Publication for Nf1 and Spred1

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
mmu	Nf1	neurofibromin 1	18015			[link]
mmu	Spred1	sprouty protein with EVH-1 domain 1, related sequence	114715

Pubmed ID	Priority	Text
23443682	0.98	SPRED1) recruits NF1 to membranes and is required for NF1 to inactivate Ras in cell lines.
	0.98	SPRED1 engages NF1 and an N-terminal Sprouty (SPR) domain allows membrane localization of the SPRED1-NF1 complex, most likely through interaction with phospholipids and caveolin 1 (Fig. 2B).
	0.98	NF1 to membranes and, therefore, its targeting to Ras is mediated by SPRED1 in some cell types.
	0.98	NF1 binds membranes in these cell types through recognition of SPRED2 or SPRED3, proteins that are homologous to SPRED1.
	0.98	NF1 to membranes in the absence of SPRED1.
	0.98	NF1 can be targeted to membranes through an undefi ned interaction with the SPRED1 protein that binds to membrane lipids through its SPR domain.
	0.95	SPRED1 mutations are nonsense mutations that lack the SPR domain, which results in the loss of membrane localization of NF1 in cultured cells.
	0.87	NF1 protein region is recognized by the EVH domain and whether or not the SEC14-PH domain of NF1 cooperates with SPRED1 in membrane targeting is not known.
19186160	0.98	NF1 or SPRED1 result in elevation of ERK pathway activation.
	0.96	SPRED1 gene product normally acts to suppress ERK activation, as does NF1.
	0.76	NF1-like syndrome, which results from loss-of-function mutations in the SPRED1 gene.
24183794	0.98	SPRED-1 targets the neurofibromin-1 (NF1) RasGAP to membranes, thereby allowing NF1 to inactivate Ras.
	0.96	NF1, and that loss of membrane targeting of these other RasGAPs underlies the increased MAPK activation in SPRED1/2 deficient LEC, although this remains to be determined.
23312374	0.97	Nf1+/- mice, defective spred1 function in mice resulted in increased MAPK signaling, in addition to deficits in learning and memory.
29301958	0.97	Nf1, Dusp6, Spred1, Rasa2, and SPOP (Fig. 1D).
29079424	0.96	neurofibromin suggests that these isoforms may compensate for loss of Spred1 and thus helps explain the milder phenotype associated with NFLS in comparison with NF1.
	0.95	NF1 are explained by the shared underlying molecular mechanism: SPRED1 downregulates the RAS/MAPK pathway through neurofibromin, the NF1 gene product.
	0.85	SPRED1 cause Neurofibromatosis Legius syndrome (NFLS), a mild form of Neurofibromatosis 1 (NF1), which is characterized by multiple cafe-au-lait skin spots, variable dysmorphic features such as hypertelorism or macrocephaly, lipomas, and mild learning disabilities or attention problems (Figure 5A).
20345245	0.93	Nf1, lossof- function mutations of SPRED1 also result in hyperactivity in MEK/MAPK signaling.
	0.53	Spred1 mutations involves some of the same symptom dimensions (other than neurofibromas) seen in NF1.
28455524	0.91	Nf1 , Ptpn11 , Spred1 mice and conditional Kras G12V mice.
	0.90	NF1, SPRED1, PTPN11 and KRAS which diverge in their relative subcellular signaling mechanisms.
22821737	0.79	Spred1 knockout mice revealed hippocampal synaptic plasticity and learning deficits similar to those previously described in Nf1+/- heterozygous mice.
25393061	0.77	Nf1 and Spred1 mouse models, inhibitor treatment may also be beneficial for learning issues in an animal model for NS.
21495177	0.61	Spred1-/- mice is remarkably similar to that in Nf1+/- mice.