041971	0.98	FXR, a master gene that inhibits their uptake and synthesis, bile acids activate PXR, CAR and VDR.
	0.98	PXR, CAR and VDR, interact with FXR to modulate different pattern of genes involved in cell protection such as the phase I and II detoxification enzymes and canalicular and alternative basolateral bile acid transporters (reviewed in) (see table in Fig. 1).
	0.98	FXR, PXR and VDR (NR1I1) that play important roles in the regulation of bile acid synthesis and metabolism.
22876234	0.98	FXR, pregnane X receptor (PXR) and constitutive androstane receptor (CAR), have been shown to protect against the cytotoxic effects of bile acids by increasing expression of binding proteins, transporters, and enzymes that detoxify bile acids (Zollner et al.,; Schmidt and Mangelsdorf,).
	0.95	FXR and PXR or the membrane Galphas protein-coupled receptors TGR5 as well as Galphai protein-coupled receptors.
	0.93	FXR, LXR, or PXR, remains to be determined.
24801167	0.98	FXR and also other xenobiotic nuclear receptors, CAR and PXR.
	0.97	FXR), liver X receptor (LXR), pregnane X receptor (PXR), glucocorticoid receptor (GR), and others, regulate energy homeostasis, the formation and excretion of bile acids, and detoxification of xenobiotics.
	0.97	FXR), liver X receptor-alpha (LXRalpha), pregnane X receptor (PXR), glucocorticoid receptor (GR), and others.
30014852	0.98	FXR), the pregnane X receptor (PXR), the vitamin D receptor (VDR), the liver X receptor (LXR) and the G-protein-coupled receptor TGR5.
	0.96	FXR knockout (Nr1h4-/-) mice, Nr1i2-/- mice fed a high-fat diet exhibit increased fasting blood glucose levels and unchanged fasting insulin levels compared to wild-type mice.
	0.67	FXR and PXR may be involved in the differences noted between Bt KO- and Bt WT-colonized mice.
18789348	0.98	FXR), peroxisome proliferator-activated receptors (PPARs), and pregnane X receptor (PXR) are nuclear receptors which function as ligand activated transcription factors.
	0.92	FXR and PPARalpha and strongly activated PXR about 3.5-fold over background (Figs. 1A, B).
20949026	0.98	FXR ligand would results in the induction of PXR, that is a positive regulatory gene for CD36.
	0.88	PXR in the negative regulatory effects exerted by FXR agonists on this scavenger receptor, because FXR is a known PXR inducer.
21211565	0.98	FXR, PXR, CAR and vitamin D receptor.
	0.97	FXR, pregnane X receptor (PXR), and constitutive androstane receptor (CAR), is essential for the body to respond to endogenous or exogenous nutritional and environmental factors.
22579755	0.98	FXR and PXR double knockout mouse model, Guo et al. has demonstrated that FXR, PXR, and CAR function as transcriptional regulators of hepatic genes, including bile acid metabolizing genes, and, therefore, protect the liver against bile acid toxicity in a complementary manner.
	0.97	FXR, bile acids are also known to activate other lipid-sensing NRs, such as, PXR and CAR.
29352187	0.98	FXR, the PXR, the constitutive androstane receptor (CAR), and the VDR.
	0.98	FXR, PXR, CAR and VDR, it has been inferred that changes in secondary bile acids caused by dysbiosis have an influence on the host physiology, such as glucose, lipid, and drug metabolism, via these nuclear receptors.
30804707	0.98	FXR, and PXR, alleviates colitis by restraining NF-kappaB-mediated proinflammatory cytokines production and inhibiting inflammatory cytokine-induced IEC apoptosis and intestinal barrier damage (Figure 1).
	0.93	PXR, vitamin D receptor (VDR), farnesoid X receptor (FXR), and RAR-related orphan receptor gammat (RORgammat), in the pathogenesis of IBD and management strategies based on targeting these receptors.
