Publication for Nr1i2 and Ces2a

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
mmu	Nr1i2	nuclear receptor subfamily 1, group I, member 2	18171			[link]
mmu	Ces2a	carboxylesterase 2A	102022

Pubmed ID	Priority	Text
20163318	0.98	Ces6 gene represents a likely PXR-target gene in mouse liver and small intestine.
	0.98	PXR knockout mouse model, we reveal that induction of Ces6 messenger RNA and protein by pregnenalone 16alpha-carbonitrile (PCN), a well known rodent PXR activator, is PXR-dependent in both mouse liver and intestine.
	0.98	PXR-binding to three enhancer elements located in the upstream region of the mouse Ces6 gene under physiological conditions (figure 1, top panel), which are approximately 84bp (site 1), 1796bp (site 2), and 2340bp (site 3) upstream of the transcription start site of Ces6.
30060524	0.98	PXR target genes:such as carboxy esterase 2a (Ces2a), cytochrome P-450 3a11 (Cyp3a11), glutathione S-transferase pi 1 (Gstp1), and multi drug resistance 1 (Mdr1):were markedly upregulated by the treatment with Rif (Figure 2A) in hPXR mice.
	0.94	Ces2a, Cyp3a11, Gstp1, and Mdr1 are well-known PXR target genes.
20727377	0.98	PXR knockout (-/-) mice, PXR was linked to the transcriptional regulation of CESs, where Ces6, a member of the CES2 subtype, was induced after treatment with pregnenolone 16alpha-carbonitrile (PCN), the known selective activator of mouse (m) PXR, in wild type but not in PXR-/- mice.
26179144	0.97	Ces2a mRNA expression was induced in liver and intestine following treatment with the PXR and CAR agonists pregnenolone-16a-carbonitrile (PCN) and 1,4-bis-[2-(3,5-dichloropyridyloxy)] benzene (TCPOBOP), respectively.
	0.95	PXR ligand-binding domain was knocked-in to the murine PXR reported induction of Ces2a, suggesting potential relevance to humans.
24486573	0.96	PXR target genes CYP3A11 (O) and CES2A (P).
	0.96	CES2A, both PXR target genes.
	0.94	PXR target genes CYP3A11 and CES2A.
27113289	0.93	Ces2a contributes more to the Ces-mediated hydrolysis following a xenobiotic insult that activates PXR or CAR.
25018661	0.92	Ces6 was recently shown to be regulated in vivo by the pregnane X receptor (PXR) and constitutive androstane receptor (CAR), two members of the nuclear receptor superfamily, when mice were treated with prototypical murine PXR- and CAR-specific ligands, pregnenolone 16alpha-carbonitrile and 1,4-bis[2-(3,5-dichloro-pyridyloxy)]benzene, respectively.) Although it was previously shown that pyrethroids can activate human PXR and CAR, it is not apparent that pyrethroids have any effect on the levels of CES1 and CES2 mRNA in human primary hepatocytes following insecticide treatment.) However, PXR-responsive CYP3A4 mRNA was found to be significantly induced in the pyrethroid-treated hepatocytes.
	0.68	CES (Ces6) does appear to be inducible in a PXR-dependent manner both in vitro and in vivo.)