Publication for Hnf4a and Nr1i2

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
mmu	Hnf4a	hepatic nuclear factor 4, alpha	15378			[link]
mmu	Nr1i2	nuclear receptor subfamily 1, group I, member 2	18171

Pubmed ID	Priority	Text
22952394	0.99	HNF-4 also targets genes indirectly through the activation of the transcriptional regulators Hnf1a and PXR, which are crucial for expression of subsets of hepatocyte specific genes.
31993314	0.98	PXR, CAR, HNF4alpha, and PPARalpha are all key transcriptional regulators of DMEs, it is reasonable to assume that altered expression of these nuclear receptors is an underlying mechanism contributing to the changed expression of DMEs by an HFD.
	0.97	pregnane X receptor (Pxr), hepatocyte nuclear factor 4 alpha (Hnf4alpha), and peroxisome proliferator-activated receptor alpha (Pparalpha).
	0.97	Pxr was observed in all HFD groups as well as elevated expression of Pxr and Hnf4alpha in the HFD group for 4 weeks compared to the corresponding LFD groups (Fig. 2).
	0.94	Pxr, Hnf4alpha, and Pparalpha) were demonstrated in the HFD groups at days 30 and/or 60 compared to the age-related LFD groups, while the expressions of DMEs, including Cyp1a1, 1a2, 2e1, Ugt1a1, and Sult1a1, were also induced in these groups (Figure 4, Figure 5).
	0.89	PXR, CAR, and HNF4alpha, are also associated with the development of obesity.
	0.87	Pxr and Hnf4alpha in the liver of 30-day offspring was also induced by HFD (Fig. 4B and C).
16604179	0.98	HNF4alpha can directly regulate pregnane X receptor (PXR) expression during fetal liver development and thus regulate PXR responses to xenobiotics .
	0.97	HNF4alpha regulation of PXR is also a prime example of a cascade of nuclear receptor expression.
	0.97	HNF4alpha regulates PXR expression , SF1 controls DAX1 expression , Oct4 expression is sequentially regulated by SF1, GCNF and COUP-TF .
30396153	0.98	HNF4alpha and RXR heterodimeric partners PPARalpha, FXR, LXRalpha/beta, PXR, and THRalpha/beta.
	0.94	HNF4, RXR, FXR, LXR, PPAR, PXR, and THR peaks, overlapping in different combinations (Figure 6C).
	0.94	HNF4alpha constitutively mediate this LBD-driven process; PPAR, FXR, LXR, PXR, and THR require an activating ligand; and RXR is usually considered a passive partner.
22952895	0.98	PXR gene has been shown to possess an HNF4alpha and farnesoid X receptor (FXR) binding sites in the 5' UTR and in the intronic regions respectively that regulate its expression.
	0.98	HNF4alpha, can modulate the expression of PXR in hepatocytes through its binding site located in the minimal region of 100 bp upstream of +1 transcription start site.
27036855	0.98	pregnane X receptor (PXR) and hepatocyte nuclear factor 4 alpha (HNF4alpha).
	0.98	HNF4alpha, PPARalpha, CAR and PXR and their control through pulsatile GH signaling and the small heterodimeric partner (Shp), a nuclear factor that represses this regulation.
18611952	0.98	HNF4alpha, Foxa1, Foxa2, HNF6, C/EBPgamma, COUP-TFII, LRH1, USF1, PXR, FXRalpha and GATA6.
18660816	0.98	Pxr, and Car have been shown to play complementary roles in protecting the liver from bile acid toxicity and several other transcription factors (Hnf1alpha, Hnf1beta, and Hnf4alpha) have been established to play a central role on bile acid metabolism.
18778245	0.98	PXR, LXR (liver X receptor) and HNF4alpha (hepatocyte nuclear factor 4alpha).
19239393	0.98	HNF4alpha is a key regulator of PXR expression during fetal liver development and in-activation of HNF4alpha in mice suppressed CYP3A11 and PXR expression.
21498392	0.98	HNF4alpha as well as the major regulators of drug metabolism, PXR, CAR, and their dimerization partner RXRalpha.
21801835	0.98	PXR activators, such as the steroid PCN, significantly decreased CYP7A1 expression, with competition between PXR and PGC-1alpha for binding to HNF4alpha, thereby blocking PGC-1alpha-stimulated activation of CYP7A1 by HNF4alpha.
22808024	0.98	pregnane X receptor (PXR, Nr1i2), liver X receptor (LXR, Nr1h3), farnesoid X activated receptor (FXR, Nr1h4), aryl-hydrocarbon receptor (AhR), and hepatic nuclear factor 4, alpha (HNF4alpha) remained unchanged with graded Nrf2 activation.
23349477	0.98	PXR competes with HNF-4alpha for the binding to PGC-1alpha, suggesting yet another mechanism by which PXR might suppress hepatic gluconeogenesis.