21081494	0.98	FXR, pregnane X receptor (PXR), constitutive androstane receptor, and vitamin D receptor, have been shown to protect against the cytotoxic effects of bile acids by increasing expression of binding proteins, transporters, and enzymes that detoxify bile acids.
22467244	0.98	farnesoid X receptor (FXR/Fxr, encoded by the NR1H4/Nr1h4 gene), pregnane X receptor, vitamin D receptor, and a G-protein coupled receptor, TGR5, which is a critical mechanism for maintaining endobiotic and xenobiotic homeostasis.
23372731	0.98	pregnane-x-receptor (PXR), farnesoid-x-receptor (FXR) and retinoid-x-receptor (RXR) among others.
24007921	0.98	FXR, rather than the classic xenobiotic receptors Car (Constitutive Androstane receptor) and Pxr (Pregnane X receptor), had a major influence on the up-regulation of xenobiotic detoxification genes in Little mice.
24209497	0.98	Pregnane X Receptor (PXR), Farnesoid X Receptor (FXR), and Forkhead O1 are implicated in hepatic steatosis and in lipid and glucose metabolism .
25870546	0.98	FXR, bile acids such as LCA can activate the preganane X receptor (PXR) and vitamin D receptor (VDR) (Hylemon et al.,), both of which are expressed within the CNS (Eyles et al.,; Jain et al.,).
27639250	0.98	Fxr, Pxr, Pparalpha, Hnf4alpha, Lxralpha, Erralpha, and Rxr, along with numerous coregulators.
27709014	0.98	FXR in the intestine and liver, which induces the expression of PXR, facilitating the detoxification of lithocholate and xenobiotics by inducing CYP3A, phase-II enzymes (e.g., sulfotransferase 2A1), and transporters (e.g., MRP2 and MRP3) xenobiotics.
15312234	0.97	FXR, LXRalpha, PPARalpha, and PXR target gene expression.
	0.95	PXR, CAR, LXR or FXR to bind to one or more of these sites (reviewed in).
	0.91	FXR (farnesoid X receptor) and PPARalpha (peroxisome proliferator-activated receptor) RNA levels were stable, whereas CAR (constitutive androstane receptor) and PXR (pregnane X receptor) RNA levels were markedly suppressed and LXR (liver X receptor) RNA was elevated.
	0.79	FXR and PPARalpha were unchanged, whereas PXR and CAR RNA levels were reduced and LXRalpha RNA levels were increased (Fig. 2A).
	0.51	PXR and CAR RNA levels in mice have been reported by Beigneux et al, however our results do not support the reduction in RNA levels of RXRalpha, FXR and LXR and PPARalpha seen by others, perhaps due to differences in the experimental model, LPS dose or mouse strain.
21354151	0.97	PXR had a major effect on the expression of bile acid transporters, whereas FXR-/- mice showed profound dysregulation of phospholipid transporters.
	0.96	PXR has been reported to be a FXR target gene .
	0.93	PXR regulates the expression of SHP and Fgf15 remains to be determined, our results highly suggest a functional crosstalk between PXR and FXR.
	0.77	FXR-/- mice, but it was decreased in PXR-/- mice.
	0.74	PXR-/- mice, which was opposite to the increased bile acid synthesis in lithogenic diet-fed FXR-/- mice.
22524730	0.97	Pxr, constitutive androstane receptor (Car), nuclear factor E2-related factor 2 (Nrf2), Fxr, and Hepatocyte nuclear factor 1-alpha (Hnf-1alpha).
	0.94	farnesoid-X-receptor (Fxr) and pregnane-X-receptor (Pxr) mRNA expression was quantified in livers of db/db mice (Figure 7).
	0.93	Fxr, Pxr, Car and their target genes mRNA expression in livers of C57BKS and db/db mice.
	0.90	Fxr and Pxr in liver, suggesting that in the observed Slco decrease in Db/Db mice may be due to Ppar-alpha activation, and not Pxr and Fxr alterations.
