Publication for Fbn1 and Loxl1

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
mmu	Fbn1	fibrillin 1	14118			[link]
mmu	Loxl1	lysyl oxidase-like 1	16949

Pubmed ID	Priority	Text
27045031	0.98	fibrillin-1 and Loxl1, all vital components for elastic fiber assembly, are down-regulated in PpargC/- aorta.
	0.92	fibrillin-1 cause significant fragmentation and disorganization of elastic fibers, whereas Loxl1 deficiency leads to imprecise and lower cross-linking of elastic fibers.
	0.79	fibrillin-1 (0.84) and lysyl oxidase homolog 1 (Loxl1; 0.87) were decreased, whereas the levels of collagen alpha-1(I) (1.00), alpha-2(I) (1.09), and tubulin alpha-1A (1.00) were not altered in PpargC/- aorta.
26151842	0.98	Fbn1, Fstl1, Gja1, Hmmr, Igf1, Loxl1, Lpar4, Mtac2d1, Nid1, Pof1b, Ptpla, Tmem45a, Wdt2 (Figure 4B).
	0.94	Fbn1, Col1a1, Adamts12, Igf1, Fstl1, Loxl1, and Col5a1.
20236620	0.98	fibrillin-1 facilitates correct deposition of Lox-tropoelastin and Loxl1-tropoelastin onto microfibrils, ensuring a proper ratio between fibulins and Lox proteins to allow for maximal cross-linking of tropoelastin.
30467144	0.98	Fbn1, Has1 and Loxl1) that promote rapid ECM deposition.
30227601	0.96	fibrillin-1, lysyl oxidase-like protein-1 (LOXL-1), extracellular superoxide dismutase, latent TGF-beta binding protein (LTBP)-2, and LTBP-4.
19321153	0.95	fibrillin-1 and LOXL-1, thus placing it in a distinct position to facilitate interactions between these molecules.
23168383	0.91	fibrillin-1, microfibrillar-associated protein 2 (Mfap2), microfibrillar-associated protein 5 (Mfap5), and lysyl oxidase homolog 1 were more abundant whereas collagen III and arginase-1 were less, as compared to the liver ECM.
27386756	0.86	LOXL1, PALLD, POSTN, PRRX1, PRRX2, PRSS23, PTX3, TGFB3, TGFB1I1 and THBS1, which have also been shown to be coexpressed with mouse Fbn1 .
31935848	0.78	Fbn1, Fbn2, Sfrp1, Tnfrsf11b, Hapln1, Igf1, and Rspo2, among others), extracellular matrix organization (Dmp1, Mmp12, Mmp19, Adamts2, Tnc, and Loxl1, among others), inflammatory response (Cxcl10, C3ar1, C4b, Ccr5, Ccl8, and Il33, among others), and Wnt signaling (Fzd1, Nfatc4, Wnt16, Sfrp1, Sfrp4, Nkd2, Prickle2, Rspo2, Rspo1, and Dkk3, among others) (Figure 3B, Table S2).
22058072	0.75	fibrillin-1, and lysyl oxidase-like 1 also result in offspring that exhibit abnormal lung development, which in some cases results in pulmonary pathology resembling emphysema in mice surviving beyond the perinatal period.
30389913	0.75	Fibrillin-1/Fbn1, Fibrillin-2/Fbn2, Fibulin-4/Fbln4, Fibulin-5/Fbln5, Lox, and Loxl1 was not significantly changed in E18.5 Myh10-/- lungs compared with wild-type lungs (Supplementary Fig. 5d).