23462932	0.98	HNF4alpha cooperatively enhances the transcriptional activity of constitutive androstane receptor (CAR) and pregnane X receptor (PXR) at the CYP3A4 promoter.
23894377	0.98	HNF4alpha target pathways were significantly down regulated by cold stress including constitutive androstane receptor (CAR; Nr1i3,80 fold)and pregnanexreceptor (PXR; NR1i2; 28 fold), both involved in the expression of drug metabolising enzymes and this was accompanied by a significant down regulation of Phase I (CYP2B, CYP2C, CYP3A) and Phase II genes (UDP-glucuronosyl-transferases UGT1A1, UGT1A9).
24953190	0.98	steroid and xenobiotic receptor (SXR), and hepatocyte nuclear factor 4alpha (HNF4alpha).
25209997	0.98	HNF4A in adults has little effect on the expression of other nuclear receptors such as FXR, PXR, and LXR that play important functions in liver, their expression is strongly diminished in the Taf4ahep-/- liver also contributing to the more severe phenotype.
26219821	0.98	HNF4alpha, GR, PXR, and CAR.
26924429	0.98	PXR acts as a co-repressor of FoxO1 and inhibits FoxO1-mediated transcription by preventing its binding to its response elements in target genes such as PEPCK1 and G-6-P. Further studies revealed that activation of PXR can also repress transcription of PEPCK1 and G-6-P by inhibiting hepatocyte nuclear factor 4alpha (HNF4alpha) and cAMP response element-binding protein (CREB) activity, respectively.
27639250	0.98	Pxr, Pparalpha, Hnf4alpha, Lxralpha, Erralpha, and Rxr, along with numerous coregulators.
30336042	0.98	PXR, LXR, FXR, PPAR and TH, as well as the interactions with insulin- or glucagon-responsive transcription factors such as HNF4alpha, C/EBPalpha, PGC-1, and FOXO1.
30555544	0.98	PXR, ER, LRH-1, and HNF4alpha) and negatively modulating their transcriptional activities.
19041682	0.97	HNF4alpha > CAR > PXR.
	0.95	HNF4alpha is not surprising because it directly controls the expression of CAR and the glucocorticoid receptor (GR), which controls the expression of PXR.
22457827	0.97	PXR, HNF4alpha, HNF4gamma, FXRalpha, PPARalpha display a specific expression in PCT and PST (Figure 4A-F, results for AR and ERalpha were published earlier).
23949303	0.97	Hnf4alpha, Pxr pathways.
27709004	0.97	pregnane X receptor (PXR), constitutive androstane receptor (CAR), farnesoid X receptor (FXR), hepatocyte nuclear factor 4 alpha (HNF4alpha), and estrogen receptor (ER), have been demonstrated to play important roles in the regulation of gene expression of drug-metabolizing enzymes and transporters.
21376070	0.95	PXR-null and hPXR mice (Fig. 5C-5D; hPXR data is not shown) indicates that mouse PXR is important for the normal physiology of the liver, such as the constitutively regulating the expression of some CYPs (Table 1,2) There have been other studies that have observed hepatocyte hypertrophy in knockout mouse models, including those that lack peroxisomes and HNF4alpha-null mice.
19273238	0.94	HNF-4 alpha, and PXR, paints a complicated regulatory mechanism that needs further study.
27531557	0.94	HNF4alpha and of the nuclear hormone receptor Pxr were not significantly different between wild-type and mutant livers (Figure 2) indicating that there was not a general disruption of transcriptional regulation in the Albumin-cre; Lats1/2 livers.
21920422	0.92	pregnane X receptor (PXR); hepatocyte nuclear factor 4alpha (HNF4alpha) is thought to be important for Cyp3a25 and Cyp2d22 regulation; constitutive androstane receptor (CAR) plays a critical role in modulating Cyp2b10; HNF1alpha may affect Cyp2e1 expression; and Cyp4a14 induction is mediated by peroxisome proliferator-activated receptor alpha (PPARalpha).
30102401	0.90	hepatocyte nuclear factor 4 alpha (Hnf4a), retinoic acid recetor beta ( Rarb), retinoid X receptor beta ( Rxrb), PXR (Nr1i2), peroxisome proliferator activated receptor delta (Ppard), estrogen receptor alpha (Esr1), COUP transcription factor 2 (Nr2f2), small heterodimer partner (Nr0b2; Shp1), as well as aryl hydrocarbon receptor (Ahr;AHR), and CAR (Nr1i3) itself.
28350814	0.58	HNF4alpha regulates CAR expression with HNF4alpha > CAR > PXR regulation of constitutive Cyp expression.
19273222	0.56	PXR and CAR as xenobiotic sensors involved in detoxification pathways, LXR and PPARgamma for their recently identified anti-inflammatory activities and the orphan receptors LRH-1, HNF4alpha and SHP, involved in the transcriptional regulation of various genes involved in bile formation and hepatobiliary transport.