23240054	0.97	FXR and PXR in the liver.
	0.97	FXR induces small heterodimer partner to inhibit Cyp7a1 expression and PXR also inhibits Cyp7a1 transcription.
	0.96	FXR deletion can also protect hepatocytes by facilitating the export of bile acids into blood and their renal excretion via compensatory mechanisms such as PXR activation.
	0.91	farnesoid X receptor (FXR; NR1H4) and PXR have been investigated in the rodent bile-duct ligation (BDL) model of cholestasis.
22291955	0.97	FXR and PXR, emphasize a plausible role as putative ligands for ancestral sponge nuclear receptor(s).
	0.97	FXR antagonist, further studies have shown that it functions as a ligand for multiple nuclear receptors, including PXR, the GR, the androgen and mineral corticoid and progesterone receptors.
	0.97	FXR, PXR, CAR , the liver receptor homologue-1 (LRH-1), SHP and the glucocorticoid receptor.
28793934	0.97	FXR), peroxisome proliferator activated receptor alpha (PPARalpha) and PXR as well as by the gut microbiota.
	0.95	FXR, PPARalpha and PXR by measuring through qPCR the transcription levels in the liver of some of their target genes.
30344015	0.97	Fxr, and Pxr KO mice in GF animals revealed that AHR-regulated genes showed an expression in GF mice similar to that observed in Ahr KO mice, whereas the opposite is observed in Pxr KO animals (Figures 6E and S6A).
	0.96	Fxr knockout (KO) mice revealed a feminization of gene expression (Figures 6A, 6B, and 6D), while Pxr KO mice partly showed a masculinization (Figures 6C and 6D).
19718444	0.97	FXR leads to elevation in hepatic bile acid levels that results in activation of CAR and PXR and damage to hepatocytes.
21335546	0.97	FXR, PXR, and CAR protect against hepatic bile acid toxicity in a complementary manner and nuclear receptors can be modulated by synthetic drugs and natural products.
28249279	0.97	FXR over other BA receptors including pregnane X receptor (PXR), constitutive androstane receptor (CAR), and vitamin D receptor (VDR).
29098111	0.97	FXR), the pregnane X receptor and the vitamin D receptor.
30319417	0.97	FXR, PXR, TGR5, VDR, and S1PR2.
30013008	0.96	PXR activation was involved in the different patterns of intrahepatic cholestasis models (i.e., FXR/SHP double KO vs. BSEP KO), suggesting the heterogeneity of intrahepatic cholestasis.
	0.94	FXR, pregnane X receptor (PXR), and CAR ligands regulate different target genes, it seems that a combination of ligands/activators of FXR, PXR, and/or CAR could reduce the potential side effects of FXR activation alone in severe cholestasis.
20091679	0.96	FXR bound to several sites within the first intron of the Nr1i2 gene, which encodes pregnane X receptor (PXR; highest peak value: 654 in liver and intestine, indicated by an asterisk; Fig. 4A).
22414897	0.96	FXR biology is that bile acids are also ligands for pregnane X receptor (PXR), constitutive androstane receptor (CAR; also known as NR1I3), vitamin D receptor (VDR) and the G protein-coupled receptor TGR5 (also known as GPBAR1).
29184608	0.96	PXR is the foremost physiologic and adaptive sensor of LCA especially considering that FXR another important bile acid sensor is unresponsive to LCA.
30620001	0.96	PXR in the induction of a range of drug metabolism genes22 and the direct activation of PXR by elevated BA levels.38 In accord with this, we previously found that combined CAR/PXR deletion in the DKO background (Fxr;Shp;Car;Pxr quadruple knockout) completely abolished CYP gene induction.10 This impairs bilirubin-conjugation processes and results in a dramatic accumulation of indirect bilirubin.
31646148	0.96	FXR mediating pro-depressive phenotype, and PXR, VDR and TGR5 mediating their antidepressant action.
21672564	0.95	FXR receptor and other nuclear receptors, for instance PXR and CAR receptors.
	0.93	FXR/NR1H4) is a member of the ligand-activated nuclear receptor superfamily, which also includes the pregnane X receptor (PXR/NR1I2), the constitutive androstane receptor (CAR/NR1I3), and the vitamin D receptor (VDR/NR1I1).
22609541	0.95	Fxr-null and Pxr-null mice were treated with GW4064, a significant induction of CYP3A11, the mouse equivalent of human CYP3A4, expression was observed in wild-type and Pxr-null mice, but not in Fxr-null mice.
	0.95	FXR is involved in bile acid-induced CYP3A expression, although the participation of other receptors such as PXR, constitutive androstane receptor (CAR; NR1I3) and vitamin D receptor (VDR; NR1I1), activated by bile acids, that also regulate CYP3A expression, cannot be excluded.
23926955	0.95	PXR, PPARalpha, and FXR.
	0.90	PXR and PXR-regulated Cyp3a11 and Cyp3a25, PPARalpha and PPARalpha-regulated Cyp4a10 and Cyp4a14, and FXR and FXR-regulated Cyp7a1 and Cyp27a1.
21593203	0.95	FXR, BA have been reported to activate the G protein-coupled BA receptor (TGR5), the pregnane X receptor (PXR), the vitamin D receptor (VDR), or the formyl peptide receptor (FPR).
28714273	0.95	Pregnane X receptor (PXR), a target of FXR that regulates Cyp3a11, is also higher in KO, while fibroblast growth factor receptor 4 (FGFR4), the receptor for FGF15-mediated regulation of BA homeostasis, is unchanged (Figure 3E).
26134028	0.93	Pregnane X Receptor (PXR) and Farnesoid X Receptor (FXR, NR1H4), play key roles in the control of energy homeostasis .Secondary bile acids are more potent ligands for TGR5 (affinity for TGR5: LCA>DCA>CDCA>CA) than for FXR (affinity for FXR: CDCA>DCA=LCA>CA) (for review, ).
27733832	0.91	PXR, PPARgamma, alpha, beta/delta, and LXRalpha, beta transactivities (data not shown), suggesting that the silybin activates FXR specifically.
26670557	0.88	PXR signalling, and that Gly-MCA is an intestine-specific FXR inhibitor circumventing the potential adverse outcomes that would result from liver FXR antagonism.
19273222	0.84	FXR as bile acid sensor, PXR and CAR as xenobiotic sensors involved in detoxification pathways, LXR and PPARgamma for their recently identified anti-inflammatory activities and the orphan receptors LRH-1, HNF4alpha and SHP, involved in the transcriptional regulation of various genes involved in bile formation and hepatobiliary transport.
27113289	0.84	PXR activation appeared to overlap with the aryl hydrocarbon receptor signaling, whereas CAR activation appeared to overlap with the farnesoid X receptor signaling, acute-phase response, and mitochondrial dysfunction.
25065623	0.78	FXR), dietary ligands and aryl hydrocarbon receptor (AhR), we focused on pregnane X receptor (PXR), since its promiscuous ligand binding pocket might well be capable of accomodating diverse small bacterial metabolites.
24878541	0.69	FXR belongs to a sub-cluster of metabolic nuclear receptors that also includes Vitamin D Receptor (VDR, NR1I1), Constitutive Androstane Receptor (CAR, NR1I3), Pregnane X Receptor (PXR, NR1I2) and Liver X Receptor alpha and beta (LXRalpha, NR1H3; LXRbeta, NR1H2).
30660825	0.69	FXR), PXR, and vitamin D receptor (VDR), as well as cell surface receptors, e.g., G-protein coupled bile acid receptor (GPBAR1 or TGR5), sphingosine 1 phosphate receptor 2 (S1PH2), and muscarinic receptors 2 and 3.